Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Immune checkpoint cell lines

Our humanized and Knockout immune checkpoint cell lines represent cutting-edge advancements in the field of immuno-oncology research. These meticulously engineered cell lines play a pivotal role in unraveling the complexities of immune responses and checkpoint regulation.

The Humanized cell lines are tailored to express human immune checkpoint proteins, providing a more accurate reflection of human immune system behavior.

On the other hand, the Knockout cell lines involve the targeted inactivation of specific immune checkpoint genes, allowing researchers to study the effects of these alterations on immune function.

These innovative cell lines serve as invaluable tools for exploring the intricate mechanisms of immune checkpoint pathways, paving the way for advancements in immunotherapy and contributing significantly to the development of novel therapeutic strategies.

Msh5

|

MutS homolog 5

Synonyms:

G7, MutS homolog 5

Gene ID (NCBI):

17687

Protein function:

DNA mismatch repair protein involved in meiotic recombination and genomic stability.

Applications:

Studies on DNA repair and meiosis.

Cxcl9

|

C-X-C motif chemokine ligand 9

Synonyms:

MIG, CMK, SCYB9, CRG-10

Gene ID (NCBI):

17329

Protein function:

Chemokine induced by interferon-gamma; involved in T-cell trafficking and immune responses.

Applications:

Research on chemokine signaling and immune cell migration.

Mmp16

|

Matrix metallopeptidase 16

Synonyms:

MT3-MMP

Gene ID (NCBI):

17389

Protein function:

Membrane-type metalloproteinase involved in activation of other MMPs and extracellular matrix degradation.

Applications:

Research on extracellular matrix dynamics and cancer.

Mmp12

|

Matrix metallopeptidase 12

Synonyms:

MME, ME, Macrophage elastase

Gene ID (NCBI):

17381

Protein function:

Metalloproteinase involved in extracellular matrix remodeling and tissue repair.

Applications:

Studies on tissue remodeling and inflammatory diseases.

Mapkapk5

|

Mitogen-activated protein kinase-activated protein kinase 5

Synonyms:

MK5, PRAK, MAPKAP-K5

Gene ID (NCBI):

17165

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in cell differentiation and apoptosis.

Applications:

Studies on cell cycle regulation and apoptosis.

Marco

|

Macrophage receptor with collagenous structure

Synonyms:

SCARA2, SR-A6

Gene ID (NCBI):

17167

Protein function:

Scavenger receptor involved in innate immunity and binding of bacterial pathogens.

Applications:

Research on innate immunity and pathogen recognition.

Mgat1

|

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase

Synonyms:

GLCNAC-TI, GLCT1, GLYT1

Gene ID (NCBI):

17308

Protein function:

Enzyme involved in N-glycan biosynthesis; initiates complex N-linked carbohydrate formation.

Applications:

Studies on glycosylation and protein processing.

Mapkapk2

|

Mitogen-activated protein kinase-activated protein kinase 2

Synonyms:

MK2, MAPKAP-K2

Gene ID (NCBI):

17164

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in stress and inflammatory responses.

Applications:

Research on inflammation and stress signaling pathways.

Lyn

|

LYN proto-oncogene, Src family tyrosine kinase

Synonyms:

p53Lyn, p56Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Gene ID (NCBI):

17096

Protein function:

Non-receptor tyrosine kinase involved in B-cell receptor signaling and regulation of immune responses.

Applications:

Studies on immune signaling and autoimmune disorders.

Cep250

|

Centrosomal protein 250

Synonyms:

C-Nap1

Gene ID (NCBI):

16328

Protein function:

Component of the centrosome involved in centrosome cohesion during interphase.

Applications:

Studies on cell division and sensory disorders.

Lrrc23

|

Leucine rich repeat containing 23

Synonyms:

LRPB7, Leucine-rich repeat-containing protein 23

Gene ID (NCBI):

16977

Protein function:

Predicted to be involved in sperm motility and radial spoke assembly; contains leucine-rich repeats.

Applications:

Studies on reproductive biology and ciliary function.

