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Knockout and reporter models

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

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Knockout models

Knockout models, a cornerstone in biomedical research, involve the targeted inactivation of specific genes to understand their function. By "knocking out" a gene, you can observe the resulting phenotype changes, shedding light on the gene's role in health and disease.

Platforms like the European Conditional Mouse Mutagenesis Program contribute significantly, providing a standardized approach to generating and studying Knockout mice. These models are instrumental in deciphering gene functions, offering crucial insights into molecular pathways and potential therapeutic targets.

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Reporter models

Reporter models are genetically modified with reporter genes, like fluorescent proteins, to enable real-time visualization of specific biological processes.

They serve as invaluable tools for researchers, providing dynamic insights into disease progression, treatment responses, and the effects of genetic modifications.

By observing the behavior of reporter genes in living animals, scientists gain a deeper understanding of complex biological mechanisms, making these models indispensable in advancing biomedical research.

Nup88

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Nucleoporin 88

Synonyms:
Nucleoporin 88kDa, Nup84, Prei2
Gene ID (NCBI):
19069
Protein function:
Component of the nuclear pore complex; involved in nucleocytoplasmic transport.
Applications:  
Studies on nuclear transport and gene regulation.

Mapk11

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Mitogen-activated protein kinase 11

Synonyms:
p38β, SAPK2, PRKM11
Gene ID (NCBI):
19094
Protein function:
Serine/threonine kinase involved in stress response and inflammation signaling.
Applications:  
Research on MAPK signaling pathways and inflammation.

Ppp5c

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Protein phosphatase 5 catalytic subunit

Synonyms:
Protein phosphatase 5, PP5
Gene ID (NCBI):
19060
Protein function:
Serine/threonine phosphatase involved in stress response and cell cycle regulation.
Applications:  
Research on stress signaling and cell cycle control.

Ppp3cc

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Protein phosphatase 3 catalytic subunit gamma

Synonyms:
Calcineurin A gamma, PP2B-A gamma
Gene ID (NCBI):
19057
Protein function:
Calcium/calmodulin-dependent protein phosphatase involved in T-cell activation.
Applications:  
Studies on immune signaling and T-cell activation.

Ppm1a

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Protein phosphatase 1A, magnesium-dependent, alpha isoform

Synonyms:
Protein phosphatase 1A, PP2C-alpha
Gene ID (NCBI):
19042
Protein function:
Serine/threonine phosphatase involved in stress response and cell cycle control.
Applications:  
Research on cell cycle and stress signaling pathways.

Plxna2

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Plexin A2

Synonyms:
KIAA0463, OCT
Gene ID (NCBI):
18845
Protein function:
Receptor for semaphorins; involved in axon guidance and neuronal development.
Applications:  
Studies on neural development and guidance cues.

Pa2g4

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Proliferation-associated 2G4

Synonyms:
EBP1, ErbB3-binding protein 1, p38-2G4
Gene ID (NCBI):
18813
Protein function:
Involved in cell proliferation and differentiation; interacts with ErbB3 receptor.
Applications:  
Research on cell cycle regulation and oncology.

Pla2g2c

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Phospholipase A2 group IIC

Synonyms:
UBXN10-AS1
Gene ID (NCBI):
18781
Protein function:
Enzyme involved in phospholipid metabolism; may play a role in inflammation.
Applications:  
Research on lipid metabolism and inflammation.

Prkcz

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Protein kinase C, zeta

Synonyms:
PKCζ, aPKCζ
Gene ID (NCBI):
18762
Protein function:
Atypical protein kinase C involved in signal transduction pathways.
Applications:  
Research on signal transduction and disease mechanisms.

Plau

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Plasminogen activator, urokinase

Synonyms:
Urokinase-type plasminogen activator, UPA
Gene ID (NCBI):
18792
Protein function:
Converts plasminogen to plasmin, involved in fibrinolysis and tissue remodeling.
Applications:  
Studies on cancer progression and thrombosis.

Pkig

|

Protein kinase inhibitor gamma

Synonyms:
PKIγ, cAMP-dependent protein kinase inhibitor gamma
Gene ID (NCBI):
18769
Protein function:
Inhibits cAMP-dependent protein kinase activity, regulating signal transduction pathways.
Applications:  
Studies on cAMP signaling and metabolic regulation.

Pdgfrb

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Platelet derived growth factor receptor beta polypeptide

Synonyms:
PDGFR-β
Gene ID (NCBI):
18596
Protein function:
Receptor tyrosine kinase involved in cell proliferation and development.
Applications:  
Studies on angiogenesis and tissue regeneration.

