Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.

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Applications

Our immunodeficient models are valuable tools in a wide range of biomedical fields, including oncology, immunology and infectious diseases. Their compromised immune systems allow the engraftment of human tissues, cells (such as human hematopoietic cells) or tumors, making them ideal models for evaluating human immune responses, disease progression and therapeutic interventions. The genetic modifications in our immunodeficient models are designed to reduce the number of murine immune cells while making them more robust and predictable than SCID models.

General model features

Absence of lymphoid cells
Extended lifespan, enabling long-term studies
Robust models with high tolerance to tumor engraftment

Nup88

|

Nucleoporin 88

Synonyms:

Nucleoporin 88kDa, Nup84, Prei2

Gene ID (NCBI):

19069

Protein function:

Component of the nuclear pore complex; involved in nucleocytoplasmic transport.

Applications:

Studies on nuclear transport and gene regulation.

Mapk11

|

Mitogen-activated protein kinase 11

Synonyms:

p38β, SAPK2, PRKM11

Gene ID (NCBI):

19094

Protein function:

Serine/threonine kinase involved in stress response and inflammation signaling.

Applications:

Research on MAPK signaling pathways and inflammation.

Ppp5c

|

Protein phosphatase 5 catalytic subunit

Synonyms:

Protein phosphatase 5, PP5

Gene ID (NCBI):

19060

Protein function:

Serine/threonine phosphatase involved in stress response and cell cycle regulation.

Applications:

Research on stress signaling and cell cycle control.

Ppp3cc

|

Protein phosphatase 3 catalytic subunit gamma

Synonyms:

Calcineurin A gamma, PP2B-A gamma

Gene ID (NCBI):

19057

Protein function:

Calcium/calmodulin-dependent protein phosphatase involved in T-cell activation.

Applications:

Studies on immune signaling and T-cell activation.

Ppm1a

|

Protein phosphatase 1A, magnesium-dependent, alpha isoform

Synonyms:

Protein phosphatase 1A, PP2C-alpha

Gene ID (NCBI):

19042

Protein function:

Serine/threonine phosphatase involved in stress response and cell cycle control.

Applications:

Research on cell cycle and stress signaling pathways.

Plxna2

|

Plexin A2

Synonyms:

KIAA0463, OCT

Gene ID (NCBI):

18845

Protein function:

Receptor for semaphorins; involved in axon guidance and neuronal development.

Applications:

Studies on neural development and guidance cues.

Pa2g4

|

Proliferation-associated 2G4

Synonyms:

EBP1, ErbB3-binding protein 1, p38-2G4

Gene ID (NCBI):

18813

Protein function:

Involved in cell proliferation and differentiation; interacts with ErbB3 receptor.

Applications:

Research on cell cycle regulation and oncology.

Pla2g2c

|

Phospholipase A2 group IIC

Synonyms:

UBXN10-AS1

Gene ID (NCBI):

18781

Protein function:

Enzyme involved in phospholipid metabolism; may play a role in inflammation.

Applications:

Research on lipid metabolism and inflammation.

Prkcz

|

Protein kinase C, zeta

Synonyms:

PKCζ, aPKCζ

Gene ID (NCBI):

18762

Protein function:

Atypical protein kinase C involved in signal transduction pathways.

Applications:

Research on signal transduction and disease mechanisms.

Plau

|

Plasminogen activator, urokinase

Synonyms:

Urokinase-type plasminogen activator, UPA

Gene ID (NCBI):

18792

Protein function:

Converts plasminogen to plasmin, involved in fibrinolysis and tissue remodeling.

Applications:

Studies on cancer progression and thrombosis.

Pkig

|

Protein kinase inhibitor gamma

Synonyms:

PKIγ, cAMP-dependent protein kinase inhibitor gamma

Gene ID (NCBI):

18769

Protein function:

Inhibits cAMP-dependent protein kinase activity, regulating signal transduction pathways.

Applications:

Studies on cAMP signaling and metabolic regulation.

Pdgfrb

|

Platelet derived growth factor receptor beta polypeptide

Synonyms:

PDGFR-β

Gene ID (NCBI):

18596

Protein function:

Receptor tyrosine kinase involved in cell proliferation and development.

Applications:

Studies on angiogenesis and tissue regeneration.

