Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.

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Applications & Features

Target-specific humanized models provide a robust platform for advancing drug development and therapeutic research across a wide range of biomedical fields, including oncology, immunology, and inflammation.

These models enable predictive and translational preclinical research, supporting diverse applications such as:

Evaluating the efficacy of T-cell engagers (e.g., Pan hCD3 model), biologics, and small molecules (e.g., hTFRC)
Investigating immune checkpoints and assessing them as potential drug targets (e.g., hPD-1 and hVISTA)
Testing antibody-dependent therapies (e.g., hFcgR)
Conducting pharmacokinetic (PK) analysis (e.g., HSA/hFcRn)

Immunocompetent and free from murine target gene expression, the models exhibit physiological, human-like target expression while preserving critical cell/cell and ligand/target interactions. These features make them an invaluable resource for syngeneic studies.

Nup88

|

Nucleoporin 88

Synonyms:

Nucleoporin 88kDa, Nup84, Prei2

Gene ID (NCBI):

19069

Protein function:

Component of the nuclear pore complex; involved in nucleocytoplasmic transport.

Applications:

Studies on nuclear transport and gene regulation.

Mapk11

|

Mitogen-activated protein kinase 11

Synonyms:

p38β, SAPK2, PRKM11

Gene ID (NCBI):

19094

Protein function:

Serine/threonine kinase involved in stress response and inflammation signaling.

Applications:

Research on MAPK signaling pathways and inflammation.

Ppp5c

|

Protein phosphatase 5 catalytic subunit

Synonyms:

Protein phosphatase 5, PP5

Gene ID (NCBI):

19060

Protein function:

Serine/threonine phosphatase involved in stress response and cell cycle regulation.

Applications:

Research on stress signaling and cell cycle control.

Ppp3cc

|

Protein phosphatase 3 catalytic subunit gamma

Synonyms:

Calcineurin A gamma, PP2B-A gamma

Gene ID (NCBI):

19057

Protein function:

Calcium/calmodulin-dependent protein phosphatase involved in T-cell activation.

Applications:

Studies on immune signaling and T-cell activation.

Ppm1a

|

Protein phosphatase 1A, magnesium-dependent, alpha isoform

Synonyms:

Protein phosphatase 1A, PP2C-alpha

Gene ID (NCBI):

19042

Protein function:

Serine/threonine phosphatase involved in stress response and cell cycle control.

Applications:

Research on cell cycle and stress signaling pathways.

Plxna2

|

Plexin A2

Synonyms:

KIAA0463, OCT

Gene ID (NCBI):

18845

Protein function:

Receptor for semaphorins; involved in axon guidance and neuronal development.

Applications:

Studies on neural development and guidance cues.

Pa2g4

|

Proliferation-associated 2G4

Synonyms:

EBP1, ErbB3-binding protein 1, p38-2G4

Gene ID (NCBI):

18813

Protein function:

Involved in cell proliferation and differentiation; interacts with ErbB3 receptor.

Applications:

Research on cell cycle regulation and oncology.

Pla2g2c

|

Phospholipase A2 group IIC

Synonyms:

UBXN10-AS1

Gene ID (NCBI):

18781

Protein function:

Enzyme involved in phospholipid metabolism; may play a role in inflammation.

Applications:

Research on lipid metabolism and inflammation.

Prkcz

|

Protein kinase C, zeta

Synonyms:

PKCζ, aPKCζ

Gene ID (NCBI):

18762

Protein function:

Atypical protein kinase C involved in signal transduction pathways.

Applications:

Research on signal transduction and disease mechanisms.

Plau

|

Plasminogen activator, urokinase

Synonyms:

Urokinase-type plasminogen activator, UPA

Gene ID (NCBI):

18792

Protein function:

Converts plasminogen to plasmin, involved in fibrinolysis and tissue remodeling.

Applications:

Studies on cancer progression and thrombosis.

Pkig

|

Protein kinase inhibitor gamma

Synonyms:

PKIγ, cAMP-dependent protein kinase inhibitor gamma

Gene ID (NCBI):

18769

Protein function:

Inhibits cAMP-dependent protein kinase activity, regulating signal transduction pathways.

Applications:

Studies on cAMP signaling and metabolic regulation.