Pfn1

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Profilin 1

Synonyms:
Profilin 1, actin binding protein
Gene ID (NCBI):
18643
Protein function:
Actin-binding protein regulating cytoskeletal dynamics.
Applications:  
Research on cytoskeleton and neurodegenerative diseases.

Pde8a

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Phosphodiesterase 8A

Synonyms:
Pde8
Gene ID (NCBI):
18584
Protein function:
Enzyme hydrolyzing cAMP, regulating intracellular signaling pathways.
Applications:  
Research on signal transduction and pharmacology.

Pitx2

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Paired-like homeodomain transcription factor 2

Synonyms:
Brx1, Munc30, Rieg
Gene ID (NCBI):
18741
Protein function:
Transcription factor involved in organ development and left-right asymmetry.
Applications:  
Studies on developmental biology and congenital disorders.

Pfkl

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Phosphofructokinase, liver, B-type

Synonyms:
Pfk-liver, Pfk
Gene ID (NCBI):
18641
Protein function:
Key glycolytic enzyme converting fructose-6-phosphate to fructose-1,6-bisphosphate.
Applications:  
Studies on energy metabolism and enzymopathies.

Per2

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Period circadian clock 2

Synonyms:
Period circadian protein homolog 2
Gene ID (NCBI):
18627
Protein function:
Core component of the circadian clock regulating biological rhythms.
Applications:  
Research on chronobiology and metabolic regulation.

Pbx3

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Pre B cell leukemia homeobox 3

Synonyms:
Pre-B-cell leukemia transcription factor 3
Gene ID (NCBI):
18516
Protein function:
Transcription factor involved in developmental processes and hematopoiesis.
Applications:  
Research on developmental biology and oncology.

Pcx

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Pyruvate carboxylase

Synonyms:
Pc
Gene ID (NCBI):
18563
Protein function:
Enzyme catalyzing the carboxylation of pyruvate to oxaloacetate, key in gluconeogenesis.
Applications:  
Studies on metabolism and energy homeostasis.

Pax5

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Paired box 5

Synonyms:
EBB-1, Pax-5
Gene ID (NCBI):
18507
Protein function:
Transcription factor essential for B-cell lineage commitment and development.
Applications:  
Studies on immune system development and hematological malignancies.

P2rx7

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Purinergic receptor P2X, ligand-gated ion channel 7

Synonyms:
P2X7, P2X7R
Gene ID (NCBI):
18439
Protein function:
ATP-gated ion channel involved in inflammation and cell death.
Applications:  
Studies on immune response and neuroinflammation.

P2rx4

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Purinergic receptor P2X, ligand-gated ion channel 4

Synonyms:
P2X4
Gene ID (NCBI):
18438
Protein function:
ATP-gated ion channel involved in synaptic transmission and inflammation.
Applications:  
Research on pain mechanisms and vascular function.

P2rx6

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Purinergic receptor P2X, ligand-gated ion channel 6

Synonyms:
P2X6, P2rxl1, P2xm
Gene ID (NCBI):
18440
Protein function:
ATP-gated ion channel; forms heteromeric channels with other P2X subunits.
Applications:  
Research on nociception and vascular biology.

Pak1

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p21 (RAC1) activated kinase 1

Synonyms:
PAK-1, p21-activated kinase 1
Gene ID (NCBI):
18479
Protein function:
Serine/threonine kinase involved in cytoskeletal remodeling and cell motility.
Applications:  
Studies on cell signaling, cancer, and metabolism.

Mybbp1a

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MYB binding protein (P160) 1a

Synonyms:
P160, Myb-binding protein 1a
Gene ID (NCBI):
18432
Protein function:
Transcriptional regulator involved in ribosome biogenesis and p53 activation.
Applications:  
Studies on transcription regulation and tumorigenesis.

Slc25a15

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Solute carrier family 25 member 15

Synonyms:
Ornt1, D630044L02Rik
Gene ID (NCBI):
18408
Protein function:
Mitochondrial ornithine transporter; essential for urea cycle function.
Applications:  
Metabolic disorder models, urea cycle studies.

Nxn

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Nucleoredoxin

Synonyms:
-
Gene ID (NCBI):
18230
Protein function:
Redox-regulating protein that modulates Wnt signaling by interacting with Dishevelled proteins.
Applications:  
Research on redox biology and Wnt signaling.

Ntrk2

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Neurotrophic tyrosine kinase, receptor, type 2

Synonyms:
TrkB, Trk-B
Gene ID (NCBI):
18212
Protein function:
Receptor for BDNF and NT-4; involved in CNS development and synaptic plasticity.
Applications:  
Studies on neurodevelopment and metabolic disorders.