Pfn1

|

Profilin 1

Synonyms:

Profilin 1, actin binding protein

Gene ID (NCBI):

18643

Protein function:

Actin-binding protein regulating cytoskeletal dynamics.

Applications:

Research on cytoskeleton and neurodegenerative diseases.

Pde8a

|

Phosphodiesterase 8A

Synonyms:

Pde8

Gene ID (NCBI):

18584

Protein function:

Enzyme hydrolyzing cAMP, regulating intracellular signaling pathways.

Applications:

Research on signal transduction and pharmacology.

Pitx2

|

Paired-like homeodomain transcription factor 2

Synonyms:

Brx1, Munc30, Rieg

Gene ID (NCBI):

18741

Protein function:

Transcription factor involved in organ development and left-right asymmetry.

Applications:

Studies on developmental biology and congenital disorders.

Pfkl

|

Phosphofructokinase, liver, B-type

Synonyms:

Pfk-liver, Pfk

Gene ID (NCBI):

18641

Protein function:

Key glycolytic enzyme converting fructose-6-phosphate to fructose-1,6-bisphosphate.

Applications:

Studies on energy metabolism and enzymopathies.

Per2

|

Period circadian clock 2

Synonyms:

Period circadian protein homolog 2

Gene ID (NCBI):

18627

Protein function:

Core component of the circadian clock regulating biological rhythms.

Applications:

Research on chronobiology and metabolic regulation.

Pbx3

|

Pre B cell leukemia homeobox 3

Synonyms:

Pre-B-cell leukemia transcription factor 3

Gene ID (NCBI):

18516

Protein function:

Transcription factor involved in developmental processes and hematopoiesis.

Applications:

Research on developmental biology and oncology.

Pcx

|

Pyruvate carboxylase

Synonyms:

Pc

Gene ID (NCBI):

18563

Protein function:

Enzyme catalyzing the carboxylation of pyruvate to oxaloacetate, key in gluconeogenesis.

Applications:

Studies on metabolism and energy homeostasis.

Pax5

|

Paired box 5

Synonyms:

EBB-1, Pax-5

Gene ID (NCBI):

18507

Protein function:

Transcription factor essential for B-cell lineage commitment and development.

Applications:

Studies on immune system development and hematological malignancies.

P2rx7

|

Purinergic receptor P2X, ligand-gated ion channel 7

Synonyms:

P2X7, P2X7R

Gene ID (NCBI):

18439

Protein function:

ATP-gated ion channel involved in inflammation and cell death.

Applications:

Studies on immune response and neuroinflammation.

P2rx4

|

Purinergic receptor P2X, ligand-gated ion channel 4

Synonyms:

P2X4

Gene ID (NCBI):

18438

Protein function:

ATP-gated ion channel involved in synaptic transmission and inflammation.

Applications:

Research on pain mechanisms and vascular function.

P2rx6

|

Purinergic receptor P2X, ligand-gated ion channel 6

Synonyms:

P2X6, P2rxl1, P2xm

Gene ID (NCBI):

18440

Protein function:

ATP-gated ion channel; forms heteromeric channels with other P2X subunits.

Applications:

Research on nociception and vascular biology.

Pak1

|

p21 (RAC1) activated kinase 1

Synonyms:

PAK-1, p21-activated kinase 1

Gene ID (NCBI):

18479

Protein function:

Serine/threonine kinase involved in cytoskeletal remodeling and cell motility.

Applications:

Studies on cell signaling, cancer, and metabolism.

Mybbp1a

|

MYB binding protein (P160) 1a

Synonyms:

P160, Myb-binding protein 1a

Gene ID (NCBI):

18432

Protein function:

Transcriptional regulator involved in ribosome biogenesis and p53 activation.

Applications:

Studies on transcription regulation and tumorigenesis.

Slc25a15

|

Solute carrier family 25 member 15

Synonyms:

Ornt1, D630044L02Rik

Gene ID (NCBI):

18408

Protein function:

Mitochondrial ornithine transporter; essential for urea cycle function.

Applications:

Metabolic disorder models, urea cycle studies.

Nxn

|

Nucleoredoxin

Synonyms:

-

Gene ID (NCBI):

18230

Protein function:

Redox-regulating protein that modulates Wnt signaling by interacting with Dishevelled proteins.