Lrmp

|

Lymphoid-restricted membrane protein

Synonyms:

IRAG2, JAW1, Lymphoid-restricted membrane protein

Gene ID (NCBI):

16970

Protein function:

Involved in calcium signaling and immune cell function; interacts with inositol 1,4,5-trisphosphate receptors.

Applications:

Research on lymphocyte signaling and immune responses.

Lmnb1

|

Lamin B1

Synonyms:

Lamin B1

Gene ID (NCBI):

16906

Protein function:

Structural component of the nuclear lamina; maintains nuclear integrity and regulates gene expression.

Applications:

Studies on nuclear architecture and neurodegenerative diseases.

Lifr

|

Leukemia inhibitory factor receptor

Synonyms:

LIF receptor subunit alpha, CD118

Gene ID (NCBI):

16880

Protein function:

Receptor for leukemia inhibitory factor; involved in cell differentiation, survival, and proliferation.

Applications:

Research on cytokine signaling and developmental biology.

Lepr

|

Leptin receptor

Synonyms:

LEP-R, OB-R, CD295, LEPRD, DB

Gene ID (NCBI):

16847

Protein function:

Receptor for leptin; regulates body weight, energy expenditure, and neuroendocrine function.

Applications:

Studies on obesity, metabolism, and endocrine function.

Ldlr

|

Low density lipoprotein receptor

Synonyms:

Low-density lipoprotein receptor, Hlb301

Gene ID (NCBI):

16835

Protein function:

Mediates endocytosis of cholesterol-rich LDL particles; crucial for cholesterol homeostasis.

Applications:

Research on lipid metabolism and cardiovascular diseases.

Ldha

|

Lactate dehydrogenase A

Synonyms:

Ldh1, Ldhm, L7R2

Gene ID (NCBI):

16828

Protein function:

Catalyzes conversion of pyruvate to lactate during anaerobic glycolysis; important in muscle metabolism.

Applications:

Studies on energy metabolism and cancer.

Lama1

|

Laminin subunit alpha-1

Synonyms:

Laminin A chain, Laminin-1 subunit alpha, S-LAM alpha

Gene ID (NCBI):

16772

Protein function:

Major component of basement membranes; involved in cell adhesion, differentiation, and migration.

Applications:

Studies on extracellular matrix and developmental biology.

Lbp

|

Lipopolysaccharide binding protein

Synonyms:

Lipopolysaccharide-binding protein, Bpifd2

Gene ID (NCBI):

16803

Protein function:

Binds bacterial lipopolysaccharides (LPS) and transfers them to CD14 and TLR4, initiating immune responses.

Applications:

Research on innate immunity and sepsis models.

Klkb1

|

Kallikrein B, plasma 1

Synonyms:

Plasma kallikrein

Gene ID (NCBI):

16621

Protein function:

Serine protease involved in the kallikrein-kinin system, affecting blood pressure and inflammation.

Applications:

Research on coagulation and inflammatory pathways.

Sspn

|

Sarcospan

Synonyms:

Sarcospan

Gene ID (NCBI):

16651

Protein function:

Component of the dystrophin-glycoprotein complex, contributing to muscle membrane stability.

Applications:

Studies on muscle integrity and dystrophin complex.

Aff3

|

AF4/FMR2 family member 3

Synonyms:

LAF4

Gene ID (NCBI):

16764

Protein function:

Transcriptional activator involved in lymphoid development and gene regulation.

Applications:

Research on transcriptional regulation and lymphoid development.

Kif3b

|

Kinesin family member 3B

Synonyms:

-

Gene ID (NCBI):

16569

Protein function:

Component of the kinesin-II complex involved in intraflagellar transport and cilia function.

Applications:

Studies on cilia function and embryonic development.

Kcnj12

|

Potassium inwardly-rectifying channel, subfamily J, member 12

Synonyms:

Kir2.2

Gene ID (NCBI):

16515

Protein function:

Inward rectifier potassium channel contributing to cardiac and skeletal muscle excitability.

Applications:

Research on cardiac electrophysiology and muscle function.

Kif13b

|

Kinesin family member 13B

Synonyms:

GAKIN

Gene ID (NCBI):

16554

Protein function:

Microtubule-based motor protein involved in intracellular transport and myelination.

Applications:

Research on axonal transport and myelination.