Emc8

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ER membrane protein complex subunit 8

Synonyms:
-
Gene ID (NCBI):
18117
Protein function:
Part of the ER membrane protein complex; assists in membrane protein insertion.
Applications:  
Research on ER function and protein biogenesis.

Ntrk1

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Neurotrophic tyrosine kinase, receptor, type 1

Synonyms:
TrkA, Trk, Tkr
Gene ID (NCBI):
18211
Protein function:
High-affinity receptor for nerve growth factor; critical for neuronal survival and differentiation.
Applications:  
Neurological disorder models, pain research.

Npc1

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NPC intracellular cholesterol transporter 1

Synonyms:
Niemann-Pick disease, type C1
Gene ID (NCBI):
18145
Protein function:
Mediates intracellular cholesterol trafficking; essential for lipid homeostasis.
Applications:  
Models for lipid storage disorders and neurodegeneration.

Nras

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Neuroblastoma RAS viral oncogene homolog

Synonyms:
N-ras, c-N-Ras
Gene ID (NCBI):
18176
Protein function:
GTPase involved in cell proliferation and differentiation via MAPK/ERK pathway.
Applications:  
Cancer research, developmental biology.

Uhrf1

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Ubiquitin-like with PHD and RING finger domains 1

Synonyms:
ICBP90, Np95
Gene ID (NCBI):
18140
Protein function:
Epigenetic regulator; links DNA methylation and histone modification.
Applications:  
Studies on epigenetic regulation and gene silencing.

Notch1

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Notch 1

Synonyms:
Notch homolog 1
Gene ID (NCBI):
18128
Protein function:
Transmembrane receptor involved in cell fate decisions.
Applications:  
Research on cell differentiation and oncogenesis.

Nodal

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Nodal growth differentiation factor

Synonyms:
-
Gene ID (NCBI):
18119
Protein function:
Secreted ligand of the TGF-beta superfamily; regulates embryonic development.
Applications:  
Studies on embryogenesis and developmental biology.

Nmt2

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N-myristoyltransferase 2

Synonyms:
-
Gene ID (NCBI):
18108
Protein function:
Catalyzes N-terminal myristoylation of proteins; important for membrane targeting.
Applications:  
Studies on protein modification and signal transduction.

Nipsnap1

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Nipsnap homolog 1

Synonyms:
-
Gene ID (NCBI):
18082
Protein function:
Involved in mitophagy and pain transmission.
Applications:  
Research on mitochondrial quality control and neuropathies.

Nfatc3

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Nuclear factor of activated T cells, cytoplasmic 3

Synonyms:
NFAT4, NFATx
Gene ID (NCBI):
18021
Protein function:
Transcription factor involved in immune response regulation.
Applications:  
Studies on T-cell activation and immune regulation.

Naga

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N-acetyl galactosaminidase, alpha

Synonyms:
Alpha-N-acetylgalactosaminidase
Gene ID (NCBI):
17939
Protein function:
Lysosomal enzyme that degrades glycoproteins and glycolipids.
Applications:  
Research on lysosomal storage disorders.

Napb

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N-ethylmaleimide sensitive fusion protein attachment protein beta

Synonyms:
Beta-soluble NSF attachment protein
Gene ID (NCBI):
17957
Protein function:
Involved in vesicle fusion and neurotransmitter release at synapses.
Applications:  
Studies on synaptic function and neurological disorders.

Ncoa3

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Nuclear receptor coactivator 3

Synonyms:
AIB1, SRC-3, RAC3, TRAM-1, pCIP, KAT13B
Gene ID (NCBI):
17979
Protein function:
Coactivator for nuclear receptors; enhances transcriptional activation.
Applications:  
Studies on hormone-dependent cancers and gene regulation.

Ncf2

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Neutrophil cytosolic factor 2

Synonyms:
NOXA2, p67phox
Gene ID (NCBI):
17970
Protein function:
Component of NADPH oxidase complex; generates reactive oxygen species in immune response.
Applications:  
Models for studying immune deficiencies and oxidative stress.

Nedd4

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Neural precursor cell expressed, developmentally down-regulated 4

Synonyms:
Nedd4-1, Nedd4a, E430025J12Rik
Gene ID (NCBI):
17999
Protein function:
E3 ubiquitin-protein ligase; regulates protein degradation.
Applications:  
Research on protein ubiquitination and neuronal development.

Myo7a

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Myosin VIIA

Synonyms:
Usher syndrome type 1B protein
Gene ID (NCBI):
17921
Protein function:
Unconventional myosin involved in sensory functions, including hearing and vision.
Applications:  
Studies on sensory organ development and function.