Applications:

Research on redox biology and Wnt signaling.

Ntrk2

|

Neurotrophic tyrosine kinase, receptor, type 2

Synonyms:

TrkB, Trk-B

Gene ID (NCBI):

18212

Protein function:

Receptor for BDNF and NT-4; involved in CNS development and synaptic plasticity.

Applications:

Studies on neurodevelopment and metabolic disorders.

Emc8

|

ER membrane protein complex subunit 8

Synonyms:

-

Gene ID (NCBI):

18117

Protein function:

Part of the ER membrane protein complex; assists in membrane protein insertion.

Applications:

Research on ER function and protein biogenesis.

Ntrk1

|

Neurotrophic tyrosine kinase, receptor, type 1

Synonyms:

TrkA, Trk, Tkr

Gene ID (NCBI):

18211

Protein function:

High-affinity receptor for nerve growth factor; critical for neuronal survival and differentiation.

Applications:

Neurological disorder models, pain research.

Npc1

|

NPC intracellular cholesterol transporter 1

Synonyms:

Niemann-Pick disease, type C1

Gene ID (NCBI):

18145

Protein function:

Mediates intracellular cholesterol trafficking; essential for lipid homeostasis.

Applications:

Models for lipid storage disorders and neurodegeneration.

Nras

|

Neuroblastoma RAS viral oncogene homolog

Synonyms:

N-ras, c-N-Ras

Gene ID (NCBI):

18176

Protein function:

GTPase involved in cell proliferation and differentiation via MAPK/ERK pathway.

Applications:

Cancer research, developmental biology.

Uhrf1

|

Ubiquitin-like with PHD and RING finger domains 1

Synonyms:

ICBP90, Np95

Gene ID (NCBI):

18140

Protein function:

Epigenetic regulator; links DNA methylation and histone modification.

Applications:

Studies on epigenetic regulation and gene silencing.

Notch1

|

Notch 1

Synonyms:

Notch homolog 1

Gene ID (NCBI):

18128

Protein function:

Transmembrane receptor involved in cell fate decisions.

Applications:

Research on cell differentiation and oncogenesis.

Nodal

|

Nodal growth differentiation factor

Synonyms:

-

Gene ID (NCBI):

18119

Protein function:

Secreted ligand of the TGF-beta superfamily; regulates embryonic development.

Applications:

Studies on embryogenesis and developmental biology.

Nmt2

|

N-myristoyltransferase 2

Synonyms:

-

Gene ID (NCBI):

18108

Protein function:

Catalyzes N-terminal myristoylation of proteins; important for membrane targeting.

Applications:

Studies on protein modification and signal transduction.

Nipsnap1

|

Nipsnap homolog 1

Synonyms:

-

Gene ID (NCBI):

18082

Protein function:

Involved in mitophagy and pain transmission.

Applications:

Research on mitochondrial quality control and neuropathies.

Nfatc3

|

Nuclear factor of activated T cells, cytoplasmic 3

Synonyms:

NFAT4, NFATx

Gene ID (NCBI):

18021

Protein function:

Transcription factor involved in immune response regulation.

Applications:

Studies on T-cell activation and immune regulation.

Naga

|

N-acetyl galactosaminidase, alpha

Synonyms:

Alpha-N-acetylgalactosaminidase

Gene ID (NCBI):

17939

Protein function:

Lysosomal enzyme that degrades glycoproteins and glycolipids.

Applications:

Research on lysosomal storage disorders.

Napb

|

N-ethylmaleimide sensitive fusion protein attachment protein beta

Synonyms:

Beta-soluble NSF attachment protein

Gene ID (NCBI):

17957

Protein function:

Involved in vesicle fusion and neurotransmitter release at synapses.

Applications:

Studies on synaptic function and neurological disorders.

Ncoa3

|

Nuclear receptor coactivator 3

Synonyms:

AIB1, SRC-3, RAC3, TRAM-1, pCIP, KAT13B

Gene ID (NCBI):

17979

Protein function:

Coactivator for nuclear receptors; enhances transcriptional activation.

Applications:

Studies on hormone-dependent cancers and gene regulation.

