Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.

‍

Applications

Our immunodeficient models are valuable tools in a wide range of biomedical fields, including oncology, immunology and infectious diseases. Their compromised immune systems allow the engraftment of human tissues, cells (such as human hematopoietic cells) or tumors, making them ideal models for evaluating human immune responses, disease progression and therapeutic interventions. The genetic modifications in our immunodeficient models are designed to reduce the number of murine immune cells while making them more robust and predictable than SCID models.

General model features

Absence of lymphoid cells
Extended lifespan, enabling long-term studies
Robust models with high tolerance to tumor engraftment

Elovl6

|

Elongation of very long chain fatty acids protein 6

Synonyms:

—

Gene ID (NCBI):

170439

Protein function:

Elongates saturated and monounsaturated fatty acids in lipid biosynthesis

Applications:

Used in metabolic disease and lipid metabolism research

Slc17a6

|

Solute carrier family 17 member 6

Synonyms:

VGLUT2

Gene ID (NCBI):

140919

Protein function:

Loads glutamate into synaptic vesicles for excitatory neurotransmission

Applications:

Studied in neurotransmission and glutamate signaling

Lnx2

|

Ligand of numb-protein X 2

Synonyms:

PDZRN2

Gene ID (NCBI):

140887

Protein function:

Acts as a scaffold and E3 ligase; regulates Notch signaling and neurogenesis

Applications:

Studied in ubiquitin signaling and neural development

Elmo1

|

Engulfment and cell motility 1

Synonyms:

Ced-12

Gene ID (NCBI):

140580

Protein function:

Regulates Rac1 activation for phagocytosis and cell migration

Applications:

Studied in phagocytosis, inflammation, and Rac signaling

Plxnb2

|

Plexin B2

Synonyms:

—

Gene ID (NCBI):

140570

Protein function:

Receptor for semaphorins; regulates axon guidance, cell migration, and immune signaling

Applications:

Studied in neurodevelopment, immunity, and cancer

Rxfp2

|

Relaxin/insulin-like family peptide receptor 2

Synonyms:

Lgr8, GREAT

Gene ID (NCBI):

140498

Protein function:

GPCR mediating effects of insulin-like peptide 3 (INSL3); key in testis descent

Applications:

Used in reproductive and endocrine studies

Kcnn3

|

Potassium calcium-activated channel subfamily N member 3

Synonyms:

SK3, KCa2.3

Gene ID (NCBI):

140493

Protein function:

Regulates neuronal excitability and afterhyperpolarization via Ca²⁺-activated K⁺ currents

Applications:

Studied in neurophysiology, synaptic signaling, and excitability

Alpk3

|

Alpha kinase 3

Synonyms:

—

Gene ID (NCBI):

116904

Protein function:

Atypical kinase involved in cardiac development and myocyte differentiation

Applications:

Used in cardiac development and disease models

Mta1

|

Metastasis associated 1

Synonyms:

—

Gene ID (NCBI):

116870

Protein function:

Chromatin remodeler; core component of the NuRD complex regulating transcription

Applications:

Studied in chromatin remodeling, transcriptional repression, and cancer

Lsm10

|

LSM10, U7 small nuclear RNA associated

Synonyms:

—

Gene ID (NCBI):

116748

Protein function:

Component of the U7 snRNP complex involved in histone pre-mRNA 3′ end processing

Applications:

Studied in histone processing and RNA splicing

Pawr

|

Prostate apoptosis response 4

Synonyms:

Par-4

Gene ID (NCBI):

114774

Protein function:

Pro-apoptotic protein; regulates NF-κB and tumor suppression pathways

Applications:

Studied in apoptosis, cancer resistance, and stress signaling

Ly6g6d

|

Lymphocyte antigen 6 complex, locus G6D

Synonyms:

—

Gene ID (NCBI):

114654

Protein function:

Cell surface glycoprotein; likely involved in immune cell signaling

Applications:

Used in immunological profiling and Ly6 gene family studies

Brdt

|

Bromodomain testis associated

Synonyms:

BRD6, RING3L

Gene ID (NCBI):

114642

Protein function:

Chromatin reader involved in spermatogenesis and transcriptional regulation

Applications:

Used in reproductive biology and epigenetics research

Ehbp1l1

|

EH domain binding protein 1-like 1

Synonyms:

EHBP1L1

Gene ID (NCBI):

114601

Protein function:

Involved in endocytic recycling and apical trafficking in polarized cells

Applications:

Studied in membrane trafficking and cell polarity

Slc9a4

|

Solute carrier family 9, member A4

Synonyms:

NHE4

Gene ID (NCBI):

110895

Protein function:

Regulates intracellular pH and ion balance in epithelial tissues

Applications:

Used in pH regulation, kidney, and gastric physiology research

Arhgef28

|

Rho guanine nucleotide exchange factor 28

Synonyms:

RGNEF

Gene ID (NCBI):

110596

Protein function:

Activates Rho GTPases; regulates actin cytoskeleton and neuronal signaling

Applications:

Used in motor neuron biology and cytoskeletal signaling studies

C8b

|

Complement component 8, beta polypeptide

Synonyms:

Complement component 8 beta chain

Gene ID (NCBI):

110382

Protein function:

Component of complement membrane attack complex (MAC); essential for innate immunity

Applications:

Studied in innate immunity and complement system

Akr7a5

|

Aldo-keto reductase family 7, member A5

Synonyms:

—

Gene ID (NCBI):

110198

Protein function:

Detoxifies aldehydes and ketones; protects against oxidative stress

Applications:

Studied in xenobiotic metabolism and antioxidant defense

Ampd2

|

Adenosine monophosphate deaminase 2

Synonyms:

—

Gene ID (NCBI):

109674

Protein function:

Catalyzes deamination of AMP to IMP in energy metabolism; heart- and kidney-enriched

Applications:

Studied in purine metabolism and cardiometabolic disorders

Mpi

|

Mannose phosphate isomerase

Synonyms:

MPIase

Gene ID (NCBI):

110119

Protein function:

Converts fructose-6-phosphate to mannose-6-phosphate in glycosylation pathways

Applications:

Used in metabolic disease and glycosylation research

Txlna

|

Taxilin alpha

Synonyms:

Alpha-taxilin

Gene ID (NCBI):

109658

Protein function:

Vesicle trafficking protein involved in exocytosis and SNARE interactions

Applications:

Studied in vesicle fusion and exocytosis pathways

Abraxas2

|

ABRA1-binding protein 2

Synonyms:

FAM175B

Gene ID (NCBI):

109359

Protein function:

Component of BRISC complex; regulates interferon signaling and deubiquitination

Applications:

Used in studies of immune signaling and ubiquitin pathways

Mlec

|

Malectin

Synonyms:

Lectin

Gene ID (NCBI):

109154

Protein function:

ER-resident lectin that binds Glc2-N-glycan intermediates; part of ER quality control

Applications:

Studied in ER protein folding and glycoprotein processing

Rars2

|

Arginyl-tRNA synthetase 2, mitochondrial

Synonyms:

—

Gene ID (NCBI):

109093

Protein function:

Catalyzes aminoacylation of tRNA^Arg in mitochondria

Applications:

Studied in mitochondrial translation and neurodevelopment

Irak2

|

Interleukin-1 receptor-associated kinase 2

Synonyms:

IRAK-2

Gene ID (NCBI):

108960

Protein function:

Mediates signaling for IL-1 and TLRs; involved in NF-κB activation

Applications:

Studied in innate immunity and cytokine signaling

Jmjd1c

|

Jumonji domain containing 1C

Synonyms:

KDM3C, TRIP8

Gene ID (NCBI):

108829

Protein function:

Histone lysine demethylase involved in transcription regulation and germ cell development

Applications:

Studied in epigenetics, spermatogenesis, and cancer

Zzz3

|

Zinc finger ZZ-type containing 3

Synonyms:

ZZZ3

Gene ID (NCBI):

108946

Protein function:

Component of ATAC histone acetyltransferase complex; regulates gene expression

Applications:

Studied in chromatin remodeling and gene activation

Trmt10a

|

TRNA methyltransferase 10A

Synonyms:

RG9MTD2

Gene ID (NCBI):

108943

Protein function:

Methyltransferase involved in tRNA modification (m¹G9 methylation)

Applications:

Studied in tRNA biology, diabetes, and neurodevelopment

Rnf169

|

Ring finger protein 169

Synonyms:

KIAA0196L

Gene ID (NCBI):