Myl4

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Myosin, light polypeptide 4

Synonyms:
ALC-1, ELC, ELC1a, GT1, AMLC
Gene ID (NCBI):
17896
Protein function:
Light chain of myosin involved in muscle contraction, especially in atrial muscle.
Applications:  
Research on cardiac muscle function and arrhythmias.

Myh9

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Myosin, heavy polypeptide 9, non-muscle

Synonyms:
NMHC-IIA, NMMHC-IIA
Gene ID (NCBI):
17886
Protein function:
Non-muscle myosin involved in cell motility, adhesion, and cytokinesis.
Applications:  
Studies on cytoskeletal dynamics and related diseases.

Myd88

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Myeloid differentiation primary response gene 88

Synonyms:
-
Gene ID (NCBI):
17874
Protein function:
Adapter protein in Toll-like and IL-1 receptor signaling pathways; crucial for innate immunity.
Applications:  
Research on innate immune signaling and inflammation.

Myl2

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Myosin, light polypeptide 2, regulatory, cardiac, slow

Synonyms:
RLC-2, MLC-2v
Gene ID (NCBI):
17906
Protein function:
Regulatory light chain of myosin in cardiac muscle; modulates contraction.
Applications:  
Models for heart development and cardiomyopathy.

Mybpc3

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Myosin binding protein C, cardiac

Synonyms:
cMyBP-C
Gene ID (NCBI):
17868
Protein function:
Structural protein in cardiac sarcomere; regulates cardiac muscle contraction.
Applications:  
Models for cardiomyopathy and heart disease.

Mx1

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MX dynamin-like GTPase 1

Synonyms:
Mx, Mx-1
Gene ID (NCBI):
17857
Protein function:
Interferon-induced GTPase with antiviral activity against influenza and other viruses.
Applications:  
Studies on innate immunity and antiviral responses.

Msh5

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MutS homolog 5

Synonyms:
G7, MutS homolog 5
Gene ID (NCBI):
17687
Protein function:
DNA mismatch repair protein involved in meiotic recombination and genomic stability.
Applications:  
Studies on DNA repair and meiosis.

Cxcl9

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C-X-C motif chemokine ligand 9

Synonyms:
MIG, CMK, SCYB9, CRG-10
Gene ID (NCBI):
17329
Protein function:
Chemokine induced by interferon-gamma; involved in T-cell trafficking and immune responses.
Applications:  
Research on chemokine signaling and immune cell migration.

Mmp16

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Matrix metallopeptidase 16

Synonyms:
MT3-MMP
Gene ID (NCBI):
17389
Protein function:
Membrane-type metalloproteinase involved in activation of other MMPs and extracellular matrix degradation.
Applications:  
Research on extracellular matrix dynamics and cancer.

Mmp12

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Matrix metallopeptidase 12

Synonyms:
MME, ME, Macrophage elastase
Gene ID (NCBI):
17381
Protein function:
Metalloproteinase involved in extracellular matrix remodeling and tissue repair.
Applications:  
Studies on tissue remodeling and inflammatory diseases.

Mapkapk5

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Mitogen-activated protein kinase-activated protein kinase 5

Synonyms:
MK5, PRAK, MAPKAP-K5
Gene ID (NCBI):
17165
Protein function:
Serine/threonine kinase activated by p38 MAPK; involved in cell differentiation and apoptosis.
Applications:  
Studies on cell cycle regulation and apoptosis.

Marco

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Macrophage receptor with collagenous structure

Synonyms:
SCARA2, SR-A6
Gene ID (NCBI):
17167
Protein function:
Scavenger receptor involved in innate immunity and binding of bacterial pathogens.
Applications:  
Research on innate immunity and pathogen recognition.

Mgat1

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Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase

Synonyms:
GLCNAC-TI, GLCT1, GLYT1
Gene ID (NCBI):
17308
Protein function:
Enzyme involved in N-glycan biosynthesis; initiates complex N-linked carbohydrate formation.
Applications:  
Studies on glycosylation and protein processing.

Mapkapk2

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Mitogen-activated protein kinase-activated protein kinase 2

Synonyms:
MK2, MAPKAP-K2
Gene ID (NCBI):
17164
Protein function:
Serine/threonine kinase activated by p38 MAPK; involved in stress and inflammatory responses.
Applications:  
Research on inflammation and stress signaling pathways.

Lyn

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LYN proto-oncogene, Src family tyrosine kinase

Synonyms:
p53Lyn, p56Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Gene ID (NCBI):
17096
Protein function:
Non-receptor tyrosine kinase involved in B-cell receptor signaling and regulation of immune responses.
Applications:  
Studies on immune signaling and autoimmune disorders.

Cep250

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Centrosomal protein 250

Synonyms:
C-Nap1
Gene ID (NCBI):
16328
Protein function:
Component of the centrosome involved in centrosome cohesion during interphase.
Applications:  
Studies on cell division and sensory disorders.

