Single-Targeted Humanized Immune Checkpoint (ICP) Mouse Models
These models are suitable to assess the efficacy of immuno-oncology compounds targeting immune checkpoints in fully immunocompetent mice.
- Cohorts available upon request
- Studies can be carried out at your site or at your favorite CRO
- SOPF certification and worldwide delivery by professional breeders
- Models provided with FTO on patent-protected technologies used for model generation
Single-targeted ICP mouse models
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Target: PD‑1 The humanized PD-1 mouse model (hPD-1) expresses human PD-1 instead of murine PD-1 while the regulation of PD-1 expression is kept under the mouse promoter. The anti-tumor effect induced by anti-hPD-1 antibody pembrolizumab is shown using our model. |
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Target: CTLA-4 The human CTLA-4 expression recapitulates the mouse CTLA-4 expression on T cells. An anti-tumor response, induced by anti-hCTLA-4 ipilimumab, is observed in hCTLA-4-expressing mice. |
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Target: VISTA The human VISTA expression pattern in homozygous mice is similar to murine VISTA in wild-type mice. Moreover, the model has been shown to be functional in vivo, because the combination of anti-hVISTA and anti-mPD-1 therapies increases survival in a MC38 tumor model. |
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Target: OX40 The human OX40 expression mirrors the murine OX40 expression. hOX40 is functional and hOX40L induces increased T-cell proliferation in vitro. Furthermore, anti-tumor effect induced by an anti-hOX40 antibody (BMS 986178 analog) was observed in a MC38 tumor model. |
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Target: GITR hGITR is detected on activated splenocytes and tumor-infiltrating lymphocytes (TILs). The model is functional as it has been used to show the anti-tumor effect of an anti-hGITR antibody. |
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Target: LIGHT The human LIGHT expression mirrors the murine LIGHT expression. hLIGHT is functional and its stimulation increases T-cell activation in vivo. |
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Target: CD28 The human CD28 expression recapitulates murine CD28 expression. hCD28 is functional: α-human CD28 co-stimulation induces T cell activation and proliferation. |
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Target: CD39 The human CD39 expression recapitulates murine CD39 expression. hCD39 is functional: α-human CD39 specifically reduces human CD39 activity. |
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Target: STING The humanized STING model, developed by Knockin at the mouse STING locus, expresses a full human STING. hSTING is functional: Agonists induce cytokine release in vivo. |