Other Catalog Models

Humanized Mouse Catalog

Humanized Mouse Models to Study Inflammation & Allergy

hCD4

  • In vivo efficacy and safety assessment of anti-human CD4 compounds
  • Typically used in the fields of inflammation, autoimmune diseases, immuno-oncology, and HIV infection

hIgE + FcεR1

  • Double humanization for IgE and Fcε receptor 1
  • Screen for innovative therapeutics for allergy, asthma, and other IgE-mediated diseases

hTNF-α

  • In vivo efficacy and safety assessment of anti-human TNF-α compounds in the field of autoimmune diseases and inflammation

 

Reporter Mouse Models

IL-4-IRES-eGFP (4get)

  • Reporter model to monitor immune response polarization
  • Monitor and sort IL-4-secreting cells

Foxp3-IRES-mRFP (FIR)

  • Reporter model to monitor regulatory T cell activity
  • Monitor and sort Foxp3-expressing cells
  • Study immune tolerance and checkpoint inhibition

hGITR/Foxp3

  • Enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR
  • Efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs

 

PK/PD Mouse Models

hFcRn + hAlbumin

  • Double humanization for neonatal Fc receptor and albumin
  • Measure and optimize albumin-linked small molecules and conventional drug pharmacokinetics
  • Study and predict the half-life of circulating biologics and biosimilar drugs

 

Rat Models

GFP

  • Useful for many biomedical fields including development, toxicology and orthotopic transplantation
  • Generate various eGFP rat cell lines from organs to be used for multiple purposes

 

  • Cohorts available upon request
  • Studies can be carried out at your site or at your favorite CRO
  • VAF Elite/SOPF certification and worldwide delivery by professional breeders
  • Models provided with FTO on patent-protected technologies used for model generation