Lrrc23

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Leucine rich repeat containing 23

Synonyms:
LRPB7, Leucine-rich repeat-containing protein 23
Gene ID (NCBI):
16977
Protein function:
Predicted to be involved in sperm motility and radial spoke assembly; contains leucine-rich repeats.
Applications:  
Studies on reproductive biology and ciliary function.

Lrmp

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Lymphoid-restricted membrane protein

Synonyms:
IRAG2, JAW1, Lymphoid-restricted membrane protein
Gene ID (NCBI):
16970
Protein function:
Involved in calcium signaling and immune cell function; interacts with inositol 1,4,5-trisphosphate receptors.
Applications:  
Research on lymphocyte signaling and immune responses.

Lmnb1

|

Lamin B1

Synonyms:
Lamin B1
Gene ID (NCBI):
16906
Protein function:
Structural component of the nuclear lamina; maintains nuclear integrity and regulates gene expression.
Applications:  
Studies on nuclear architecture and neurodegenerative diseases.

Lifr

|

Leukemia inhibitory factor receptor

Synonyms:
LIF receptor subunit alpha, CD118
Gene ID (NCBI):
16880
Protein function:
Receptor for leukemia inhibitory factor; involved in cell differentiation, survival, and proliferation.
Applications:  
Research on cytokine signaling and developmental biology.

Lepr

|

Leptin receptor

Synonyms:
LEP-R, OB-R, CD295, LEPRD, DB
Gene ID (NCBI):
16847
Protein function:
Receptor for leptin; regulates body weight, energy expenditure, and neuroendocrine function.
Applications:  
Studies on obesity, metabolism, and endocrine function.

Ldlr

|

Low density lipoprotein receptor

Synonyms:
Low-density lipoprotein receptor, Hlb301
Gene ID (NCBI):
16835
Protein function:
Mediates endocytosis of cholesterol-rich LDL particles; crucial for cholesterol homeostasis.
Applications:  
Research on lipid metabolism and cardiovascular diseases.

Ldha

|

Lactate dehydrogenase A

Synonyms:
Ldh1, Ldhm, L7R2
Gene ID (NCBI):
16828
Protein function:
Catalyzes conversion of pyruvate to lactate during anaerobic glycolysis; important in muscle metabolism.
Applications:  
Studies on energy metabolism and cancer.

Lama1

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Laminin subunit alpha-1

Synonyms:
Laminin A chain, Laminin-1 subunit alpha, S-LAM alpha
Gene ID (NCBI):
16772
Protein function:
Major component of basement membranes; involved in cell adhesion, differentiation, and migration.
Applications:  
Studies on extracellular matrix and developmental biology.

Lbp

|

Lipopolysaccharide binding protein

Synonyms:
Lipopolysaccharide-binding protein, Bpifd2
Gene ID (NCBI):
16803
Protein function:
Binds bacterial lipopolysaccharides (LPS) and transfers them to CD14 and TLR4, initiating immune responses.
Applications:  
Research on innate immunity and sepsis models.

Klkb1

|

Kallikrein B, plasma 1

Synonyms:
Plasma kallikrein
Gene ID (NCBI):
16621
Protein function:
Serine protease involved in the kallikrein-kinin system, affecting blood pressure and inflammation.
Applications:  
Research on coagulation and inflammatory pathways.

Sspn

|

Sarcospan

Synonyms:
Sarcospan
Gene ID (NCBI):
16651
Protein function:
Component of the dystrophin-glycoprotein complex, contributing to muscle membrane stability.
Applications:  
Studies on muscle integrity and dystrophin complex.

Aff3

|

AF4/FMR2 family member 3

Synonyms:
LAF4
Gene ID (NCBI):
16764
Protein function:
Transcriptional activator involved in lymphoid development and gene regulation.
Applications:  
Research on transcriptional regulation and lymphoid development.

Kif3b

|

Kinesin family member 3B

Synonyms:
-
Gene ID (NCBI):
16569
Protein function:
Component of the kinesin-II complex involved in intraflagellar transport and cilia function.
Applications:  
Studies on cilia function and embryonic development.

Kcnj12

|

Potassium inwardly-rectifying channel, subfamily J, member 12

Synonyms:
Kir2.2
Gene ID (NCBI):
16515
Protein function:
Inward rectifier potassium channel contributing to cardiac and skeletal muscle excitability.
Applications:  
Research on cardiac electrophysiology and muscle function.

Kif13b

|

Kinesin family member 13B

Synonyms:
GAKIN
Gene ID (NCBI):
16554
Protein function:
Microtubule-based motor protein involved in intracellular transport and myelination.
Applications:  
Research on axonal transport and myelination.