Kcnj9

|

Potassium inwardly-rectifying channel, subfamily J, member 9

Synonyms:

Kir3.3

Gene ID (NCBI):

16524

Protein function:

G protein-activated inward rectifier potassium channel involved in regulating neuronal excitability.

Applications:

Studies on G protein signaling and neuronal function.

Kcnj11

|

Potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:

Kir6.2

Gene ID (NCBI):

16514

Protein function:

Forms ATP-sensitive potassium channels regulating insulin secretion in pancreatic beta cells.

Applications:

Studies on insulin secretion and diabetes.

Kcnb1

|

Potassium voltage-gated channel subfamily B member 1

Synonyms:

Kv2.1

Gene ID (NCBI):

16500

Protein function:

Delayed rectifier potassium channel involved in action potential repolarization in neurons.

Applications:

Research on neuronal excitability and epilepsy.

Itgae

|

Integrin alpha E

Synonyms:

CD103

Gene ID (NCBI):

16407

Protein function:

Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.

Applications:

Studies on mucosal immunity and T-cell localization.

Itga2

|

Integrin subunit alpha 2

Synonyms:

Integrin alpha-2, CD49b

Gene ID (NCBI):

16398

Protein function:

Integrin alpha chain involved in cell adhesion and recognition in a variety of processes including embryogenesis and hemostasis.

Applications:

Research on cell adhesion and hemostasis.

Il15

|

Interleukin 15

Synonyms:

IL-15

Gene ID (NCBI):

16168

Protein function:

Cytokine that stimulates the proliferation of T lymphocytes and is involved in the development of NK cells.

Applications:

Research on immune cell development and cytokine therapy.

Itch

|

Itchy homolog (mouse)

Synonyms:

Itchy E3 ubiquitin protein ligase

Gene ID (NCBI):

16396

Protein function:

E3 ubiquitin ligase involved in the regulation of immune responses and protein degradation.

Applications:

Studies on protein ubiquitination and immune regulation.

Irf1

|

Interferon regulatory factor 1

Synonyms:

IRF-1

Gene ID (NCBI):

16362

Protein function:

Transcription factor that regulates the expression of interferons and other genes involved in immune responses.

Applications:

Research on immune regulation and transcriptional control.

Irak1

|

Interleukin-1 receptor-associated kinase 1

Synonyms:

IRAK-1

Gene ID (NCBI):

16179

Protein function:

Kinase involved in the Toll-like receptor and IL-1 receptor signaling pathways, leading to NF-κB activation.

Applications:

Studies on innate immunity and inflammatory signaling.

Lrig1

|

Leucine-rich repeats and immunoglobulin-like domains 1

Synonyms:

LRIG1

Gene ID (NCBI):

16206

Protein function:

Transmembrane protein that negatively regulates receptor tyrosine kinases, involved in stem cell maintenance.

Applications:

Research on stem cell biology and cancer.

Id2

|

Inhibitor of DNA Binding 2

Synonyms:

-

Gene ID (NCBI):

15902

Protein function:

Transcriptional regulator that inhibits DNA binding of basic helix-loop-helix proteins.

Applications:

Immune system and developmental studies

Ido1

|

Indoleamine 2,3-Dioxygenase 1

Synonyms:

-

Gene ID (NCBI):

15930

Protein function:

Catalyzes the first step in tryptophan catabolism; modulates immune response.

Applications:

Immunotherapy and metabolic studies

Il12a

|

Interleukin 12a

Synonyms:

IL-12p35

Gene ID (NCBI):

16159

Protein function:

Subunit of the cytokine IL-12, involved in the differentiation of naive T cells into Th1 cells.

Applications:

Research on immune responses and cytokine signaling.

Il13ra2

|

Interleukin 13 receptor, alpha 2

Synonyms:

IL-13Rα2

Gene ID (NCBI):

16165

Protein function:

High-affinity receptor for IL-13, acts as a decoy receptor modulating IL-13 activity.

Applications:

Studies on cytokine signaling and immune regulation.

Ikbkb

|

Inhibitor of kappaB kinase beta

Synonyms:

IKKβ, IKK2

Gene ID (NCBI):

16150

Protein function:

Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.

