Humanized mice (target-specific)

Involved in synaptic function and possibly iron regulation

Studied in sleep, motor control, and neurological traits

Epc2

|

Enhancer of polycomb homolog 2

Synonyms:

—

Gene ID (NCBI):

227867

Involved in chromatin remodeling and transcriptional repression

Studied in epigenetic regulation and hematopoiesis

Klrb1

|

Killer cell lectin-like receptor subfamily B member 1

Synonyms:

Nkrp1, Nkrp1a, Cd161

Gene ID (NCBI):

100043861

Lectin-like receptor involved in NK cell activation and immune modulation

Model for NK cell biology, immunoregulation, and inflammation

Mthfsl

|

Methenyltetrahydrofolate synthetase-like

Synonyms:

4933427C07Rik

Gene ID (NCBI):

100039707

Predicted folate metabolism enzyme; function not fully validated

Used in exploratory studies of folate metabolism

Pex10

|

Peroxisomal biogenesis factor 10

Synonyms:

—

Gene ID (NCBI):

668173

E3 ubiquitin ligase required for peroxisome assembly and matrix protein import

Model for peroxisome biogenesis and metabolic disorders

Mthfd2l

|

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent)-like

Synonyms:

Mthfd2-like

Gene ID (NCBI):

665563

Enzyme in mitochondrial folate metabolism; role not fully elucidated

Studied in mitochondrial folate pathways and metabolism

Gsk3a

|

Glycogen synthase kinase 3 alpha

Synonyms:

Gsk3-alpha

Gene ID (NCBI):

606496

Ser/Thr kinase regulating glycogen metabolism, Wnt signaling, cell survival

Model in signaling pathways, metabolic and neurodegenerative diseases

Cbx6

|

Chromobox 6

Synonyms:

—

Gene ID (NCBI):

494448

Epigenetic reader; binds methylated histones and represses gene expression via PRC1

Used in studies of Polycomb repression and stem cell regulation

Cnbd1

|

Cyclic nucleotide binding domain containing 1

Synonyms:

Cmpy, Cmpy-1

Gene ID (NCBI):

435772

May bind cyclic nucleotides; suggested role in cAMP signaling; function not well defined

Investigated in signaling pathway studies

Fbxl7

|

F-box and leucine-rich repeat protein 7

Synonyms:

—

Gene ID (NCBI):

448987

Component of SCF ubiquitin ligase complex; involved in targeting proteins for degradation

Model for protein degradation and tumor suppression

Ccdc160

|

Coiled-coil domain containing 160

Synonyms:

—

Gene ID (NCBI):

434778

Poorly characterized protein with coiled-coil motifs; function unknown

Exploratory studies in protein-protein interaction and structural genomics

Hdac1

|

Histone deacetylase 1

Synonyms:

Rpd3

Gene ID (NCBI):

433759

Epigenetic regulator; removes acetyl groups from histones, modulating transcription

Widely used in epigenetics and cancer research

Adcy1

|

Adenylate cyclase 1 (brain)

Synonyms:

AC1

Gene ID (NCBI):

432530

Converts ATP to cAMP; calcium/calmodulin-regulated; key in brain signaling

Model for learning, memory, and signal transduction

Primpol

|

Primase and polymerase

Synonyms:

Ccdc111

Gene ID (NCBI):

408022

Involved in translesion synthesis and DNA repair during replication stress

Used in DNA repair and replication stress response models

Krt74

|

Keratin 74

Synonyms:

Hha6, K6irs1

Gene ID (NCBI):

406222

Structural protein in hair follicles and inner root sheath

Used in studies of hair development and skin disorders

Cdsn

|

Corneodesmosin

Synonyms:

—

Gene ID (NCBI):

386463

Structural protein of desmosomes in epidermis; important in skin cohesion

Model for epidermal biology and barrier dysfunction diseases

Fam47e

|

Family with sequence similarity 47, member E

Synonyms:

4931413G21Rik

Gene ID (NCBI):

384198

Function unknown; contains conserved domains of unknown function

Exploratory gene in transcriptome and function prediction studies

Kng2

|

Kininogen 2

Synonyms:

Tkininogen, Kng-2

Gene ID (NCBI):