108937

Protein function:

Recognizes ubiquitinated histones; regulates DNA damage response (DSB repair)

Applications:

Used in DNA damage response and genome stability studies

Rcc2

|

Regulator of chromosome condensation 2

Synonyms:

TD-60

Gene ID (NCBI):

108911

Protein function:

Regulates mitosis, chromatin condensation, and Rac1 signaling

Applications:

Studied in mitosis and cancer progression

Aif1l

|

Allograft inflammatory factor 1-like

Synonyms:

AIF-1L

Gene ID (NCBI):

108897

Protein function:

Actin-binding protein possibly involved in inflammation and cytoskeletal remodeling

Applications:

Studied in inflammation and muscle development

Edem2

|

ER degradation enhancer, mannosidase alpha-like 2

Synonyms:

Edem-2

Gene ID (NCBI):

108687

Protein function:

Promotes ER-associated degradation (ERAD) of misfolded glycoproteins

Applications:

Studied in protein quality control and ERAD

Prkab2

|

Protein kinase, AMP-activated, beta 2 non-catalytic subunit

Synonyms:

AMPKβ2, AMPKb2

Gene ID (NCBI):

108097

Protein function:

Regulatory subunit of AMPK complex; modulates stability and activity

Applications:

Used in metabolic research and AMPK regulation

Prkaa2

|

Protein kinase, AMP-activated, alpha 2 catalytic subunit

Synonyms:

AMPKα2, AMPKa2

Gene ID (NCBI):

108079

Protein function:

Energy sensor that regulates metabolism under low ATP conditions

Applications:

Studied in energy metabolism and AMPK signaling pathways

Grm6

|

Glutamate receptor, metabotropic 6

Synonyms:

mGluR6

Gene ID (NCBI):

108072

Protein function:

G-protein coupled receptor mediating ON-bipolar cell response in retina

Applications:

Studied in retinal signaling and glutamate pathways

Babam2

|

BRISC and BRCA1 A complex member 2

Synonyms:

MERIT40, NBA1

Gene ID (NCBI):

107976

Protein function:

Regulates BRCA1 recruitment and DNA double-strand break repair

Applications:

Studied in DNA repair, BRCA1 complex, and tumor suppression

Eif2b3

|

Eukaryotic translation initiation factor 2B, subunit 3 gamma

Synonyms:

Eif-2b

Gene ID (NCBI):

108067

Protein function:

Catalyzes GDP–GTP exchange on eIF2; essential for translation initiation

Applications:

Used in translation regulation and neurodegeneration studies

Cth

|

Cystathionine gamma-lyase

Synonyms:

CGL, CSE

Gene ID (NCBI):

107869

Protein function:

Enzyme producing hydrogen sulfide (H₂S); involved in transsulfuration pathway

Applications:

Used in H₂S signaling and sulfur amino acid metabolism studies

Adgrb1

|

Adhesion G protein-coupled receptor B1

Synonyms:

BAI1

Gene ID (NCBI):

107831

Protein function:

GPCR involved in phagocytosis, angiogenesis inhibition, and synaptic regulation

Applications:

Studied in neuroimmunology, angiogenesis, and GPCR signaling

Jmjd6

|

Jumonji domain containing 6

Synonyms:

PSR, PTDSR, Jumonji domain containing 6

Gene ID (NCBI):

107817

Protein function:

Regulates histone modification, RNA splicing, and apoptosis

Applications:

Used in epigenetics, RNA splicing, and immune regulation research

Pdzd8

|

PDZ domain containing 8

Synonyms:

—

Gene ID (NCBI):

107368

Protein function:

Involved in ER-mitochondria tethering and lipid transfer

Applications:

Studied in membrane contact sites and neuronal signaling

Me2

|

Malic enzyme 2, NAD(+)-dependent, mitochondrial

Synonyms:

NAD-ME2

Gene ID (NCBI):

107029

Protein function:

Mitochondrial enzyme converting malate to pyruvate; links TCA cycle and lipid biosynthesis

Applications:

Studied in metabolic regulation and mitochondrial energetics

Ptpn23

|

Protein tyrosine phosphatase, non-receptor type 23

Synonyms:

HD-PTP

Gene ID (NCBI):

104831

Protein function:

Involved in endosomal trafficking and ubiquitin-mediated receptor sorting

Applications:

Used in studies of endocytosis, development, and signaling

Hmgxb3

|

High mobility group box domain containing 3

Synonyms:

—

Gene ID (NCBI):

106894

Protein function:

DNA-binding protein likely involved in transcriptional regulation

Applications:

Used in transcriptional and chromatin structure studies

Osbpl11

|

Oxysterol binding protein-like 11

Synonyms:

ORP11

Gene ID (NCBI):

106326

Protein function:

Lipid transport and signaling; involved in sterol and phospholipid exchange

Applications:

Studied in lipid signaling and membrane contact sites

Ppp4r3b

|

Protein phosphatase 4 regulatory subunit 3B

Synonyms:

SMEK2, C14orf9 (human alias, not used here)

Gene ID (NCBI):

104570

Protein function:

Regulatory subunit of PP4 complex; involved in cell cycle, DNA repair, and neurogenesis

Applications:

Used in neurodevelopment and phosphatase pathway studies

Rexo2

|

RNA exonuclease 2

Synonyms:

RNase D

Gene ID (NCBI):

104444

Protein function:

3'–5' exonuclease involved in RNA processing and mitochondrial RNA degradation

Applications:

Studied in RNA stability and mitochondrial biology

Bap1

|

BRCA1-associated protein 1

Synonyms:

Uchbp

Gene ID (NCBI):

104416

Protein function:

Deubiquitinating enzyme; involved in chromatin remodeling, cell cycle, and tumor suppression

Applications:

Widely used in cancer biology and epigenetic regulation studies

Rcor2

|

REST corepressor 2

Synonyms:

CoREST2

Gene ID (NCBI):

104383

Protein function:

Transcriptional corepressor involved in neural gene silencing; interacts with HDACs

Applications:

Used in neural differentiation and epigenetic repression studies

Zfp119a

|

Zinc finger protein 119A

Synonyms:

Zfp119

Gene ID (NCBI):

104349

Protein function:

Predicted transcription factor; likely involved in gene regulation via zinc finger domains

Applications:

Studied in transcriptional regulation and zinc finger protein function

Synj1

|

Synaptojanin 1

Synonyms:

Synaptojanin 1

Gene ID (NCBI):

104015

Protein function:

Phosphoinositide phosphatase involved in synaptic vesicle recycling

Applications:

Used in neurodegeneration and synaptic plasticity models

Sncb

|

Synuclein beta

Synonyms:

Beta-synuclein

Gene ID (NCBI):

104069

Protein function:

Presynaptic protein modulating dopamine neurotransmission; may protect against α-synuclein aggregation

Applications:

Studied in synucleinopathies and dopamine signaling

Tmem98

|

Transmembrane protein 98

Synonyms:

—

Gene ID (NCBI):

103743

Protein function:

Putative transmembrane protein involved in retinal development and epithelial homeostasis

Applications:

Studied in ocular development and epithelial function

Tbc1d10a

|

TBC1 domain family member 10A

Synonyms:

EPI64, EPI64A

Gene ID (NCBI):

103724

Protein function:

Rab GTPase-activating protein regulating endocytosis and actin remodeling

Applications:

Studied in vesicle recycling and epithelial cell polarity

Sec14l4

|

SEC14-like lipid binding 4

Synonyms:

2900010J08Rik

Gene ID (NCBI):

103655

Protein function:

Predicted lipid transfer protein; possible role in vesicle trafficking or membrane dynamics

Applications:

Used in studies of lipid binding and vesicle transport

Mbtd1

|

Malignant brain tumor domain containing 1

Synonyms:

—

Gene ID (NCBI):

103537

Protein function:

Binds methylated histones; involved in DNA damage repair and transcriptional regulation

Applications:

Studied in chromatin biology and gene expression

Csnk1g2

|

Casein kinase 1 gamma 2

Synonyms:

CK1gamma2

Gene ID (NCBI):

103236

Protein function:

Serine/threonine kinase involved in signal transduction, especially Wnt and Hedgehog pathways

Applications:

Used in signaling pathway research

Xylb

|

Xylulokinase beta

Synonyms:

Xylb1

Gene ID (NCBI):

102448

Protein function:

Catalyzes phosphorylation of xylulose in the pentose metabolism pathway

Applications:

Studied in sugar metabolism and liver function

Pls3

|

Plastin 3

Synonyms:

Tplastin, Plastin 3

Gene ID (NCBI):

102866

Protein function:

Actin-bundling protein involved in cytoskeleton organization and vesicle trafficking

Applications:

Studied in bone biology and neuronal development

Ano10

|

Anoctamin 10

Synonyms:

Tmem16k

Gene ID (NCBI):

102566

Protein function:

Putative calcium-activated chloride channel; involved in vesicle trafficking and membrane dynamics

Applications:

Used in neuroscience and motor coordination models

Ankrd10

|

Ankyrin repeat domain 10

Synonyms:

1110028L23Rik

Gene ID (NCBI):

102334

Protein function:

Contains ankyrin repeats; predicted role in protein-protein interactions and cell signaling

Applications:

Studied in protein interaction and developmental regulation

Unc45a

|

Unc-45 myosin chaperone A

Synonyms:

SMAP-1, Smap1

Gene ID (NCBI):

101869

Protein function:

Acts as a myosin chaperone; regulates cytoskeletal function and cell division

Applications:

Used in studies of cytoskeletal dynamics and motor protein biology

Pds5b

|

PDS5 cohesin-associated factor B

Synonyms:

APRIN, Scc3, 1110028L04Rik

Gene ID (NCBI):

100710

Protein function:

Regulates sister chromatid cohesion and genome stability; interacts with cohesin complex

Applications:

Used in cell cycle, chromosomal stability, and developmental studies

Ttll3

|

Tubulin tyrosine ligase like 3

Synonyms:

4833412B13Rik

Gene ID (NCBI):

101100

Protein function:

Adds glutamate side chains to tubulin; modifies microtubules for stability and function

Applications:

Studied in cilia biology, sperm motility, and microtubule regulation

Smpdl3b

|

Sphingomyelin phosphodiesterase acid-like 3B

Synonyms:

2900026A02Rik

Gene ID (NCBI):

100340

Protein function:

Regulates sphingolipid metabolism and innate immunity

Applications:

Used in innate immunity and membrane lipid studies

Pcsk9

|

Proprotein convertase subtilisin/kexin type 9

Synonyms:

NARC-1

Gene ID (NCBI):

100102

Protein function:

Regulates cholesterol homeostasis by promoting LDLR degradation

Applications:

Widely used in cardiovascular and lipid metabolism models

Trrap

|

Transformation/transcription domain-associated protein

Synonyms:

TRRAP1

Gene ID (NCBI):

100683

Protein function:

Component of histone acetyltransferase complexes; essential for chromatin remodeling and transcriptional activation

Applications:

Studied in chromatin regulation, DNA repair, and transcription

4933434E20Rik

|

RIKEN cDNA 4933434E20 gene

Synonyms:

—

Gene ID (NCBI):

99650

Protein function:

Predicted protein with unknown function; low conservation

Applications:

Used in gene discovery and transcriptomics

Stard7

|

StAR-related lipid transfer domain containing 7

Synonyms:

2310015N10Rik

Gene ID (NCBI):

99138

Protein function:

Lipid transporter of phosphatidylcholine to mitochondria; supports mitochondrial function

Applications:

Used in studies of lipid transport and mitochondrial biology

Wdr47

|

WD repeat domain 47

Synonyms:

1190007D18Rik

Gene ID (NCBI):

99512

Protein function:

Regulates axon extension and ciliary structure through microtubule interactions

Applications:

Studied in neurodevelopment and cilia biology

Eps8l2

|

EPS8-like 2

Synonyms:

2610024H06Rik

Gene ID (NCBI):

98845

Protein function:

Actin cytoskeleton regulator; modulates signaling downstream of EGFR

Applications:

Studied in cell motility, actin regulation, and signal transduction

Nucks1

|

Nuclear casein kinase and cyclin-dependent kinase substrate 1

Synonyms:

NUCKS

Gene ID (NCBI):

98415

Protein function:

Chromatin-associated protein involved in DNA repair and cell cycle regulation

Applications:

Used in DNA repair and transcription regulation studies

Slamf9

|

SLAM family member 9

Synonyms:

CD84H1

Gene ID (NCBI):

98365

Protein function:

Cell surface receptor involved in innate immune responses and macrophage activation