Applications:

Studies on NF-κB signaling, inflammation, and immune responses.

Ifnar1

|

Interferon Alpha and Beta Receptor Subunit 1

Synonyms:

Ifar, Ifrc

Gene ID (NCBI):

15975

Protein function:

Part of the receptor for type I interferons; mediates antiviral responses.

Applications:

Viral infection and immune response studies

Ide

|

Insulin Degrading Enzyme

Synonyms:

-

Gene ID (NCBI):

15925

Protein function:

Degrades insulin and other peptides; involved in glucose metabolism.

Applications:

Metabolic and neurodegenerative disease models

Prmt1

|

Protein Arginine Methyltransferase 1

Synonyms:

Hrmt1l2

Gene ID (NCBI):

15469

Protein function:

Major type I arginine methyltransferase; modifies histones and other proteins.

Applications:

Gene expression and developmental studies

Trmt2a

|

tRNA Methyltransferase 2 Homolog A

Synonyms:

-

Gene ID (NCBI):

15547

Protein function:

Methylates uridine residues in tRNA; involved in RNA processing.

Applications:

RNA modification and processing studies

Prmt2

|

Protein Arginine Methyltransferase 2

Synonyms:

Hrmt1l1

Gene ID (NCBI):

15468

Protein function:

Enzyme that methylates arginine residues on histones and other proteins.

Applications:

Epigenetic regulation and developmental studies

Hprt

|

Hypoxanthine Phosphoribosyltransferase 1

Synonyms:

Hprt1

Gene ID (NCBI):

15452

Protein function:

Enzyme in purine salvage pathway; converts hypoxanthine to IMP.

Applications:

Purine metabolism and neurological disorder models

Hp1bp3

|

Heterochromatin Protein 1 Binding Protein 3

Synonyms:

Hp1bp74

Gene ID (NCBI):

15441

Protein function:

Chromatin-binding protein involved in gene expression regulation.

Applications:

Epigenetics and gene expression studies

Hira

|

Histone cell cycle regulator

Synonyms:

DiGeorge syndrome critical region gene 1

Gene ID (NCBI):

15260

Protein function:

Histone chaperone involved in nucleosome assembly and chromatin remodeling.

Applications:

Research on chromatin assembly and developmental biology.

Hoxa2

|

Homeobox A2

Synonyms:

Hox-1.11, Hox1a

Gene ID (NCBI):

15399

Protein function:

Transcription factor involved in craniofacial and skeletal development.

Applications:

Craniofacial development studies

Hmox2

|

Heme oxygenase 2

Synonyms:

HO-2, HO2

Gene ID (NCBI):

15369

Protein function:

Enzyme that degrades heme to biliverdin, carbon monoxide, and free iron.

Applications:

Studies on oxidative stress and neuroprotection.

Hnf4a

|

Hepatocyte nuclear factor 4 alpha

Synonyms:

HNF-4alpha, MODY1, NR2A1

Gene ID (NCBI):

15378

Protein function:

Nuclear receptor that regulates gene expression in liver and pancreas.

Applications:

Models for diabetes and metabolic disorders.

Hint1

|

Histidine triad nucleotide-binding protein 1

Synonyms:

PKCI-1

Gene ID (NCBI):

15254

Protein function:

Involved in transcriptional regulation and apoptosis; acts as a tumor suppressor.

Applications:

Research on tumor suppression and neuromuscular disorders.

Hipk3

|

Homeodomain interacting protein kinase 3

Synonyms:

DYRK6, FIST3, PKY

Gene ID (NCBI):

15259

Protein function:

Serine/threonine kinase involved in transcriptional regulation and apoptosis.

Applications:

Studies on cell proliferation, apoptosis, and metabolic diseases.

Hdac3

|

Histone deacetylase 3

Synonyms:

Rpd3-2

Gene ID (NCBI):

15183

Protein function:

Enzyme that removes acetyl groups from histones, leading to chromatin condensation and transcriptional repression.

Applications:

Epigenetic regulation studies, cancer research, neurobiology.

