Double-Targeted Immune Checkpoint (ICP) Mouse Models

Humanized Immune Checkpoint Mouse Models

The double-targeted immune checkpoint mice are generated from intercrossing our single-targeted models. They enable the in vivo efficacy assessment and profiling of immuno-oncology agents in fully immunocompetent mice.

  • Cohorts available upon request
  • Studies can be carried out at your site or at your favorite CRO
  • VAF Elite/SOPF certification and worldwide delivery by professional breeders
  • Models provided with FTO on patent-protected technologies used for model generation

Double-targeted ICP mouse models

If you are looking for other targets, get in touch with us.

hPD-1-hTIM3

Target: PD‑1 & TIM3                    

The double-humanized PD-1/TIML3 mouse model (hPD-1/hTIM3) expresses human PD-1 and human TIM3 instead of murine proteins while its regulation is kept under the mouse promoter. This model was generated by intercrossing hPD-1 and hTIM3 mice. Learn more


hPD-1-hVISTA

Target: PD‑1 & VISTA                    

The double-humanized PD-1/VISTA mouse model (hPD-1/hVISTA) expresses human PD-1 and VISTA instead of murine proteins while its regulation is kept under the mouse promoter. This model was generated by intercrossing hPD-1 and hVISTA mice. Learn more


hPD-1-hCTLA-4

Target: PD‑1 & CTLA-4                    

The double-humanized PD-1/CTLA-4 mouse model (hPD-1/hCTLA-4) expresses human PD-1 and CTLA-4 instead of murine proteins while its regulation is kept under the mouse promoter. This model was generated by intercrossing hPD-1 and hCTLA-4 miceLearn more


hCTLA-4-LAG3

Target: CTLA-4 & LAG3                    

The double-humanized CTLA-4/LAG3 mouse model (hCTLA-4/hLAG3) expresses human CTLA-4 and LAG3 instead of murine proteins while its regulation is kept under the mouse promoter. This model was generated by intercrossing hCTLA-4 and hLAG3 mice. Learn more


hGITR-Foxp3

Target: GITR & Foxp3                    

hGITR mice were crossed with Foxp3-IRES-mRFP (FIR) reporter mice to monitor Treg activity. The FIR's bicistronic reporter expressing a red fluorescent protein has been knocked into the endogenous Foxp3 locus and faithfully mirrors Foxp3 expression. Learn more