Immunodeficient Mouse & Rat Strain Portfolio
Our immunodeficient mouse model portfolio is based on the proprietary state-of-the-art BRGS mouse model.
Compared to traditional immunodeficient strains, such as NOD-SCID and NSG, the BRGSF mouse represents the most immunodeficient model generated to date, with defect of both the murine lymphoid and myeloid compartments, and thus represents a strongly adapted animal model for xenograft of human tumor and/or immune system.
The portfolio consists of the following strains:
- BRGS (BALB/c Rag2tm1Fwa Il2rgtm1Cgn SirpaNOD)
- BRGSF (BALB/c Rag2tm1Fwa Il2rgtm1Cgn SirpaNOD Flt3tm1lrl)
- BRGSF-A2 (genetically humanized for HLA-A2HHD–Tg(HLA-A/H2-D/B2M)1Bpe)
Compared to the traditional immunodeficient nude rats, which lack T cells but maintain a normal repertoire of all other immune cells, including B and NK cells, the SDRG model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1-/- Il2rγ-/-), resulting in a B, T and NK cell deficiency.