Hgs

|

Hepatocyte growth factor-regulated tyrosine kinase substrate

Synonyms:

Hrs

Gene ID (NCBI):

15239

Protein function:

Involved in endosomal sorting and trafficking of membrane proteins.

Applications:

Studies on endosomal trafficking and signal transduction.

Grin2d

|

Glutamate ionotropic receptor NMDA type subunit 2D

Synonyms:

GluN2D, NMDAR2D

Gene ID (NCBI):

14814

Protein function:

Subunit of NMDA receptors; contributes to excitatory neurotransmission and synaptic plasticity.

Applications:

Epilepsy models, neurodevelopmental studies

Gstt1

|

Glutathione S-transferase theta 1

Synonyms:

GST class-theta-1, GSTT1-1

Gene ID (NCBI):

14871

Protein function:

Enzyme involved in detoxification by conjugating glutathione to various electrophilic compounds.

Applications:

Studies on detoxification pathways and cancer susceptibility.

Hells

|

Helicase, lymphoid specific

Synonyms:

Lsh, PASG, SMARCA6

Gene ID (NCBI):

15201

Protein function:

Chromatin remodeling ATPase involved in DNA methylation and gene silencing.

Applications:

Studies on DNA methylation, chromatin remodeling, and immune function.

Hexb

|

Hexosaminidase B

Synonyms:

Beta-hexosaminidase subunit beta

Gene ID (NCBI):

15212

Protein function:

Enzyme that degrades GM2 gangliosides; deficiency leads to accumulation in lysosomes.

Applications:

Models for lysosomal storage diseases and neurodegeneration.

Gstm6

|

Glutathione S-transferase mu 6

Synonyms:

-

Gene ID (NCBI):

14867

Protein function:

Involved in detoxification processes; conjugates reduced glutathione to a variety of substrates.

Applications:

Cancer research, pharmacogenomics studies

Gsta4

|

Glutathione S-transferase alpha 4

Synonyms:

GST5.7, mGsta4

Gene ID (NCBI):

14860

Protein function:

Detoxification enzyme; catalyzes the conjugation of glutathione to toxic substances.

Applications:

Oxidative stress studies, neurodegeneration research

Grin1

|

Glutamate ionotropic receptor NMDA type subunit 1

Synonyms:

GluN1, NMDAR1

Gene ID (NCBI):

14810

Protein function:

Essential subunit of NMDA receptors; involved in synaptic plasticity and memory function.

Applications:

Neurological disease models, synaptic function studies

Grb2

|

Growth factor receptor-bound protein 2

Synonyms:

Ash, EGF receptor-binding protein GRB2

Gene ID (NCBI):

14784

Protein function:

Adapter protein linking receptor tyrosine kinases to the Ras signaling pathway; essential for cell communication.

Applications:

Cancer research, signal transduction studies

Grb7

|

Growth factor receptor-bound protein 7

Synonyms:

-

Gene ID (NCBI):

14786

Protein function:

Adapter protein involved in signal transduction; interacts with receptor tyrosine kinases.

Applications:

Cancer metastasis models, cell migration studies

Gpr33

|

G protein-coupled receptor 33

Synonyms:

-

Gene ID (NCBI):

14762

Protein function:

Orphan receptor; potential role in immune response modulation.

Applications:

Immune response studies, receptor signaling research

Eomes

|

Eomesodermin

Synonyms:

Tbr2, eomesodermin

Gene ID (NCBI):

13813

Protein function:

T-box transcription factor crucial for mesoderm formation and cytotoxic T-cell development.

Applications:

Embryogenesis, immune function

Pdpn

|

Podoplanin

Synonyms:

Aggrus, T1alpha

Gene ID (NCBI):

14726

Protein function:

Involved in cell migration and tumor metastasis; plays a role in lymphatic vessel formation.

Applications:

Cancer metastasis models, lymphangiogenesis studies

Got1

|

Glutamic-oxaloacetic transaminase 1

Synonyms:

Aspartate aminotransferase, cytoplasmic

Gene ID (NCBI):

14718

Protein function:

Catalyzes the reversible transfer of an amino group between aspartate and glutamate; key in amino acid metabolism.

