Other Mouse & Rat Catalog Models

Humanized Mouse Catalog

PK:PD Mouse Models

HSA/hFcRn

  • Double humanization for neonatal Fc receptor and albumin
  • Measure and optimize albumin-linked small molecules and conventional drug pharmacokinetics
  • Study and predict the half-life of circulating biologics and biosimilar drugs

 

Repository of Conditional Knockout Mice

More than 2000 ready-to-use Knockouts for:

  • Disease studies
  • Target discovery and confirmation
  • In vivo compound specificity
  • Mechanism of action (MOA) studies

 

Reporter Mouse Models

IL-4-IRES-eGFP (4get)

  • Reporter model to monitor immune response polarization
  • Monitor and sort IL-4-secreting cells

Foxp3-IRES-mRFP (FIR)

  • Reporter model to monitor regulatory T cell activity
  • Monitor and sort Foxp3-expressing cells
  • Study immune tolerance and checkpoint inhibition

hGITR/Foxp3

  • Enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR
  • Efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs

 

Rat Models

GFP reporter

  • Useful for many biomedical fields including development, toxicology and orthotopic transplantation
  • Generate various eGFP rat cell lines from organs to be used for multiple purposes

Btk Knockout

  • Study B-cell malignancies (e.g., diffuse large B-cell lymphoma, chronic lymphocytic leukemia)
  • Assess autoimmune diseases with aberrant B cell responses (e.g., rheumatoid arthritis, systemic lupus erythematosus)
  • Screen novel Btk inhibitors for treatment of several hematologic cancers and autoimmune diseases

Immunodeficient SDRG

  • Study lymphoid compartment development, B-cell malignancies (e.g., leukemias, lymphomas), xenografts, inflammatory disorders, infectious diseases

 

  • Cohorts available upon request
  • Studies can be carried out at your site or at your favorite CRO
  • SOPF certification and worldwide delivery by professional breeders
  • Models provided with FTO on patent-protected technologies used for model generation