Applications:

Studied in immunology and tumor immunosurveillance

Deptor

|

DEP domain containing MTOR-interacting protein

Synonyms:

DEPDC6

Gene ID (NCBI):

97998

Protein function:

Negative regulator of mTORC1 and mTORC2; modulates metabolism and cell growth

Applications:

Used in cancer, metabolism, and mTOR pathway studies

Ptges2

|

Prostaglandin E synthase 2

Synonyms:

p53N10, mPGE synthase-2

Gene ID (NCBI):

96979

Protein function:

Enzyme converting PGH₂ to PGE₂; regulates inflammatory responses and cell survival

Applications:

Studied in prostaglandin signaling and inflammation models

Rcc1l

|

RCC1 like

Synonyms:

RCCD1

Gene ID (NCBI):

94254

Protein function:

Chromatin-binding protein involved in gene expression and cell cycle regulation

Applications:

Studied in chromatin biology and transcriptional regulation

Lce3c

|

Late cornified envelope 3C

Synonyms:

—

Gene ID (NCBI):

94060

Protein function:

Structural component of the skin barrier; part of the epidermal differentiation complex

Applications:

Studied in epidermal barrier and dermatology research

Hecw1

|

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Synonyms:

NEDL1

Gene ID (NCBI):

94253

Protein function:

E3 ligase involved in p53 regulation and neuronal development

Applications:

Used in studies of ubiquitination, neural development, and motor disorders

Cers1

|

Ceramide synthase 1

Synonyms:

Lass1

Gene ID (NCBI):

93898

Protein function:

Synthesizes C18-ceramides; involved in sphingolipid metabolism and neuronal function

Applications:

Studied in sphingolipid biology, neurology, and apoptosis

P2rx5

|

Purinergic receptor P2X, ligand-gated ion channel, 5

Synonyms:

P2X5

Gene ID (NCBI):

94045

Protein function:

ATP-gated ion channel involved in muscle differentiation and immune signaling

Applications:

Used in purinergic signaling and muscle physiology studies

Sirt1

|

Sirtuin 1

Synonyms:

Sir2, Sir2alpha, SIR2L1

Gene ID (NCBI):

93759

Protein function:

Regulates lifespan, metabolism, inflammation, and gene expression via deacetylation

Applications:

Widely used in aging, metabolism, and chronic disease models

Wnt16

|

Wingless-type MMTV integration site family member 16

Synonyms:

E130309I19Rik

Gene ID (NCBI):

93735

Protein function:

Secreted Wnt ligand regulating bone homeostasis and osteoblast differentiation

Applications:

Used in skeletal development and osteoporosis research

Gabarapl2

|

GABA type A receptor associated protein–like 2

Synonyms:

0610012F20Rik, 2900019O08Rik, GATE‑16, Gef2

Gene ID (NCBI):

93739

Protein function:

ATG8 family autophagy protein involved in autophagosome formation and ER turnover

Applications:

Studied in autophagy, neurobiology, and ER homeostasis

Klf7

|

Kruppel-like transcription factor 7

Synonyms:

9830124P08Rik

Gene ID (NCBI):

93691

Protein function:

Transcription factor involved in neuronal development and axon guidance

Applications:

Used in neurodevelopment and metabolic signaling studies

Clec2i

|

C‑type lectin domain family 2 member i

Synonyms:

Clr‑g, Clrg, Dcl1, LCL‑1, OCILrP2

Gene ID (NCBI):

93675

Protein function:

NK‑cell lectin-like receptor ligand; immune and IL‑2 signaling regulation

Applications:

Studied in NK cell biology and mucosal immunity

Setdb1

|

SET domain, bifurcated 1

Synonyms:

ESET, KMT1E, mKIAA0067

Gene ID (NCBI):

84505

Protein function:

Catalyzes H3K9 methylation; represses transposons and regulates chromatin architecture

Applications:

Used in epigenetics, development, neural maturation, and cancer studies

Cep41

|

Centrosomal protein 41

Synonyms:

1700017E11Rik, 2810431D15Rik, Tsga14

Gene ID (NCBI):

83922

Protein function:

Required for tubulin glutamylation and cilia function in centriole/cilium biogenesis

Applications:

Used in cilia biology, centrosome function, and developmental studies

Slc12a9

|

Solute carrier family 12 member 9

Synonyms:

CIP1, WO3.3, HCCC6, CCC6

Gene ID (NCBI):

83704

Protein function:

Predicted cation‑chloride transporter; possible co-transporter of K⁺/Cl⁻

Applications:

Investigated in solute transport, ion homeostasis, and pharmacogenomics

Tnxb

|

Tenascin XB

Synonyms:

TN‑MHC, Tnx

Gene ID (NCBI):

81877

Protein function:

Extracellular matrix glycoprotein involved in connective tissue structure and wound healing

Applications:

Used in connective tissue, wound healing, and ECM biology studies

Tbl1xr1

|

Transducin (beta)-like 1X‑linked receptor 1

Synonyms:

8030499H02Rik, A630076E03Rik, C21, DC42, Ira1, TBLR1

Gene ID (NCBI):

81004

Protein function:

Corepressor/coactivator in N-CoR/HDAC3 complex; regulates transcription and metabolism

Applications:

Studied in chromatin regulation, nuclear receptor biology, and cancer

Ninl

|

Nin1‑like protein

Synonyms:

—

Gene ID (NCBI):

78177

Protein function:

Centrosomal component regulating microtubule organization and cell division

Applications:

Used in centrosome biology, brain development, and cilia studies

Arl4d

|

ADP‑ribosylation factor‑like 4D

Synonyms:

1110036H21Rik, Arf4l, Arfl4, Arl5

Gene ID (NCBI):

80981

Protein function:

Small GTPase involved in intracellular trafficking and membrane dynamics

Applications:

Used in studies of GTPase signaling and membrane transport

Selenok

|

Selenoprotein K

Synonyms:

Selk, 1110001C03Rik, HSPC030

Gene ID (NCBI):

80795

Protein function:

ER-resident protein involved in calcium flux and immune regulation

Applications:

Used in immunology and ER-stress pathway research

Pacsin3

|

Protein kinase C and casein kinase substrate in neurons 3

Synonyms:

4921507A02Rik, 6330413E15Rik

Gene ID (NCBI):

80708

Protein function:

Regulates membrane curvature, actin remodeling, and endocytosis

Applications:

Used in studies of vesicle trafficking and cytoskeletal biology

Cdk5rap3

|

CDK5 regulatory subunit-associated protein 3

Synonyms:

C53, HSF-27, IC53, LZAP, MST016, 1810007E24Rik

Gene ID (NCBI):

80280

Protein function:

Adapter protein regulating NF-κB, cell cycle, and stress responses

Applications:

Studied in cancer biology and immune signaling pathways

Trim39

|

Tripartite motif-containing 39

Synonyms:

RNF23, TFP, RBCC-B30.2, 1100001D15Rik, E130103K13Rik

Gene ID (NCBI):

79263

Protein function:

E3 ligase involved in ubiquitination and apoptotic signaling

Applications:

Used in studies of ubiquitin signaling and inflammation

Brpf1

|

Bromodomain and PHD finger containing 1 (Peregrin)

Synonyms:

4833438B11Rik, 4930540D11Rik, Br140

Gene ID (NCBI):

78783

Protein function:

Chromatin reader and coactivator; part of MOZ/MORF HAT complexes; regulates H3 acetylation and gene expression

Applications:

Used in chromatin regulation and developmental biology models

Brd8

|

Bromodomain containing 8

Synonyms:

2610007E11Rik, 4432404P07Rik, SMAP

Gene ID (NCBI):

78656

Protein function:

Coactivator for thyroid hormone receptor; contains bromodomain; regulates transcription

Applications:

Used in chromatin and nuclear receptor signaling studies

Bola3

|

BolA family member 3

Synonyms:

1810056O20Rik

Gene ID (NCBI):

78653

Protein function:

Mitochondrial Fe‑S cluster assembly factor; supports lipoylation and oxidative metabolism

Applications:

Model for mitochondrial Fe‑S biogenesis and metabolic disease

8030411F24Rik

|

Cystatin domain containing 1

Synonyms:

Cst14

Gene ID (NCBI):

78609

Protein function:

Predicted cystatin family protease inhibitor

Applications:

Used in gene discovery and cystatin family studies

No results

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

963 models available

Filter with any keyword

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

Discover our

Immunodeficient rodents

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

genO‑BRGSF

Compared to NOD-SCID and NSG, the genO‑BRGSF mouse represents the most adapted animal model to study and predict human immune responses in vivo.