Applications:

Metabolic studies, liver function research

Gnao1

|

Guanine nucleotide-binding protein G(o) subunit alpha

Synonyms:

Gna0, Gnao

Gene ID (NCBI):

14681

Protein function:

Mediates signal transduction in the nervous system; involved in neurotransmitter signaling pathways.

Applications:

Neurological disease models, signal transduction studies

Gja8

|

Gap junction protein, alpha 8

Synonyms:

Cx50, Connexin-50, Cx-50

Gene ID (NCBI):

14616

Protein function:

Lens-specific gap junction channel mediating cell-cell communication.

Applications:

Eye development, lens communication

Gclc

|

Glutamate-cysteine ligase, catalytic subunit

Synonyms:

GLCL, GSH1

Gene ID (NCBI):

14629

Protein function:

Catalytic subunit of the enzyme initiating glutathione synthesis; protects from oxidative stress.

Applications:

Glutathione metabolism, antioxidant defense

Ggt1

|

Gamma-glutamyltransferase 1

Synonyms:

GGT, CD224

Gene ID (NCBI):

14598

Protein function:

Key enzyme in glutathione metabolism; recycles amino acids and detoxifies xenobiotics.

Applications:

Antioxidant pathways, liver toxicity models

Ggps1

|

Geranylgeranyl diphosphate synthase 1

Synonyms:

GGPPS, GGPP synthase

Gene ID (NCBI):

14593

Protein function:

Catalyzes synthesis of GGPP, essential for protein prenylation and membrane attachment.

Applications:

Isoprenoid synthesis, protein targeting

Gfpt2

|

Glutamine-fructose-6-phosphate transaminase 2

Synonyms:

GFAT2, GFPT2

Gene ID (NCBI):

14584

Protein function:

Isoform of GFPT1; regulates protein glycosylation and O-GlcNAc signaling.

Applications:

Glycosylation under stress, cancer metabolism

Gfap

|

Glial fibrillary acidic protein

Synonyms:

Glial fibrillary acidic protein

Gene ID (NCBI):

14580

Protein function:

Astrocyte-specific intermediate filament protein essential for CNS integrity.

Applications:

Glial biology, CNS injury models

Usp15

|

Ubiquitin specific peptidase 15

Synonyms:

Gcap18, UNPH-2, UNPH4

Gene ID (NCBI):

14479

Protein function:

Deubiquitinating enzyme involved in TGF-β signaling, spliceosome stability, and NF-κB regulation.

Applications:

TGF-β signaling, splicing, inflammation

Gfpt1

|

Glutamine-fructose-6-phosphate transaminase 1

Synonyms:

GFA, GFAT1, Gfat

Gene ID (NCBI):

14583

Protein function:

Catalyzes rate-limiting step in hexosamine biosynthetic pathway; key for glycosylation.

Applications:

Muscle glycosylation, metabolism

Gfi1b

|

Growth factor independent 1B transcription repressor

Synonyms:

Gfi-1B

Gene ID (NCBI):

14582

Protein function:

Zinc finger transcription repressor essential for erythropoiesis and platelet development.

Applications:

Hematopoiesis, blood lineage models

Gdi2

|

GDP dissociation inhibitor 2

Synonyms:

GDI-B, GDIB, RabGDIB

Gene ID (NCBI):

14569

Protein function:

Regulates Rab GTPases by stabilizing the GDP-bound form; essential for vesicle trafficking.

Applications:

Intracellular trafficking, Rab signaling

Gad2

|

Glutamate decarboxylase 2

Synonyms:

GAD65, Glutamate decarboxylase 2

Gene ID (NCBI):

14417

Protein function:

Catalyzes conversion of glutamate to GABA in inhibitory neurons.

Applications:

GABA signaling, autoimmune diabetes

Fyn

|

FYN proto-oncogene, Src family tyrosine kinase

Synonyms:

p59fyn, SLK

Gene ID (NCBI):

14360

Protein function:

Non-receptor tyrosine kinase in TCR signaling and neural function.

Applications:

T-cell activation, synaptic signaling

Fzd3

|

Frizzled class receptor 3

Synonyms:

Frizzled homolog 3

Gene ID (NCBI):

14365

Protein function:

Wnt receptor involved in planar cell polarity and neural patterning.