Ncf2

|

Neutrophil cytosolic factor 2

Synonyms:

NOXA2, p67phox

Gene ID (NCBI):

17970

Protein function:

Component of NADPH oxidase complex; generates reactive oxygen species in immune response.

Applications:

Models for studying immune deficiencies and oxidative stress.

Nedd4

|

Neural precursor cell expressed, developmentally down-regulated 4

Synonyms:

Nedd4-1, Nedd4a, E430025J12Rik

Gene ID (NCBI):

17999

Protein function:

E3 ubiquitin-protein ligase; regulates protein degradation.

Applications:

Research on protein ubiquitination and neuronal development.

Myo7a

|

Myosin VIIA

Synonyms:

Usher syndrome type 1B protein

Gene ID (NCBI):

17921

Protein function:

Unconventional myosin involved in sensory functions, including hearing and vision.

Applications:

Studies on sensory organ development and function.

Myl4

|

Myosin, light polypeptide 4

Synonyms:

ALC-1, ELC, ELC1a, GT1, AMLC

Gene ID (NCBI):

17896

Protein function:

Light chain of myosin involved in muscle contraction, especially in atrial muscle.

Applications:

Research on cardiac muscle function and arrhythmias.

Myh9

|

Myosin, heavy polypeptide 9, non-muscle

Synonyms:

NMHC-IIA, NMMHC-IIA

Gene ID (NCBI):

17886

Protein function:

Non-muscle myosin involved in cell motility, adhesion, and cytokinesis.

Applications:

Studies on cytoskeletal dynamics and related diseases.

Myd88

|

Myeloid differentiation primary response gene 88

Synonyms:

-

Gene ID (NCBI):

17874

Protein function:

Adapter protein in Toll-like and IL-1 receptor signaling pathways; crucial for innate immunity.

Applications:

Research on innate immune signaling and inflammation.

Myl2

|

Myosin, light polypeptide 2, regulatory, cardiac, slow

Synonyms:

RLC-2, MLC-2v

Gene ID (NCBI):

17906

Protein function:

Regulatory light chain of myosin in cardiac muscle; modulates contraction.

Applications:

Models for heart development and cardiomyopathy.

Mybpc3

|

Myosin binding protein C, cardiac

Synonyms:

cMyBP-C

Gene ID (NCBI):

17868

Protein function:

Structural protein in cardiac sarcomere; regulates cardiac muscle contraction.

Applications:

Models for cardiomyopathy and heart disease.

Mx1

|

MX dynamin-like GTPase 1

Synonyms:

Mx, Mx-1

Gene ID (NCBI):

17857

Protein function:

Interferon-induced GTPase with antiviral activity against influenza and other viruses.

Applications:

Studies on innate immunity and antiviral responses.

Msh5

|

MutS homolog 5

Synonyms:

G7, MutS homolog 5

Gene ID (NCBI):

17687

Protein function:

DNA mismatch repair protein involved in meiotic recombination and genomic stability.

Applications:

Studies on DNA repair and meiosis.

Cxcl9

|

C-X-C motif chemokine ligand 9

Synonyms:

MIG, CMK, SCYB9, CRG-10

Gene ID (NCBI):

17329

Protein function:

Chemokine induced by interferon-gamma; involved in T-cell trafficking and immune responses.

Applications:

Research on chemokine signaling and immune cell migration.

Mmp16

|

Matrix metallopeptidase 16

Synonyms:

MT3-MMP

Gene ID (NCBI):

17389

Protein function:

Membrane-type metalloproteinase involved in activation of other MMPs and extracellular matrix degradation.

Applications:

Research on extracellular matrix dynamics and cancer.

Mmp12

|

Matrix metallopeptidase 12

Synonyms:

MME, ME, Macrophage elastase

Gene ID (NCBI):

17381

Protein function:

Metalloproteinase involved in extracellular matrix remodeling and tissue repair.

Applications:

Studies on tissue remodeling and inflammatory diseases.

Mapkapk5

|

Mitogen-activated protein kinase-activated protein kinase 5

Synonyms:

MK5, PRAK, MAPKAP-K5

Gene ID (NCBI):

17165

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in cell differentiation and apoptosis.

Applications:

Studies on cell cycle regulation and apoptosis.