Pdgfrb

|

Platelet derived growth factor receptor beta polypeptide

Synonyms:

PDGFR-β

Gene ID (NCBI):

18596

Protein function:

Receptor tyrosine kinase involved in cell proliferation and development.

Applications:

Studies on angiogenesis and tissue regeneration.

Pfn1

|

Profilin 1

Synonyms:

Profilin 1, actin binding protein

Gene ID (NCBI):

18643

Protein function:

Actin-binding protein regulating cytoskeletal dynamics.

Applications:

Research on cytoskeleton and neurodegenerative diseases.

Pde8a

|

Phosphodiesterase 8A

Synonyms:

Pde8

Gene ID (NCBI):

18584

Protein function:

Enzyme hydrolyzing cAMP, regulating intracellular signaling pathways.

Applications:

Research on signal transduction and pharmacology.

Pitx2

|

Paired-like homeodomain transcription factor 2

Synonyms:

Brx1, Munc30, Rieg

Gene ID (NCBI):

18741

Protein function:

Transcription factor involved in organ development and left-right asymmetry.

Applications:

Studies on developmental biology and congenital disorders.

Pfkl

|

Phosphofructokinase, liver, B-type

Synonyms:

Pfk-liver, Pfk

Gene ID (NCBI):

18641

Protein function:

Key glycolytic enzyme converting fructose-6-phosphate to fructose-1,6-bisphosphate.

Applications:

Studies on energy metabolism and enzymopathies.

Per2

|

Period circadian clock 2

Synonyms:

Period circadian protein homolog 2

Gene ID (NCBI):

18627

Protein function:

Core component of the circadian clock regulating biological rhythms.

Applications:

Research on chronobiology and metabolic regulation.

Pbx3

|

Pre B cell leukemia homeobox 3

Synonyms:

Pre-B-cell leukemia transcription factor 3

Gene ID (NCBI):

18516

Protein function:

Transcription factor involved in developmental processes and hematopoiesis.

Applications:

Research on developmental biology and oncology.

Pcx

|

Pyruvate carboxylase

Synonyms:

Pc

Gene ID (NCBI):

18563

Protein function:

Enzyme catalyzing the carboxylation of pyruvate to oxaloacetate, key in gluconeogenesis.

Applications:

Studies on metabolism and energy homeostasis.

Pax5

|

Paired box 5

Synonyms:

EBB-1, Pax-5

Gene ID (NCBI):

18507

Protein function:

Transcription factor essential for B-cell lineage commitment and development.

Applications:

Studies on immune system development and hematological malignancies.

P2rx7

|

Purinergic receptor P2X, ligand-gated ion channel 7

Synonyms:

P2X7, P2X7R

Gene ID (NCBI):

18439

Protein function:

ATP-gated ion channel involved in inflammation and cell death.

Applications:

Studies on immune response and neuroinflammation.

P2rx4

|

Purinergic receptor P2X, ligand-gated ion channel 4

Synonyms:

P2X4

Gene ID (NCBI):

18438

Protein function:

ATP-gated ion channel involved in synaptic transmission and inflammation.

Applications:

Research on pain mechanisms and vascular function.

P2rx6

|

Purinergic receptor P2X, ligand-gated ion channel 6

Synonyms:

P2X6, P2rxl1, P2xm

Gene ID (NCBI):

18440

Protein function:

ATP-gated ion channel; forms heteromeric channels with other P2X subunits.

Applications:

Research on nociception and vascular biology.

Pak1

|

p21 (RAC1) activated kinase 1

Synonyms:

PAK-1, p21-activated kinase 1

Gene ID (NCBI):

18479

Protein function:

Serine/threonine kinase involved in cytoskeletal remodeling and cell motility.

Applications:

Studies on cell signaling, cancer, and metabolism.

Mybbp1a

|

MYB binding protein (P160) 1a

Synonyms:

P160, Myb-binding protein 1a

Gene ID (NCBI):

18432

Protein function:

Transcriptional regulator involved in ribosome biogenesis and p53 activation.

Applications:

Studies on transcription regulation and tumorigenesis.

Slc25a15

|

Solute carrier family 25 member 15

Synonyms:

Ornt1, D630044L02Rik

Gene ID (NCBI):

18408

Protein function:

Mitochondrial ornithine transporter; essential for urea cycle function.