Applications:

Wnt signaling, neuronal guidance

Sh3pxd2a

|

SH3 and PX domains 2A

Synonyms:

Tks5, Fish

Gene ID (NCBI):

14218

Protein function:

Scaffold protein regulating podosome formation and cell invasion.

Applications:

Invasion biology, actin remodeling

Fgf2

|

Fibroblast growth factor 2

Synonyms:

bFGF, HBGF-2

Gene ID (NCBI):

14173

Protein function:

Broad mitogen promoting cell proliferation, differentiation, and angiogenesis.

Applications:

Angiogenesis, tissue repair

Fgf10

|

Fibroblast growth factor 10

Synonyms:

Fibroblast growth factor 10, AIGF

Gene ID (NCBI):

14165

Protein function:

Stimulates epithelial cell growth and branching morphogenesis.

Applications:

Developmental biology, organogenesis

Fdx1

|

Ferredoxin 1

Synonyms:

Ferredoxin 1, Adrenodoxin

Gene ID (NCBI):

14148

Protein function:

Electron carrier in mitochondria, essential for steroidogenesis and redox reactions.

Applications:

Mitochondrial electron transport, steroidogenesis

Fbp2

|

Fructose-bisphosphatase 2

Synonyms:

Fructose-1,6-bisphosphatase 2

Gene ID (NCBI):

14120

Protein function:

Catalyzes fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis.

Applications:

Glucose metabolism, gluconeogenesis

F7

|

Coagulation factor VII

Synonyms:

Coagulation factor VII, SPCA

Gene ID (NCBI):

14068

Protein function:

Initiates coagulation via the extrinsic pathway with tissue factor.

Applications:

Coagulation cascade, bleeding disorder research

F2

|

Coagulation factor II

Synonyms:

Coagulation factor II, Prothrombin

Gene ID (NCBI):

14061

Protein function:

Precursor to thrombin, a key enzyme in blood coagulation cascade.

Applications:

Hemostasis, coagulation studies

Ezh2

|

Enhancer of zeste 2 polycomb repressive complex 2 subunit

Synonyms:

Enx1, KMT6, Lysine methyltransferase 6

Gene ID (NCBI):

14056

Protein function:

Histone methyltransferase that trimethylates H3K27 to promote gene silencing.

Applications:

Epigenetics, gene repression, PRC2

F10

|

Coagulation factor X

Synonyms:

Factor X, coagulation factor X

Gene ID (NCBI):

14058

Protein function:

Vitamin K-dependent serine protease initiating thrombin generation in coagulation cascade.

Applications:

Coagulation, bleeding disorder research

Celf2

|

CUGBP Elav-like family member 2

Synonyms:

BRUNOL4, CUG-BP2, NAPOR

Gene ID (NCBI):

14007

Protein function:

RNA-binding protein modulating alternative splicing and mRNA stability in neurons and muscle.

Applications:

Post-transcriptional gene regulation

Khdrbs3

|

KH RNA binding domain containing, signal transduction associated 3

Synonyms:

Sam68-like 3, T-star, Slm-2

Gene ID (NCBI):

13992

Protein function:

RNA-binding protein regulating alternative splicing in neurons and testis.

Applications:

RNA processing, neuronal function

Epas1

|

Endothelial PAS domain protein 1

Synonyms:

Hif-2α, HIF2A, MOP2

Gene ID (NCBI):

13819

Protein function:

Hypoxia-inducible transcription factor regulating erythropoiesis and angiogenesis.

Applications:

Hypoxia models, erythropoiesis

Ercc2

|

Excision repair cross-complementation group 2

Synonyms:

Xpd, Rad3

Gene ID (NCBI):

13871

Protein function:

DNA helicase involved in nucleotide excision repair and transcription-coupled repair.

Applications:

DNA repair, transcription-coupled repair

Elk4

|

ELK4 ETS transcription factor

Synonyms:

SAP1, ELK-1-like, Elk-4

Gene ID (NCBI):

13714

Protein function:

Transcription factor in the SRF complex regulating immediate-early gene expression.