Marco

|

Macrophage receptor with collagenous structure

Synonyms:

SCARA2, SR-A6

Gene ID (NCBI):

17167

Protein function:

Scavenger receptor involved in innate immunity and binding of bacterial pathogens.

Applications:

Research on innate immunity and pathogen recognition.

Mgat1

|

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase

Synonyms:

GLCNAC-TI, GLCT1, GLYT1

Gene ID (NCBI):

17308

Protein function:

Enzyme involved in N-glycan biosynthesis; initiates complex N-linked carbohydrate formation.

Applications:

Studies on glycosylation and protein processing.

Mapkapk2

|

Mitogen-activated protein kinase-activated protein kinase 2

Synonyms:

MK2, MAPKAP-K2

Gene ID (NCBI):

17164

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in stress and inflammatory responses.

Applications:

Research on inflammation and stress signaling pathways.

Lyn

|

LYN proto-oncogene, Src family tyrosine kinase

Synonyms:

p53Lyn, p56Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Gene ID (NCBI):

17096

Protein function:

Non-receptor tyrosine kinase involved in B-cell receptor signaling and regulation of immune responses.

Applications:

Studies on immune signaling and autoimmune disorders.

Cep250

|

Centrosomal protein 250

Synonyms:

C-Nap1

Gene ID (NCBI):

16328

Protein function:

Component of the centrosome involved in centrosome cohesion during interphase.

Applications:

Studies on cell division and sensory disorders.

Lrrc23

|

Leucine rich repeat containing 23

Synonyms:

LRPB7, Leucine-rich repeat-containing protein 23

Gene ID (NCBI):

16977

Protein function:

Predicted to be involved in sperm motility and radial spoke assembly; contains leucine-rich repeats.

Applications:

Studies on reproductive biology and ciliary function.

Lrmp

|

Lymphoid-restricted membrane protein

Synonyms:

IRAG2, JAW1, Lymphoid-restricted membrane protein

Gene ID (NCBI):

16970

Protein function:

Involved in calcium signaling and immune cell function; interacts with inositol 1,4,5-trisphosphate receptors.

Applications:

Research on lymphocyte signaling and immune responses.

Lmnb1

|

Lamin B1

Synonyms:

Lamin B1

Gene ID (NCBI):

16906

Protein function:

Structural component of the nuclear lamina; maintains nuclear integrity and regulates gene expression.

Applications:

Studies on nuclear architecture and neurodegenerative diseases.

Lifr

|

Leukemia inhibitory factor receptor

Synonyms:

LIF receptor subunit alpha, CD118

Gene ID (NCBI):

16880

Protein function:

Receptor for leukemia inhibitory factor; involved in cell differentiation, survival, and proliferation.

Applications:

Research on cytokine signaling and developmental biology.

Lepr

|

Leptin receptor

Synonyms:

LEP-R, OB-R, CD295, LEPRD, DB

Gene ID (NCBI):

16847

Protein function:

Receptor for leptin; regulates body weight, energy expenditure, and neuroendocrine function.

Applications:

Studies on obesity, metabolism, and endocrine function.

Ldlr

|

Low density lipoprotein receptor

Synonyms:

Low-density lipoprotein receptor, Hlb301

Gene ID (NCBI):

16835

Protein function:

Mediates endocytosis of cholesterol-rich LDL particles; crucial for cholesterol homeostasis.

Applications:

Research on lipid metabolism and cardiovascular diseases.

Ldha

|

Lactate dehydrogenase A

Synonyms:

Ldh1, Ldhm, L7R2

Gene ID (NCBI):

16828

Protein function:

Catalyzes conversion of pyruvate to lactate during anaerobic glycolysis; important in muscle metabolism.

Applications:

Studies on energy metabolism and cancer.

Lama1

|

Laminin subunit alpha-1

Synonyms:

Laminin A chain, Laminin-1 subunit alpha, S-LAM alpha

Gene ID (NCBI):

16772

Protein function:

Major component of basement membranes; involved in cell adhesion, differentiation, and migration.

Applications:

Studies on extracellular matrix and developmental biology.

Lbp

|

Lipopolysaccharide binding protein

Synonyms:

Lipopolysaccharide-binding protein, Bpifd2

Gene ID (NCBI):

16803

Protein function:

Binds bacterial lipopolysaccharides (LPS) and transfers them to CD14 and TLR4, initiating immune responses.