Applications:

Metabolic disorder models, urea cycle studies.

Nxn

|

Nucleoredoxin

Synonyms:

-

Gene ID (NCBI):

18230

Protein function:

Redox-regulating protein that modulates Wnt signaling by interacting with Dishevelled proteins.

Applications:

Research on redox biology and Wnt signaling.

Ntrk2

|

Neurotrophic tyrosine kinase, receptor, type 2

Synonyms:

TrkB, Trk-B

Gene ID (NCBI):

18212

Protein function:

Receptor for BDNF and NT-4; involved in CNS development and synaptic plasticity.

Applications:

Studies on neurodevelopment and metabolic disorders.

Emc8

|

ER membrane protein complex subunit 8

Synonyms:

-

Gene ID (NCBI):

18117

Protein function:

Part of the ER membrane protein complex; assists in membrane protein insertion.

Applications:

Research on ER function and protein biogenesis.

Ntrk1

|

Neurotrophic tyrosine kinase, receptor, type 1

Synonyms:

TrkA, Trk, Tkr

Gene ID (NCBI):

18211

Protein function:

High-affinity receptor for nerve growth factor; critical for neuronal survival and differentiation.

Applications:

Neurological disorder models, pain research.

Npc1

|

NPC intracellular cholesterol transporter 1

Synonyms:

Niemann-Pick disease, type C1

Gene ID (NCBI):

18145

Protein function:

Mediates intracellular cholesterol trafficking; essential for lipid homeostasis.

Applications:

Models for lipid storage disorders and neurodegeneration.

Nras

|

Neuroblastoma RAS viral oncogene homolog

Synonyms:

N-ras, c-N-Ras

Gene ID (NCBI):

18176

Protein function:

GTPase involved in cell proliferation and differentiation via MAPK/ERK pathway.

Applications:

Cancer research, developmental biology.

Uhrf1

|

Ubiquitin-like with PHD and RING finger domains 1

Synonyms:

ICBP90, Np95

Gene ID (NCBI):

18140

Protein function:

Epigenetic regulator; links DNA methylation and histone modification.

Applications:

Studies on epigenetic regulation and gene silencing.

Notch1

|

Notch 1

Synonyms:

Notch homolog 1

Gene ID (NCBI):

18128

Protein function:

Transmembrane receptor involved in cell fate decisions.

Applications:

Research on cell differentiation and oncogenesis.

Nodal

|

Nodal growth differentiation factor

Synonyms:

-

Gene ID (NCBI):

18119

Protein function:

Secreted ligand of the TGF-beta superfamily; regulates embryonic development.

Applications:

Studies on embryogenesis and developmental biology.

Nmt2

|

N-myristoyltransferase 2

Synonyms:

-

Gene ID (NCBI):

18108

Protein function:

Catalyzes N-terminal myristoylation of proteins; important for membrane targeting.

Applications:

Studies on protein modification and signal transduction.

Nipsnap1

|

Nipsnap homolog 1

Synonyms:

-

Gene ID (NCBI):

18082

Protein function:

Involved in mitophagy and pain transmission.

Applications:

Research on mitochondrial quality control and neuropathies.

Nfatc3

|

Nuclear factor of activated T cells, cytoplasmic 3

Synonyms:

NFAT4, NFATx

Gene ID (NCBI):

18021

Protein function:

Transcription factor involved in immune response regulation.

Applications:

Studies on T-cell activation and immune regulation.

Naga

|

N-acetyl galactosaminidase, alpha

Synonyms:

Alpha-N-acetylgalactosaminidase

Gene ID (NCBI):

17939

Protein function:

Lysosomal enzyme that degrades glycoproteins and glycolipids.

Applications:

Research on lysosomal storage disorders.

Napb

|

N-ethylmaleimide sensitive fusion protein attachment protein beta

Synonyms:

Beta-soluble NSF attachment protein

Gene ID (NCBI):

17957

Protein function:

Involved in vesicle fusion and neurotransmitter release at synapses.

Applications:

Studies on synaptic function and neurological disorders.

Ncoa3

|

Nuclear receptor coactivator 3

Synonyms:

AIB1, SRC-3, RAC3, TRAM-1, pCIP, KAT13B

Gene ID (NCBI):

17979

Protein function:

Coactivator for nuclear receptors; enhances transcriptional activation.

