Other Mouse & Rat Catalog Models
PK:PD Mouse Models
- Double humanization for neonatal Fc receptor and albumin
- Measure and optimize albumin-linked small molecules and conventional drug pharmacokinetics
- Study and predict the half-life of circulating biologics and biosimilar drugs
Repository of Conditional Knockout Mice
More than 2000 ready-to-use Knockouts for:
- Disease studies
- Target discovery and confirmation
- In vivo compound specificity
- Mechanism of action (MOA) studies
Reporter Mouse Models
- Reporter model to monitor immune response polarization
- Monitor and sort IL-4-secreting cells
- Reporter model to monitor regulatory T cell activity
- Monitor and sort Foxp3-expressing cells
- Study immune tolerance and checkpoint inhibition
- Enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR
- Efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs
Rat Models
- Useful for many biomedical fields including development, toxicology and orthotopic transplantation
- Generate various eGFP rat cell lines from organs to be used for multiple purposes
- Study B-cell malignancies (e.g., diffuse large B-cell lymphoma, chronic lymphocytic leukemia)
- Assess autoimmune diseases with aberrant B cell responses (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- Screen novel Btk inhibitors for treatment of several hematologic cancers and autoimmune diseases
- Study lymphoid compartment development, B-cell malignancies (e.g., leukemias, lymphomas), xenografts, inflammatory disorders, infectious diseases
- Cohorts available upon request
- Studies can be carried out at your site or at your favorite CRO
- SOPF certification and worldwide delivery by professional breeders
- Models provided with FTO on patent-protected technologies used for model generation