Applications:

Research on innate immunity and sepsis models.

Klkb1

|

Kallikrein B, plasma 1

Synonyms:

Plasma kallikrein

Gene ID (NCBI):

16621

Protein function:

Serine protease involved in the kallikrein-kinin system, affecting blood pressure and inflammation.

Applications:

Research on coagulation and inflammatory pathways.

Sspn

|

Sarcospan

Synonyms:

Sarcospan

Gene ID (NCBI):

16651

Protein function:

Component of the dystrophin-glycoprotein complex, contributing to muscle membrane stability.

Applications:

Studies on muscle integrity and dystrophin complex.

Aff3

|

AF4/FMR2 family member 3

Synonyms:

LAF4

Gene ID (NCBI):

16764

Protein function:

Transcriptional activator involved in lymphoid development and gene regulation.

Applications:

Research on transcriptional regulation and lymphoid development.

Kif3b

|

Kinesin family member 3B

Synonyms:

-

Gene ID (NCBI):

16569

Protein function:

Component of the kinesin-II complex involved in intraflagellar transport and cilia function.

Applications:

Studies on cilia function and embryonic development.

Kcnj12

|

Potassium inwardly-rectifying channel, subfamily J, member 12

Synonyms:

Kir2.2

Gene ID (NCBI):

16515

Protein function:

Inward rectifier potassium channel contributing to cardiac and skeletal muscle excitability.

Applications:

Research on cardiac electrophysiology and muscle function.

Kif13b

|

Kinesin family member 13B

Synonyms:

GAKIN

Gene ID (NCBI):

16554

Protein function:

Microtubule-based motor protein involved in intracellular transport and myelination.

Applications:

Research on axonal transport and myelination.

Kcnj9

|

Potassium inwardly-rectifying channel, subfamily J, member 9

Synonyms:

Kir3.3

Gene ID (NCBI):

16524

Protein function:

G protein-activated inward rectifier potassium channel involved in regulating neuronal excitability.

Applications:

Studies on G protein signaling and neuronal function.

Kcnj11

|

Potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:

Kir6.2

Gene ID (NCBI):

16514

Protein function:

Forms ATP-sensitive potassium channels regulating insulin secretion in pancreatic beta cells.

Applications:

Studies on insulin secretion and diabetes.

Kcnb1

|

Potassium voltage-gated channel subfamily B member 1

Synonyms:

Kv2.1

Gene ID (NCBI):

16500

Protein function:

Delayed rectifier potassium channel involved in action potential repolarization in neurons.

Applications:

Research on neuronal excitability and epilepsy.

Itgae

|

Integrin alpha E

Synonyms:

CD103

Gene ID (NCBI):

16407

Protein function:

Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.

Applications:

Studies on mucosal immunity and T-cell localization.

Itga2

|

Integrin subunit alpha 2

Synonyms:

Integrin alpha-2, CD49b

Gene ID (NCBI):

16398

Protein function:

Integrin alpha chain involved in cell adhesion and recognition in a variety of processes including embryogenesis and hemostasis.

Applications:

Research on cell adhesion and hemostasis.

Il15

|

Interleukin 15

Synonyms:

IL-15

Gene ID (NCBI):

16168

Protein function:

Cytokine that stimulates the proliferation of T lymphocytes and is involved in the development of NK cells.

Applications:

Research on immune cell development and cytokine therapy.

Itch

|

Itchy homolog (mouse)

Synonyms:

Itchy E3 ubiquitin protein ligase

Gene ID (NCBI):

16396

Protein function:

E3 ubiquitin ligase involved in the regulation of immune responses and protein degradation.

Applications:

Studies on protein ubiquitination and immune regulation.

Irf1

|

Interferon regulatory factor 1

Synonyms:

IRF-1

Gene ID (NCBI):

16362

Protein function:

Transcription factor that regulates the expression of interferons and other genes involved in immune responses.

Applications:

Research on immune regulation and transcriptional control.

Irak1

|

Interleukin-1 receptor-associated kinase 1

Synonyms:

IRAK-1

Gene ID (NCBI):

16179

Protein function:

Kinase involved in the Toll-like receptor and IL-1 receptor signaling pathways, leading to NF-κB activation.

Applications:

Studies on innate immunity and inflammatory signaling.

Lrig1

|

Leucine-rich repeats and immunoglobulin-like domains 1

Synonyms:

LRIG1

Gene ID (NCBI):

16206

Protein function:

Transmembrane protein that negatively regulates receptor tyrosine kinases, involved in stem cell maintenance.

Applications:

Research on stem cell biology and cancer.

Id2

|

Inhibitor of DNA Binding 2

Synonyms:

-

Gene ID (NCBI):

15902

Protein function:

Transcriptional regulator that inhibits DNA binding of basic helix-loop-helix proteins.

Applications:

Immune system and developmental studies

Ido1

|

Indoleamine 2,3-Dioxygenase 1

Synonyms:

-

Gene ID (NCBI):

15930

Protein function:

Catalyzes the first step in tryptophan catabolism; modulates immune response.

Applications:

Immunotherapy and metabolic studies

Il12a

|

Interleukin 12a

Synonyms:

IL-12p35

Gene ID (NCBI):

16159

Protein function:

Subunit of the cytokine IL-12, involved in the differentiation of naive T cells into Th1 cells.

Applications:

Research on immune responses and cytokine signaling.

Il13ra2

|

Interleukin 13 receptor, alpha 2

Synonyms:

IL-13Rα2

Gene ID (NCBI):

16165

Protein function:

High-affinity receptor for IL-13, acts as a decoy receptor modulating IL-13 activity.

Applications:

Studies on cytokine signaling and immune regulation.

Ikbkb

|

Inhibitor of kappaB kinase beta

Synonyms:

IKKβ, IKK2

Gene ID (NCBI):

16150

Protein function:

Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.

Applications:

Studies on NF-κB signaling, inflammation, and immune responses.

Ifnar1

|

Interferon Alpha and Beta Receptor Subunit 1

Synonyms:

Ifar, Ifrc

Gene ID (NCBI):

15975

Protein function:

Part of the receptor for type I interferons; mediates antiviral responses.

Applications:

Viral infection and immune response studies

Ide

|

Insulin Degrading Enzyme

Synonyms:

-

Gene ID (NCBI):

15925

Protein function:

Degrades insulin and other peptides; involved in glucose metabolism.

Applications:

Metabolic and neurodegenerative disease models

Prmt1

|

Protein Arginine Methyltransferase 1

Synonyms:

Hrmt1l2

Gene ID (NCBI):

15469

Protein function:

Major type I arginine methyltransferase; modifies histones and other proteins.

Applications:

Gene expression and developmental studies

Trmt2a

|

tRNA Methyltransferase 2 Homolog A

Synonyms:

-

Gene ID (NCBI):

15547

Protein function:

Methylates uridine residues in tRNA; involved in RNA processing.

Applications:

RNA modification and processing studies

Prmt2

|

Protein Arginine Methyltransferase 2

Synonyms:

Hrmt1l1

Gene ID (NCBI):

15468

Protein function:

Enzyme that methylates arginine residues on histones and other proteins.

Applications:

Epigenetic regulation and developmental studies

Hprt

|

Hypoxanthine Phosphoribosyltransferase 1

Synonyms:

Hprt1

Gene ID (NCBI):

15452

Protein function:

Enzyme in purine salvage pathway; converts hypoxanthine to IMP.

Applications:

Purine metabolism and neurological disorder models

Hp1bp3

|

Heterochromatin Protein 1 Binding Protein 3

Synonyms:

Hp1bp74

Gene ID (NCBI):

15441

Protein function:

Chromatin-binding protein involved in gene expression regulation.

Applications:

Epigenetics and gene expression studies

Hira

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Histone cell cycle regulator

Synonyms:

DiGeorge syndrome critical region gene 1

Gene ID (NCBI):

15260

Protein function:

Histone chaperone involved in nucleosome assembly and chromatin remodeling.

Applications:

Research on chromatin assembly and developmental biology.

Hoxa2

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Homeobox A2

Synonyms:

Hox-1.11, Hox1a

Gene ID (NCBI):

15399

Protein function:

Transcription factor involved in craniofacial and skeletal development.