BRGSF

Immunodeficient

genO-SDRG

The immunodeficient genO-SDRG rat model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1^-/- Il2rγ^-/-), resulting in a B, T, and NK cell deficiency.

SDRG

Immunodeficient

genO-Btk rat

genO-Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

BTK

Immunodeficient

KO-Rep-Mix

Discover our customized models

Related resources and publications

malaria

Sonic hedgehog medulloblastomas

GLP1R

Adult-type granulosa cell tumor (AGCT)

castration-resistant metastatic prostate cancer (mCRPC)

CCR8

Chemokine

SIRPα

sirp-alpha

CD137

pulmonary embolism (PE)

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

nutrition

pain research

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

Human immune cell composition of TME depends on tumor cell line-derived xenograft subtype and tumor burden in genO-BRGSF-HIS mice

TME composition in genO-BRGSF-HIS mice

Functional γδ T-cells in genO-BRGSF-HIS mice

genO-BRGSF-HIS for γδ T-cell therapies

Tumor cell line-derived xenograft subtype shapes tumor microenvironment composition in genO-BRGSF-HIS mice

TME composition in genO-BRGSF-HIS mice

Tumor microenvironment composition is shaped by tumor cell line-derived xenograft subtype and tumor burden in BRGSF-HIS mice

TME composition in BRGSF-HIS mice

Assessment of γδ T-cell therapies in humanized mice

BRGSF-HIS for γδ T-cell therapies

BRGSF-HIS mice as a predictive tool for safety assessment of biologics

BRGSF-HIS for safety assessment

(Macomics) Discovery of MACO355: a first in mechanism ligand-blocking independent LILRB1/2/3 antibody for cancer therapy

In vivo tumor growth suppression

Tumor cell line-derived xenograft subtype shapes tumor microenvironment composition in BRGSF-HIS mice

BRGSF-HIS & tumor microenvironment

Myeloid cells' contribution is key in CRS pathophysiology induced by T-cell engagers in BRGSF-HIS model

BRGSF-HIS & myeloid cell compartment in CRS

Cell-depleting agents assessment in preclinical models

BRGSF-HIS & hFcγR to assess cell depletion

Functional human myeloid cells in BRGSF-HIS humanized mice enable myeloid-directed therapy assessment

BRGSF-HIS for myeloid-directed therapy assessment

CD3 humanized mouse models as validated tools to assess immune-related adverse events of T-cell engagers

CD3 and BRGSF-HIS to assess IrAEs

Anti-VISTA agents profiling: complementarity of BRGSF-HIS and hVISTA Knock-in as preclinical models for immunotherapies

BRGSF-HIS & hVISTA for immunotherapies

(Sensei) SNS-101, a monoclonal antibody that is highly selective for VISTA in the tumor microenvironment, demonstrates favorable pharmacokinetic and cytokine release characteristics and potentiates anti-PD-1 responsiveness

VISTA in the tumor microenvironment

Translatable preclinical mouse models for assessment of T-cell engager-induced CRS

BRGSF-HIS & CD3ε in CRS

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Cancer Immunol Res

Efficient generation of human immune system rats using human CD34+ cells

Stem Cell Reports

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

Highlighted article

read the comment

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

Highlighted article

read the comment

Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

JBMRplus

Highlighted article

read the comment

Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity

PLoS One

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF‐A2 humanized mice resemble those in human samples

J Leukoc Biol

Part 2: BRGSF, a new immunodeficient model for immuno-oncology studies

Immuno-oncolology models

Part 3: BRGSF-HIS, a new human immune system mouse model for immuno-oncology studies

Immuno-oncolology models

Deciphering high-dose IL-2 toxicity in reconstituted HIS mice

Immunotherapy in BRGSF-HIS

Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model

PDX in BRGSF-HIS

Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo

Myeloid compartment in BRGSF-HIS

BRGSF-HIS: genOway’s mouse model to evaluate the pathogenesis of Staphylococcus aureus Panton-Valentine leukocidin in acute implant-associated osteomyelitis

BRGSF-HIS as model for acute implant-associated osteomyelitis

No results

Other categories

Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.

Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe