（Maxivax）遺伝子改変カプセル化細胞による低用量抗CTLA-4抗体の持続的送達が、大腸がんモデルにおいて腫瘍反応を誘導し、生存期間を延長する

要旨

Systemic therapy with CTLA-4 blocking antibody (aCTLA4) restores endogenous anti tumor immunity and induces remarkable long-term clinical benefits in patients with melanoma. Yet immune-related side effects remain a major hurdle to extend its label to many more types of cancer. Intra- and peritumoral administration of aCTLA4 has recently emerged to optimize its dose/efficacy ratio while preventing its on-target, off-tumor systemic toxicities. Sustained delivery of low dose aCTLA4 by genetically engineered encapsulated cells (MVX-3) could offer a promising option for cancer treatment addressing the shortcomings of systemic therapy.

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