Kcnj9

|

Potassium inwardly-rectifying channel, subfamily J, member 9

Synonyms:
Kir3.3
Gene ID (NCBI):
16524
Protein function:
G protein-activated inward rectifier potassium channel involved in regulating neuronal excitability.
Applications:  
Studies on G protein signaling and neuronal function.

Kcnj11

|

Potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:
Kir6.2
Gene ID (NCBI):
16514
Protein function:
Forms ATP-sensitive potassium channels regulating insulin secretion in pancreatic beta cells.
Applications:  
Studies on insulin secretion and diabetes.

Kcnb1

|

Potassium voltage-gated channel subfamily B member 1

Synonyms:
Kv2.1
Gene ID (NCBI):
16500
Protein function:
Delayed rectifier potassium channel involved in action potential repolarization in neurons.
Applications:  
Research on neuronal excitability and epilepsy.

Itgae

|

Integrin alpha E

Synonyms:
CD103
Gene ID (NCBI):
16407
Protein function:
Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.
Applications:  
Studies on mucosal immunity and T-cell localization.

Itga2

|

Integrin subunit alpha 2

Synonyms:
Integrin alpha-2, CD49b
Gene ID (NCBI):
16398
Protein function:
Integrin alpha chain involved in cell adhesion and recognition in a variety of processes including embryogenesis and hemostasis.
Applications:  
Research on cell adhesion and hemostasis.

Il15

|

Interleukin 15

Synonyms:
IL-15
Gene ID (NCBI):
16168
Protein function:
Cytokine that stimulates the proliferation of T lymphocytes and is involved in the development of NK cells.
Applications:  
Research on immune cell development and cytokine therapy.

Itch

|

Itchy homolog (mouse)

Synonyms:
Itchy E3 ubiquitin protein ligase
Gene ID (NCBI):
16396
Protein function:
E3 ubiquitin ligase involved in the regulation of immune responses and protein degradation.
Applications:  
Studies on protein ubiquitination and immune regulation.

Irf1

|

Interferon regulatory factor 1

Synonyms:
IRF-1
Gene ID (NCBI):
16362
Protein function:
Transcription factor that regulates the expression of interferons and other genes involved in immune responses.
Applications:  
Research on immune regulation and transcriptional control.

Irak1

|

Interleukin-1 receptor-associated kinase 1

Synonyms:
IRAK-1
Gene ID (NCBI):
16179
Protein function:
Kinase involved in the Toll-like receptor and IL-1 receptor signaling pathways, leading to NF-κB activation.
Applications:  
Studies on innate immunity and inflammatory signaling.

Lrig1

|

Leucine-rich repeats and immunoglobulin-like domains 1

Synonyms:
LRIG1
Gene ID (NCBI):
16206
Protein function:
Transmembrane protein that negatively regulates receptor tyrosine kinases, involved in stem cell maintenance.
Applications:  
Research on stem cell biology and cancer.

Id2

|

Inhibitor of DNA Binding 2

Synonyms:
-
Gene ID (NCBI):
15902
Protein function:
Transcriptional regulator that inhibits DNA binding of basic helix-loop-helix proteins.
Applications:  
Immune system and developmental studies

Ido1

|

Indoleamine 2,3-Dioxygenase 1

Synonyms:
-
Gene ID (NCBI):
15930
Protein function:
Catalyzes the first step in tryptophan catabolism; modulates immune response.
Applications:  
Immunotherapy and metabolic studies

Il12a

|

Interleukin 12a

Synonyms:
IL-12p35
Gene ID (NCBI):
16159
Protein function:
Subunit of the cytokine IL-12, involved in the differentiation of naive T cells into Th1 cells.
Applications:  
Research on immune responses and cytokine signaling.

Il13ra2

|

Interleukin 13 receptor, alpha 2

Synonyms:
IL-13Rα2
Gene ID (NCBI):
16165
Protein function:
High-affinity receptor for IL-13, acts as a decoy receptor modulating IL-13 activity.
Applications:  
Studies on cytokine signaling and immune regulation.

Ikbkb

|

Inhibitor of kappaB kinase beta

Synonyms:
IKKβ, IKK2
Gene ID (NCBI):
16150
Protein function:
Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.
Applications:  
Studies on NF-κB signaling, inflammation, and immune responses.

Ifnar1

|

Interferon Alpha and Beta Receptor Subunit 1

Synonyms:
Ifar, Ifrc
Gene ID (NCBI):
15975
Protein function:
Part of the receptor for type I interferons; mediates antiviral responses.
Applications:  
Viral infection and immune response studies

Ide

|

Insulin Degrading Enzyme

Synonyms:
-
Gene ID (NCBI):
15925
Protein function:
Degrades insulin and other peptides; involved in glucose metabolism.
Applications:  
Metabolic and neurodegenerative disease models

Prmt1

|

Protein Arginine Methyltransferase 1

Synonyms:
Hrmt1l2
Gene ID (NCBI):
15469
Protein function:
Major type I arginine methyltransferase; modifies histones and other proteins.
Applications:  
Gene expression and developmental studies

Trmt2a

|

tRNA Methyltransferase 2 Homolog A

Synonyms:
-
Gene ID (NCBI):
15547
Protein function:
Methylates uridine residues in tRNA; involved in RNA processing.
Applications:  
RNA modification and processing studies

Prmt2

|

Protein Arginine Methyltransferase 2

Synonyms:
Hrmt1l1
Gene ID (NCBI):
15468
Protein function:
Enzyme that methylates arginine residues on histones and other proteins.
Applications:  
Epigenetic regulation and developmental studies

Hprt

|

Hypoxanthine Phosphoribosyltransferase 1

Synonyms:
Hprt1
Gene ID (NCBI):
15452
Protein function:
Enzyme in purine salvage pathway; converts hypoxanthine to IMP.
Applications:  
Purine metabolism and neurological disorder models

Hp1bp3

|

Heterochromatin Protein 1 Binding Protein 3

Synonyms:
Hp1bp74
Gene ID (NCBI):
15441
Protein function:
Chromatin-binding protein involved in gene expression regulation.
Applications:  
Epigenetics and gene expression studies

Hira

|

Histone cell cycle regulator

Synonyms:
DiGeorge syndrome critical region gene 1
Gene ID (NCBI):
15260
Protein function:
Histone chaperone involved in nucleosome assembly and chromatin remodeling.
Applications:  
Research on chromatin assembly and developmental biology.

Hoxa2

|

Homeobox A2

Synonyms:
Hox-1.11, Hox1a
Gene ID (NCBI):
15399
Protein function:
Transcription factor involved in craniofacial and skeletal development.
Applications:  
Craniofacial development studies

Hmox2

|

Heme oxygenase 2

Synonyms:
HO-2, HO2
Gene ID (NCBI):
15369
Protein function:
Enzyme that degrades heme to biliverdin, carbon monoxide, and free iron.
Applications:  
Studies on oxidative stress and neuroprotection.
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genO‑HSA/hFcRn-RAG1KO

This upgraded, immunocompromised RAG1-/- version of our genO-HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

HSA
PK/PD
Fc receptor
KO-Rep-Mix

IL-4-IRES-eGFP

The reliable monitoring and sorting of IL-4-secreting cells allows you to efficiently delineate the immune response polarization toward the Th2 pathway.

IL-4
KO-Rep-Mix

genO-Btk rat

genO-Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

BTK
Immunodeficient
KO-Rep-Mix

genO-GFP rat

The genO-GFP rat is suitable for organ & tissue transplantations and used in many biomedical fields (development, toxicology, orthotopic transplantation).

GFP
KO-Rep-Mix

KO repository

>2000 conditional Knockout mouse models for target discovery and  confirmation, in vivo compound specificity, MOA, and clinical studies

Eucomm
KO-Rep-Mix

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Adult-type granulosa cell tumor (AGCT)

castration-resistant metastatic prostate cancer (mCRPC)

CCR8

Chemokine

SIRPα

sirp-alpha

CD137

pulmonary embolism (PE)

osteomyelitis

hyperalgesia

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Myopia

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Tumor microenvironment

primary immunodeficiency (PID)

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lymphatic system

learning

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exercise

bone research

embryonic development

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von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

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Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway

Nat Commun

May 2025
Evolutionary fingerprints of epithelial-to-mesenchymal transition

Nature

Mar 2025
Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits

Brain

Feb 2025
EBP1 potentiates amyloid β pathology by regulating γ-secretase

Nat Aging

Jan 2025
GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Sci Rep

Nov 2024
NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

Nov 2024
PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Biomaterials

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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

Geroscience

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Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

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Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

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Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

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Fitusiran reduces bleeding in Factor X-deficient mice

Blood

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Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia

Neurobiol Dis

Mar 2024
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

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Mar 2024
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

Cell Death Dis

Jan 2024
Detecting Central Auditory Processing Disorders in Awake Mice

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Dec 2023
Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

Heliyon

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PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

Autophagy

Aug 2023
The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

Cancer Res

Jul 2023
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

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Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

PLoS One

Jun 2023
Brain-derived Estrogen: A Critical Player in Maintaining Cognitive Health of Aged Female Rats, Possibly Involving GPR30

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Sympathetic tone dictates the impact of lipolysis on FABP4 secretion

J Lipid Res

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Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion

JCI Insight

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Multilineage commitment of Sca-1+ cells in reshaping vein grafts

Theranostics

Apr 2023
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nat Commun

Apr 2023
Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning

Int J Mol Sci

Mar 2023
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

iScience

Mar 2023
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

Life Sci Alliance

Mar 2023
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Nat Commun

Mar 2023
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

Glia

Dec 2022
Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

FASEB J

Nov 2022
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Cell Metab

Nov 2022
Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features

Am J Respir Cell Mol Biol

Nov 2022
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH

Biochim Biophys Acta Mol Basis Dis

Sep 2022
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Nat Commun

Sep 2022
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection

Sci Rep

Sep 2022
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

Acta Neuropathol

Jul 2022
ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

Biol Trace Elem Res

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Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Prog Neurobiol

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A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Nat Metab

May 2022
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Res

May 2022
Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity

iScience

Apr 2022
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

PLoS One

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DLL3 regulates Notch signaling in small cell lung cancer

iScience

Apr 2022
Apelin controls emotional behavior in age- and metabolic state-dependent manner

Psychoneuroendocrinology

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JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

Cell Rep

Feb 2022
Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice

Mol Psychiatry

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Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall

Cell Rep

Jan 2022
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System

Int J Mol Sci

Dec 2021
Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain

Brain

Dec 2021
Characterization of Poldip2 knockout mice: avoiding incorrect gene targeting

PLoS One

Nov 2021
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

Nat Commun

Nov 2021
Highlighted article
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Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions

J Cardiovasc Pharmacol

Nov 2021
Cathepsin S Evokes PAR (2)-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models

Cancers (Basel)

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Implication of folate deficiency in CYP2U1 loss of function

J Exp Med

Sep 2021
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist

Proc Natl Acad Sci U S A

Aug 2021
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease

Matrix Biol

Aug 2021
Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse

Biochem Biophys Rep

Jul 2021
IL23R on myeloid cells is involved in murine pulmonary granuloma formation

Exp Lung Res

Jul 2021
Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis

PLoS One

Jun 2021
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract

Cardiovasc Res

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Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32

Cell Mol Immunol

May 2021
Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model

Plast Reconstr Surg

May 2021
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity

Sci Transl Med

May 2021
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration

JCI Insight

May 2021
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Cell

Apr 2021
Highlighted article
read the comment
A methionine-Mettl3-N 6-methyladenosine axis promotes polycystic kidney disease

Cell Metab

Apr 2021
Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope

FEBS J

Mar 2021
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair

J Biol Chem

Mar 2021
Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Proc Natl Acad Sci U S A

Mar 2021
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice

Proc Natl Acad Sci U S A

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Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Commun Biol

Mar 2021
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Sci Signal

Mar 2021
ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity

J Invest Dermatol

Feb 2021
Novel compounds with dual S1P receptor agonist and histamine H 3 receptor antagonist activities act protective in a mouse model of multiple sclerosis

Neuropharmacology

Jan 2021
AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice

Cereb Cortex

Jan 2021
Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

J Am Heart Assoc

Dec 2020
Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury

J Neurosci

Dec 2020
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2

J Neurosci

Nov 2020
Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response

Nat Immunol

Oct 2020
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Cell Metab

Oct 2020
Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model

Glia

Sep 2020
Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T cell responses to acute and chronic viral infection

Eur J Immunol

Jul 2020
Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration

Dev Cell

Jul 2020
Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease

Cell Death Dis

Jun 2020
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation

Nat Commun

May 2020
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Mucosal Immunol

May 2020
Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/− Mice

Int J Mol Sci

May 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation

Clin Exp Immunol

Apr 2020
The Non-Receptor Tyrosine Kinase Pyk2 Modulates Acute Locomotor Effects of Cocaine in D1 Receptor-Expressing Neurons of the Nucleus Accumbens

Sci Rep

Apr 2020
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

Immunity

Mar 2020
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma

Nucleic Acids Res

Feb 2020
HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis

Cell Rep

Feb 2020
Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

Nat Neurosci

Jan 2020
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Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Cell

Dec 2019
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Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control

Proc Natl Acad Sci U S A

Oct 2019
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Nat Metab

Oct 2019
A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

Cell Rep

Sep 2019
6 good reasons to employ our repository Knockout mouse models in your in vivo studies

Eucomm conditional Knockouts

6 min read
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Aug 2019
A Knockin C3-reporter mouse model represents a valuable tool to monitor C3 levels, a biomarker of inflamed versus uninflamed tissues

Customized mouse model

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Apr 2020
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