Preclinical Humanized LIGHT Mouse Model
Design of the hLIGHT mouse
The humanized LIGHT mouse model (hLIGHT) is developed by Knockin at the mouse Light locus, and expresses a chimeric LIGHT with human extracellular, human transmembrane and murine intracellular domains.
Applications in immuno-oncology
The hLIGHT mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint LIGHT in fully immunocompetent mice.
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hLIGHT features and validation
The model has been developed and currently undergoes further validation steps by our partners of the precompetitive consortium–company leaders in immuno-oncology and immunotherapy.
hLIGHT is expressed on activated splenic T cells
Expression of human LIGHT (hLIGHT) on splenic Teff and CD8 T cells activated with αCD3/αCD28 in presence of rmIL-2 for 24h.
Ready to be shipped to your lab
- Cohorts available upon request
- Studies can be carried out at your site or at your favorite CRO
- SOPF certification and worldwide delivery by professional breeders
- Models provided with FTO on patent-protected technologies used for model generation
Are you looking for another target?
Follow this link for humanized immune checkpoint (ICP) mouse models, or contact us.