Applications:

MAPK signaling, transcriptional regulation

Ehd1

|

EH-domain containing 1

Synonyms:

EH domain containing 1, PAST

Gene ID (NCBI):

13660

Protein function:

Involved in endocytic recycling and membrane trafficking.

Applications:

Membrane trafficking, endocytosis

Efna5

|

Ephrin A5

Synonyms:

Ephrin-A5, LERK-7, AL-1

Gene ID (NCBI):

13640

Protein function:

Ligand for Eph receptors, regulating cell positioning, axon guidance, and development.

Applications:

Brain development, angiogenesis

Dsc3

|

Desmocollin 3

Synonyms:

Desmocollin-3, Cadherin family member 3

Gene ID (NCBI):

13507

Protein function:

Calcium-dependent adhesion molecule of epithelial desmosomes.

Applications:

Skin barrier modeling, desmosome function

Dpm2

|

DPM2

Synonyms:

Dolichyl-phosphate mannosyltransferase subunit 2

Gene ID (NCBI):

13481

Protein function:

Regulatory subunit of DPM synthase complex for protein N-glycosylation.

Applications:

Protein folding, ER biology

No results

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genO-MC38-hPD‑L1-hCD47-LZ

The genO‑MC38-hPD-L1-hCD47-LZ clonal cell line expresses high levels of human PD-L1 and human CD47.

MC38

Immune checkpoint

PD-L1

CD47

genO-hCT26-hPD‑L1

The humanized hPD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumors in vivo.

PD-L1

Immune checkpoint

CT26

genO-MC38-Pd-l1KO

The Pd-l1 Knockout colon adenocarcinoma MC38 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

PD-L1

Immune checkpoint

genO-CT26-Pd-l1KO

The Pd-l1 Knockout colon carcinoma CT26 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

Immune checkpoint

PD-L1

CT26

genO-CT26-hCD39-LZ

The genO-CT26-hCD39-LZ clonal cell line expresses high levels of human/mouse chimeric CD39, and forms solid tumors in vivo.

CT26

Immune checkpoint

CD39

genO-CT26-hEpCAM-LZ

genO-CT26-hEpCAM-LZ clonal cell line expresses high levels of human EpCAM, and forms solid tumors in vivo.

CT26

Immune checkpoint

EpCAM

genO-EL4-hCD19-LZ

genO-EL4-hCD19-LZ cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

CD19

EL4

Immune checkpoint

genO-EL4-hCD20-LZ

The genO-EL4-hCD20-LZ clonal cell line expresses high levels of human CD20.

CD20

Immune checkpoint

EL4

genO-MC38-hCD39-LZ

The genO-MC38-hCD39-LZ cells homogeneously express human CD39 in vitro, and form infiltrated tumors in immunocompetent mice.

CD39

MC38

Immune checkpoint

genO-MC38-hPD-L1-hHER2-LZ

The genO-MC38-hPD-L1-hHER2-LZ clonal cell line expresses high levels of human PD-L1 and human HER2.

MC38

Immune checkpoint

PD-L1

HER2

genO-MC38-hPD-L1-LZ

The genO-MC38-hPD-L1-LZ clonal cell line expresses high levels of human PD-L1 and forms solid tumors in vivo. An optimized version of a luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.

PD-L1

Immune checkpoint

MC38

PD-1

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Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993

Eur J Nucl Med Mol Imaging

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Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

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PLoS One

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ERα-36 regulates progesterone receptor activity in breast cancer

Breast Cancer Res

T cells expressing a chimeric-PD1-Dap10-CD3zeta receptor reduce tumor burden in multiple murine syngeneic models of solid cancer

Immunology

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Cancer Immunol Res

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Nat Immunol

iPS technology: Four factors that will change the world… some day

iPS technology

Improving in vitro models: the coming of age of organoids

Organoids

Syngeneic mouse models

Customized mouse model

Tumor grafts in preclinical research: Models, models, overall, who is the fittest of them all?

Tumor-graft models

A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway

Humanized PD-1/PD-L1 mouse and cell line

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Humanized ICP mouse and cell lines

Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized genO-hCD47/hSIRPα mouse and genO-MC38-hPD-L1-hCD47-LZ cell line

Targeting the human CD47/SIRPα axis

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