Applications of the genO‑panhCD3/hPD-1 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, immuno-inflammation and autoimmunity:
- 以下のような多様な化合物の有効性を評価する:
- T-cell engagers targeting both hCD3 and hPD-1
- Therapeutics targeting hPD-1, such as bispecific antibodies and immune checkpoint inhibitors
- Evaluate the safety of therapeutics, such as inducing cytokine release syndrome (CRS) via treatment with hCD3-targeting antibodies
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
特長
- Physiological expression of human CD3 and human PD-1
- 機能的なCD3/TCR相互作用
- 機能的なT細胞とB細胞の協調作用
- 完全に機能し、恒常性が保たれたマウスの免疫系
- マウス標的遺伝子の発現欠如
ガイド:T細胞エンゲージャーの有効性および安全性試験におけるCD3マウスモデルの比較。 ガイドを読む →
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