Applications:

Craniofacial development studies

Hmox2

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Heme oxygenase 2

Synonyms:

HO-2, HO2

Gene ID (NCBI):

15369

Protein function:

Enzyme that degrades heme to biliverdin, carbon monoxide, and free iron.

Applications:

Studies on oxidative stress and neuroprotection.

No results

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Immunodeficient rodents

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genO‑BRGSF

Compared to NOD-SCID and NSG, the genO‑BRGSF mouse represents the most adapted animal model to study and predict human immune responses in vivo.

BRGSF

Immunodeficient

genO-SDRG

The immunodeficient genO-SDRG rat model is a double Knockout for Rag1 and IL-2Rγ genes (Rag1^-/- Il2rγ^-/-), resulting in a B, T, and NK cell deficiency.

SDRG

Immunodeficient

genO-Btk rat

genO-Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

BTK

Immunodeficient

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Human immune cell composition of TME depends on tumor cell line-derived xenograft subtype and tumor burden in genO-BRGSF-HIS mice

TME composition in genO-BRGSF-HIS mice

Functional γδ T-cells in genO-BRGSF-HIS mice

genO-BRGSF-HIS for γδ T-cell therapies

Tumor cell line-derived xenograft subtype shapes tumor microenvironment composition in genO-BRGSF-HIS mice

TME composition in genO-BRGSF-HIS mice

Tumor microenvironment composition is shaped by tumor cell line-derived xenograft subtype and tumor burden in BRGSF-HIS mice

TME composition in BRGSF-HIS mice

Assessment of γδ T-cell therapies in humanized mice

BRGSF-HIS for γδ T-cell therapies

BRGSF-HIS mice as a predictive tool for safety assessment of biologics

BRGSF-HIS for safety assessment

(Macomics) Discovery of MACO355: a first in mechanism ligand-blocking independent LILRB1/2/3 antibody for cancer therapy

In vivo tumor growth suppression

Tumor cell line-derived xenograft subtype shapes tumor microenvironment composition in BRGSF-HIS mice

BRGSF-HIS & tumor microenvironment

Myeloid cells' contribution is key in CRS pathophysiology induced by T-cell engagers in BRGSF-HIS model

BRGSF-HIS & myeloid cell compartment in CRS

Cell-depleting agents assessment in preclinical models

BRGSF-HIS & hFcγR to assess cell depletion

Functional human myeloid cells in BRGSF-HIS humanized mice enable myeloid-directed therapy assessment

BRGSF-HIS for myeloid-directed therapy assessment

CD3 humanized mouse models as validated tools to assess immune-related adverse events of T-cell engagers

CD3 and BRGSF-HIS to assess IrAEs

Anti-VISTA agents profiling: complementarity of BRGSF-HIS and hVISTA Knock-in as preclinical models for immunotherapies

BRGSF-HIS & hVISTA for immunotherapies

(Sensei) SNS-101, a monoclonal antibody that is highly selective for VISTA in the tumor microenvironment, demonstrates favorable pharmacokinetic and cytokine release characteristics and potentiates anti-PD-1 responsiveness

VISTA in the tumor microenvironment

Translatable preclinical mouse models for assessment of T-cell engager-induced CRS

BRGSF-HIS & CD3ε in CRS

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Cancer Immunol Res

Efficient generation of human immune system rats using human CD34+ cells

Stem Cell Reports

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

Highlighted article

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Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

Highlighted article

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Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

JBMRplus

Highlighted article

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Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity

PLoS One

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF‐A2 humanized mice resemble those in human samples

J Leukoc Biol

Part 2: BRGSF, a new immunodeficient model for immuno-oncology studies

Immuno-oncolology models

Part 3: BRGSF-HIS, a new human immune system mouse model for immuno-oncology studies

Immuno-oncolology models

Deciphering high-dose IL-2 toxicity in reconstituted HIS mice

Immunotherapy in BRGSF-HIS

Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model

PDX in BRGSF-HIS

Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo

Myeloid compartment in BRGSF-HIS

BRGSF-HIS: genOway’s mouse model to evaluate the pathogenesis of Staphylococcus aureus Panton-Valentine leukocidin in acute implant-associated osteomyelitis

BRGSF-HIS as model for acute implant-associated osteomyelitis

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Other categories

Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.

Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.