Applications:

Studies on hormone-dependent cancers and gene regulation.

Ncf2

|

Neutrophil cytosolic factor 2

Synonyms:

NOXA2, p67phox

Gene ID (NCBI):

17970

Protein function:

Component of NADPH oxidase complex; generates reactive oxygen species in immune response.

Applications:

Models for studying immune deficiencies and oxidative stress.

Nedd4

|

Neural precursor cell expressed, developmentally down-regulated 4

Synonyms:

Nedd4-1, Nedd4a, E430025J12Rik

Gene ID (NCBI):

17999

Protein function:

E3 ubiquitin-protein ligase; regulates protein degradation.

Applications:

Research on protein ubiquitination and neuronal development.

Myo7a

|

Myosin VIIA

Synonyms:

Usher syndrome type 1B protein

Gene ID (NCBI):

17921

Protein function:

Unconventional myosin involved in sensory functions, including hearing and vision.

Applications:

Studies on sensory organ development and function.

Myl4

|

Myosin, light polypeptide 4

Synonyms:

ALC-1, ELC, ELC1a, GT1, AMLC

Gene ID (NCBI):

17896

Protein function:

Light chain of myosin involved in muscle contraction, especially in atrial muscle.

Applications:

Research on cardiac muscle function and arrhythmias.

Myh9

|

Myosin, heavy polypeptide 9, non-muscle

Synonyms:

NMHC-IIA, NMMHC-IIA

Gene ID (NCBI):

17886

Protein function:

Non-muscle myosin involved in cell motility, adhesion, and cytokinesis.

Applications:

Studies on cytoskeletal dynamics and related diseases.

Myd88

|

Myeloid differentiation primary response gene 88

Synonyms:

-

Gene ID (NCBI):

17874

Protein function:

Adapter protein in Toll-like and IL-1 receptor signaling pathways; crucial for innate immunity.

Applications:

Research on innate immune signaling and inflammation.

Myl2

|

Myosin, light polypeptide 2, regulatory, cardiac, slow

Synonyms:

RLC-2, MLC-2v

Gene ID (NCBI):

17906

Protein function:

Regulatory light chain of myosin in cardiac muscle; modulates contraction.

Applications:

Models for heart development and cardiomyopathy.

Mybpc3

|

Myosin binding protein C, cardiac

Synonyms:

cMyBP-C

Gene ID (NCBI):

17868

Protein function:

Structural protein in cardiac sarcomere; regulates cardiac muscle contraction.

Applications:

Models for cardiomyopathy and heart disease.

Mx1

|

MX dynamin-like GTPase 1

Synonyms:

Mx, Mx-1

Gene ID (NCBI):

17857

Protein function:

Interferon-induced GTPase with antiviral activity against influenza and other viruses.

Applications:

Studies on innate immunity and antiviral responses.

Msh5

|

MutS homolog 5

Synonyms:

G7, MutS homolog 5

Gene ID (NCBI):

17687

Protein function:

DNA mismatch repair protein involved in meiotic recombination and genomic stability.

Applications:

Studies on DNA repair and meiosis.

Cxcl9

|

C-X-C motif chemokine ligand 9

Synonyms:

MIG, CMK, SCYB9, CRG-10

Gene ID (NCBI):

17329

Protein function:

Chemokine induced by interferon-gamma; involved in T-cell trafficking and immune responses.

Applications:

Research on chemokine signaling and immune cell migration.

Mmp16

|

Matrix metallopeptidase 16

Synonyms:

MT3-MMP

Gene ID (NCBI):

17389

Protein function:

Membrane-type metalloproteinase involved in activation of other MMPs and extracellular matrix degradation.

Applications:

Research on extracellular matrix dynamics and cancer.

Mmp12

|

Matrix metallopeptidase 12

Synonyms:

MME, ME, Macrophage elastase

Gene ID (NCBI):

17381

Protein function:

Metalloproteinase involved in extracellular matrix remodeling and tissue repair.

Applications:

Studies on tissue remodeling and inflammatory diseases.

Mapkapk5

|

Mitogen-activated protein kinase-activated protein kinase 5

Synonyms:

MK5, PRAK, MAPKAP-K5

Gene ID (NCBI):

17165

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in cell differentiation and apoptosis.

Applications:

Studies on cell cycle regulation and apoptosis.

Marco

|

Macrophage receptor with collagenous structure

Synonyms:

SCARA2, SR-A6

Gene ID (NCBI):

17167

Protein function:

Scavenger receptor involved in innate immunity and binding of bacterial pathogens.

Applications:

Research on innate immunity and pathogen recognition.

Mgat1

|

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase

Synonyms:

GLCNAC-TI, GLCT1, GLYT1

Gene ID (NCBI):

17308

Protein function:

Enzyme involved in N-glycan biosynthesis; initiates complex N-linked carbohydrate formation.

Applications:

Studies on glycosylation and protein processing.

Mapkapk2

|

Mitogen-activated protein kinase-activated protein kinase 2

Synonyms:

MK2, MAPKAP-K2

Gene ID (NCBI):

17164

Protein function:

Serine/threonine kinase activated by p38 MAPK; involved in stress and inflammatory responses.

Applications:

Research on inflammation and stress signaling pathways.

Lyn

|

LYN proto-oncogene, Src family tyrosine kinase

Synonyms:

p53Lyn, p56Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Gene ID (NCBI):

17096

Protein function:

Non-receptor tyrosine kinase involved in B-cell receptor signaling and regulation of immune responses.

Applications:

Studies on immune signaling and autoimmune disorders.

Cep250

|

Centrosomal protein 250

Synonyms:

C-Nap1

Gene ID (NCBI):

16328

Protein function:

Component of the centrosome involved in centrosome cohesion during interphase.

Applications:

Studies on cell division and sensory disorders.

Lrrc23

|

Leucine rich repeat containing 23

Synonyms:

LRPB7, Leucine-rich repeat-containing protein 23

Gene ID (NCBI):

16977

Protein function:

Predicted to be involved in sperm motility and radial spoke assembly; contains leucine-rich repeats.

Applications:

Studies on reproductive biology and ciliary function.

Lrmp

|

Lymphoid-restricted membrane protein

Synonyms:

IRAG2, JAW1, Lymphoid-restricted membrane protein

Gene ID (NCBI):

16970

Protein function:

Involved in calcium signaling and immune cell function; interacts with inositol 1,4,5-trisphosphate receptors.

Applications:

Research on lymphocyte signaling and immune responses.

Lmnb1

|

Lamin B1

Synonyms:

Lamin B1

Gene ID (NCBI):

16906

Protein function:

Structural component of the nuclear lamina; maintains nuclear integrity and regulates gene expression.

Applications:

Studies on nuclear architecture and neurodegenerative diseases.

Lifr

|

Leukemia inhibitory factor receptor

Synonyms:

LIF receptor subunit alpha, CD118

Gene ID (NCBI):

16880

Protein function:

Receptor for leukemia inhibitory factor; involved in cell differentiation, survival, and proliferation.

Applications:

Research on cytokine signaling and developmental biology.

Lepr

|

Leptin receptor

Synonyms:

LEP-R, OB-R, CD295, LEPRD, DB

Gene ID (NCBI):

16847

Protein function:

Receptor for leptin; regulates body weight, energy expenditure, and neuroendocrine function.

Applications:

Studies on obesity, metabolism, and endocrine function.

Ldlr

|

Low density lipoprotein receptor

Synonyms:

Low-density lipoprotein receptor, Hlb301

Gene ID (NCBI):

16835

Protein function:

Mediates endocytosis of cholesterol-rich LDL particles; crucial for cholesterol homeostasis.

Applications:

Research on lipid metabolism and cardiovascular diseases.

Ldha

|

Lactate dehydrogenase A

Synonyms:

Ldh1, Ldhm, L7R2

Gene ID (NCBI):

16828

Protein function:

Catalyzes conversion of pyruvate to lactate during anaerobic glycolysis; important in muscle metabolism.

Applications:

Studies on energy metabolism and cancer.

Lama1

|

Laminin subunit alpha-1

Synonyms:

Laminin A chain, Laminin-1 subunit alpha, S-LAM alpha

Gene ID (NCBI):

16772

Protein function:

Major component of basement membranes; involved in cell adhesion, differentiation, and migration.

Applications:

Studies on extracellular matrix and developmental biology.

Lbp

|

Lipopolysaccharide binding protein

Synonyms:

Lipopolysaccharide-binding protein, Bpifd2

Gene ID (NCBI):

16803

Protein function:

Binds bacterial lipopolysaccharides (LPS) and transfers them to CD14 and TLR4, initiating immune responses.

Applications:

Research on innate immunity and sepsis models.

Klkb1

|

Kallikrein B, plasma 1

Synonyms:

Plasma kallikrein

Gene ID (NCBI):

16621

Protein function:

Serine protease involved in the kallikrein-kinin system, affecting blood pressure and inflammation.

Applications:

Research on coagulation and inflammatory pathways.

Sspn

|

Sarcospan

Synonyms:

Sarcospan

Gene ID (NCBI):

16651

Protein function:

Component of the dystrophin-glycoprotein complex, contributing to muscle membrane stability.

Applications:

Studies on muscle integrity and dystrophin complex.

Aff3

|

AF4/FMR2 family member 3

Synonyms:

LAF4

Gene ID (NCBI):

16764

Protein function:

Transcriptional activator involved in lymphoid development and gene regulation.

Applications:

Research on transcriptional regulation and lymphoid development.

Kif3b

|

Kinesin family member 3B

Synonyms:

-

Gene ID (NCBI):

16569

Protein function:

Component of the kinesin-II complex involved in intraflagellar transport and cilia function.

Applications:

Studies on cilia function and embryonic development.

Kcnj12

|

Potassium inwardly-rectifying channel, subfamily J, member 12

Synonyms:

Kir2.2

Gene ID (NCBI):

16515

Protein function:

Inward rectifier potassium channel contributing to cardiac and skeletal muscle excitability.

Applications:

Research on cardiac electrophysiology and muscle function.

Kif13b

|

Kinesin family member 13B

Synonyms:

GAKIN

Gene ID (NCBI):

16554

Protein function:

Microtubule-based motor protein involved in intracellular transport and myelination.

Applications:

Research on axonal transport and myelination.

Kcnj9

|

Potassium inwardly-rectifying channel, subfamily J, member 9

Synonyms:

Kir3.3

Gene ID (NCBI):

16524

Protein function:

G protein-activated inward rectifier potassium channel involved in regulating neuronal excitability.

Applications:

Studies on G protein signaling and neuronal function.

Kcnj11

|

Potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:

Kir6.2

Gene ID (NCBI):

16514

Protein function:

Forms ATP-sensitive potassium channels regulating insulin secretion in pancreatic beta cells.

Applications:

Studies on insulin secretion and diabetes.

Kcnb1

|

Potassium voltage-gated channel subfamily B member 1

Synonyms:

Kv2.1

Gene ID (NCBI):

16500

Protein function:

Delayed rectifier potassium channel involved in action potential repolarization in neurons.

Applications:

Research on neuronal excitability and epilepsy.

Itgae

|

Integrin alpha E

Synonyms:

CD103

Gene ID (NCBI):

16407

Protein function:

Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.

Applications:

Studies on mucosal immunity and T-cell localization.

Itga2

|

Integrin subunit alpha 2

Synonyms:

Integrin alpha-2, CD49b

Gene ID (NCBI):

16398

Protein function:

Integrin alpha chain involved in cell adhesion and recognition in a variety of processes including embryogenesis and hemostasis.

Applications:

Research on cell adhesion and hemostasis.

Il15

|

Interleukin 15

Synonyms:

IL-15

Gene ID (NCBI):

16168

Protein function:

Cytokine that stimulates the proliferation of T lymphocytes and is involved in the development of NK cells.

Applications:

Research on immune cell development and cytokine therapy.

Itch

|

Itchy homolog (mouse)

Synonyms:

Itchy E3 ubiquitin protein ligase

Gene ID (NCBI):

16396

Protein function:

E3 ubiquitin ligase involved in the regulation of immune responses and protein degradation.

Applications:

Studies on protein ubiquitination and immune regulation.

Irf1

|

Interferon regulatory factor 1

Synonyms:

IRF-1

Gene ID (NCBI):

16362

Protein function:

Transcription factor that regulates the expression of interferons and other genes involved in immune responses.

Applications:

Research on immune regulation and transcriptional control.

Irak1

|

Interleukin-1 receptor-associated kinase 1

Synonyms:

IRAK-1

Gene ID (NCBI):

16179

Protein function:

Kinase involved in the Toll-like receptor and IL-1 receptor signaling pathways, leading to NF-κB activation.

Applications:

Studies on innate immunity and inflammatory signaling.

Lrig1

|

Leucine-rich repeats and immunoglobulin-like domains 1

Synonyms:

LRIG1

Gene ID (NCBI):

16206

Protein function:

Transmembrane protein that negatively regulates receptor tyrosine kinases, involved in stem cell maintenance.

Applications:

Research on stem cell biology and cancer.

Id2

|

Inhibitor of DNA Binding 2

Synonyms:

-

Gene ID (NCBI):

15902

Protein function:

Transcriptional regulator that inhibits DNA binding of basic helix-loop-helix proteins.

Applications:

Immune system and developmental studies

Ido1

|

Indoleamine 2,3-Dioxygenase 1

Synonyms:

-

Gene ID (NCBI):

15930

Protein function:

Catalyzes the first step in tryptophan catabolism; modulates immune response.

Applications:

Immunotherapy and metabolic studies

Il12a

|

Interleukin 12a

Synonyms:

IL-12p35

Gene ID (NCBI):

16159

Protein function:

Subunit of the cytokine IL-12, involved in the differentiation of naive T cells into Th1 cells.

Applications:

Research on immune responses and cytokine signaling.

Il13ra2

|

Interleukin 13 receptor, alpha 2

Synonyms:

IL-13Rα2

Gene ID (NCBI):

16165

Protein function:

High-affinity receptor for IL-13, acts as a decoy receptor modulating IL-13 activity.

Applications:

Studies on cytokine signaling and immune regulation.

Ikbkb

|

Inhibitor of kappaB kinase beta

Synonyms:

IKKβ, IKK2

Gene ID (NCBI):

16150

Protein function:

Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.

Applications:

Studies on NF-κB signaling, inflammation, and immune responses.

Ifnar1

|

Interferon Alpha and Beta Receptor Subunit 1

Synonyms:

Ifar, Ifrc

Gene ID (NCBI):

15975

Protein function:

Part of the receptor for type I interferons; mediates antiviral responses.

Applications:

Viral infection and immune response studies

Ide

|

Insulin Degrading Enzyme

Synonyms:

-

Gene ID (NCBI):

15925

Protein function:

Degrades insulin and other peptides; involved in glucose metabolism.

Applications:

Metabolic and neurodegenerative disease models

Prmt1

|

Protein Arginine Methyltransferase 1

Synonyms:

Hrmt1l2

Gene ID (NCBI):

15469

Protein function:

Major type I arginine methyltransferase; modifies histones and other proteins.

Applications:

Gene expression and developmental studies

Trmt2a

|

tRNA Methyltransferase 2 Homolog A

Synonyms:

-

Gene ID (NCBI):

15547

Protein function:

Methylates uridine residues in tRNA; involved in RNA processing.

Applications:

RNA modification and processing studies

Prmt2

|

Protein Arginine Methyltransferase 2

Synonyms:

Hrmt1l1

Gene ID (NCBI):

15468

Protein function:

Enzyme that methylates arginine residues on histones and other proteins.

Applications:

Epigenetic regulation and developmental studies

Hprt

|

Hypoxanthine Phosphoribosyltransferase 1

Synonyms:

Hprt1

Gene ID (NCBI):

15452

Protein function:

Enzyme in purine salvage pathway; converts hypoxanthine to IMP.

Applications:

Purine metabolism and neurological disorder models

Hp1bp3

|

Heterochromatin Protein 1 Binding Protein 3

Synonyms:

Hp1bp74

Gene ID (NCBI):

15441

Protein function:

Chromatin-binding protein involved in gene expression regulation.

Applications:

Epigenetics and gene expression studies

Hira

|

Histone cell cycle regulator

Synonyms:

DiGeorge syndrome critical region gene 1

Gene ID (NCBI):

15260

Protein function:

Histone chaperone involved in nucleosome assembly and chromatin remodeling.

Applications:

Research on chromatin assembly and developmental biology.

Hoxa2

|

Homeobox A2

Synonyms:

Hox-1.11, Hox1a

Gene ID (NCBI):

15399

Protein function:

Transcription factor involved in craniofacial and skeletal development.

Applications:

Craniofacial development studies

Hmox2

|

Heme oxygenase 2

Synonyms:

HO-2, HO2

Gene ID (NCBI):

15369

Protein function:

Enzyme that degrades heme to biliverdin, carbon monoxide, and free iron.

Applications:

Studies on oxidative stress and neuroprotection.

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(Sensei) Conditionally active CD28xVISTA bispecific antibodies induce myeloid-driven tumor-specific T-cell co-stimulation for improved cancer immunotherapy

CD28xVISTA bispecific antibodies in immunotherapy

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CD28 humanized mouse model for efficacy and safety assessment of CD28-targeting therapies

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Cell-depleting agents assessment in preclinical models

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hPD-1 mice as a model to evaluate human specific PD-1 therapeutics

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

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VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

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Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas

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Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

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Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

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Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9

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Modification of BRCA1-associated breast cancer risk by HMMR overexpression

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Molybdenum cofactor deficiency type B knock-in mouse models carrying patient-identical mutations and their rescue by singular AAV injections

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An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes

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Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression

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Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen.

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Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop.

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C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.

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Generation of a double transgenic humanised neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs

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Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

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Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

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Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

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Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

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Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

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The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model

Blood

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

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Abnormal Cognition Sleep EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse PLB1.

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Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

J Pharmacol Exp Ther

A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies

Humanized ICP in immuno-oncology

Part 1: Toward a better effective preclinical model in immuno-oncology

Immuno-oncolology models

A VISTA on naive T cell fate

Humanized ICP mouse

Part 4: Humanized immune checkpoint mouse models for immuno-oncology studies

Immuno-oncolology models

HSA/hFcRn, a powerful model for your PK/PD studies

Immuno-oncolology models

Define “humanized”: two mouse models helping produce cancer immunotherapies

Humanized mouse models

A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers

T-cell engager

Uncoupling toxicity from therapeutic efficacy: the new challenge of immunotherapies

Assess toxicity with ICP

Uncoupling toxicity from therapeutic efficacy: a case study on ATOR-1015

Bispecific antibodies

Uncoupling efficacy from toxicity: a case study on MEDI5752

Bispecific antibodies

The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R

Physiological relevancy in preclinical models

Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies

Therapeutic efficacy and pharmacokinetics

Relevant preclinical models to test T-cell engagers: The case of CD28

T-cell engager

An alternative approach to immunotherapy: A bispecific agonist

Humanized PD-1 & GITR mouse

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

T-cell engager CD3

Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help

Assess T-cell engager in BRGSF-HIS

A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway

Humanized PD-1/PD-L1 mouse and cell line

An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Humanized HSA/hFcRn mouse

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Humanized ICP mouse and cell lines

Assessing T-cell engagers efficacy in vivo: Versatility of BRGSF-HIS mice

Assess T-cell engager in BRGSF-HIS

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Humanized VISTA mouse & Pharmacokinetics

An engineered humanized common light chain mouse model to develop bispecific antibodies

Humanized cLC model - Bispecific antibody development

Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized genO-hCD47/hSIRPα mouse and genO-MC38-hPD-L1-hCD47-LZ cell line

Targeting the human CD47/SIRPα axis

BRGSF-HIS: genOway’s mouse model to evaluate the pathogenesis of Staphylococcus aureus Panton-Valentine leukocidin in acute implant-associated osteomyelitis

BRGSF-HIS as model for acute implant-associated osteomyelitis

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

VISTA - safety and PK profiling

HPN328, a new T cell–activating construct for treating solid tumors

CD3ε - T-cell engager assessment

Development of a new antibody-drug conjugate against CD71, INA03, for the treatment of leukemia

TFRC for anti-cancer therapies

New CD4-specific minibodies to predict cancer treatment outcomes

CD4 for cancer treatment outcomes

A radiolabeled VISTA antibody for imaging VISTA expression

hVISTA - antibodies & PET imaging

Targeted immunotherapy against autoreactive B cells in autoimmune diseases

T-cell engagers in immunotherapies

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Other categories

Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.

Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.

Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.