385643

Precursor of kinin peptides involved in vasodilation and inflammation

Model for inflammation, blood pressure regulation, and pain

Tcaim

|

T cell activation inhibitor, mitochondrial

Synonyms:

Tisp40, 2310005E10Rik

Gene ID (NCBI):

382117

May modulate T-cell activation and immune response; mitochondrial protein

Model for T-cell regulation and mitochondrial immunology

Pabpn1l

|

Poly(A) binding protein, nuclear 1-like

Synonyms:

—

Gene ID (NCBI):

382035

Involved in mRNA processing and polyadenylation in oocytes

Used in reproductive biology and maternal effect gene studies

Gse1

|

Genetic suppressor element 1

Synonyms:

KIAA0182

Gene ID (NCBI):

382034

Involved in chromatin remodeling and transcriptional repression

Used in cancer biology and transcriptional regulation models

Prmt8

|

Protein arginine methyltransferase 8

Synonyms:

E430014E13Rik

Gene ID (NCBI):

381813

Methylates arginine residues; neuron-specific expression; involved in signaling

Studied in neuronal signaling and epigenetic modulation

Nxpe5

|

Neurexophilin and PC-esterase domain family, member 5

Synonyms:

Neurexophilin and PC-esterase domain family member 5

Gene ID (NCBI):

381680

Uncharacterized protein; may be involved in synaptic function

Exploratory model in neurodevelopmental biology

Rbm33

|

RNA binding motif protein 33

Synonyms:

Gm586

Gene ID (NCBI):

381626

May play a role in RNA processing or stability; poorly characterized

Used in transcriptome-wide studies of RNA-binding proteins

Oog2

|

Oocyte-specific gene 2

Synonyms:

Zfp393

Gene ID (NCBI):

381570

Putative transcription factor, oocyte-specific; zinc finger protein

Used in reproductive biology and oogenesis research

Zfp69

|

Zinc finger protein 69

Synonyms:

Zfp69a, Zfp69b (paralogs)

Gene ID (NCBI):

381549

Transcriptional regulator implicated in metabolic gene control

Model for type 2 diabetes and metabolic syndrome

Mroh7

|

Maestro heat-like repeat family member 7

Synonyms:

Myosin-regulated oncogene-like protein 7

Gene ID (NCBI):

381538

Poorly characterized; predicted structural protein

Under study in gene prediction and protein structure research

Gpr176

|

G protein-coupled receptor 176

Synonyms:

A930036B03Rik

Gene ID (NCBI):

381413

Orphan GPCR; involved in circadian rhythm regulation

Used in neuroscience and circadian rhythm studies

Zfp408

|

Zinc finger protein 408

Synonyms:

—

Gene ID (NCBI):

381410

Presumed transcription factor; contains C2H2 zinc finger domains

Studied in transcriptional regulation and retinal biology

Pabpc1l

|

Poly(A) binding protein, cytoplasmic 1-like

Synonyms:

—

Gene ID (NCBI):

381404

Binds poly(A) tails of mRNAs; regulates mRNA stability and translation

Studied in mRNA regulation and reproductive biology

Parl

|

Presenilin associated rhomboid-like

Synonyms:

PSARL

Gene ID (NCBI):

381038

Mitochondrial protease involved in apoptosis and mitochondrial dynamics

Studied in neurodegeneration and mitochondrial quality control

BC055324

|

Predicted gene 657

Synonyms:

Gm657

Gene ID (NCBI):

381306

Function currently unknown; predicted coding gene

Uncharacterized, low-expression gene for exploratory studies

Med19

|

Mediator complex subunit 19

Synonyms:

Med31 (paralog)

Gene ID (NCBI):

381379

Part of the Mediator complex; bridges transcription factors and RNA polymerase II

Used in transcriptional machinery and cancer biology studies

Mks1

|

Meckel syndrome, type 1, homolog

Synonyms:

Tmem67 (paralog), Meckelin 1 (human)

Gene ID (NCBI):

380718

Centrosomal and basal body protein required for ciliogenesis

Model for cilia formation and ciliopathy pathogenesis

Agap1

|

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Synonyms:

CENTG2, AGAP-1

Gene ID (NCBI):

347722

Arf GTPase-activating protein involved in endocytic trafficking

Model for vesicular trafficking and ARF signaling

Serf2

|

Small EDRK-rich factor 2

Synonyms:

Surf1-related factor 2

Gene ID (NCBI):

378702

May regulate protein aggregation; possibly involved in aging and stress response

Used in neurodegeneration and proteostasis studies

Pram1

|

PML-RAR alpha-regulated adaptor molecule 1

Synonyms:

Myeloid nuclear differentiation antigen (MNDA)-related protein

Gene ID (NCBI):

378460

Adapter protein involved in myeloid cell signaling and immune function

Studied in hematopoiesis and immune signaling pathways

Kdm7a

|

Lysine demethylase 7A

Synonyms:

JHDM1D

Gene ID (NCBI):

338523

Histone demethylase targeting H3K9me2 and H3K27me2; involved in transcriptional regulation

Studied for epigenetic regulation and chromatin remodeling

Tmem241

|

Transmembrane protein 241

Synonyms:

—

Gene ID (NCBI):

338363

Presumed membrane protein; poorly characterized

Under investigation for general membrane biology

Acad12

|

Acyl-Coenzyme A dehydrogenase family, member 12

Synonyms:

Acyl-CoA dehydrogenase family member 12

Gene ID (NCBI):

338350

Enzyme possibly involved in branched-chain fatty acid metabolism

Used in fatty acid metabolism and energy homeostasis studies

Supv3l1

|

SUV3-like RNA helicase (S. cerevisiae)

Synonyms:

SUV3, Mtr4

Gene ID (NCBI):

338359

RNA helicase involved in mitochondrial RNA degradation and processing

Model for mitochondrial RNA metabolism and helicase function

Cog3

|

Component of oligomeric Golgi complex 3

Synonyms:

—

Gene ID (NCBI):

338337

Involved in Golgi function and protein glycosylation

Used in Golgi and vesicular trafficking research

Gm5134

|

Predicted gene, 5134

Synonyms:

—

Gene ID (NCBI):

333669

Function not characterized; predicted protein-coding gene

Currently limited to computational predictions

Card9

|

Caspase recruitment domain family, member 9

Synonyms:

Caspase recruitment domain-containing protein 9

Gene ID (NCBI):

332579

Adapter protein in innate immune signaling downstream of pattern recognition receptors

Model for innate immunity, mycosis, and inflammasome signaling

Zscan10

|

Zinc finger and SCAN domain containing 10

Synonyms:

Zfp206

Gene ID (NCBI):

332221

Transcription factor involved in stem cell maintenance and pluripotency

Used in embryonic stem cell and transcriptional regulation research

Xkrx

|

X-linked Kx blood group-related gene

Synonyms:

Xk-related protein 6 (Xkr6 – human paralog)

Gene ID (NCBI):

331524

Putative scramblase involved in phospholipid flipping during apoptosis

Investigated for roles in phospholipid asymmetry and apoptosis

Pon2

|

Paraoxonase 2

Synonyms:

Paraoxonase 2

Gene ID (NCBI):

330260

Antioxidant enzyme; hydrolyzes lactones and prevents lipid oxidation

Used in oxidative stress, inflammation, and atherosclerosis research

Slc5a6

|

Solute carrier family 5 (biotin transporter), member 6

Synonyms:

SMVT

Gene ID (NCBI):

330064

Transports biotin, pantothenate, and lipoate into cells

Model for micronutrient transport and metabolic disease

Dennd4c

|

DENN domain containing 4C

Synonyms:

DENND4C

Gene ID (NCBI):

329877

Regulator of Rab GTPase activity, possibly Rab10; involved in vesicular trafficking

Studied in vesicle trafficking and metabolic pathways

Dennd1b

|

DENN domain containing 1B

Synonyms:

FAM31B

Gene ID (NCBI):

329260

Guanine nucleotide exchange factor (GEF) for Rab35; regulates endocytosis and T cell function

Model for T cell signaling and immune regulation

Acsbg2

|

Acyl-CoA synthetase bubblegum family member 2

Synonyms:

BG2, Lpd2

Gene ID (NCBI):

328845

Activates long-chain fatty acids for lipid metabolism

Model for testis-specific lipid metabolism and fertility

Zmiz1

|

Zinc finger MIZ-type containing 1

Synonyms:

Zimp10

Gene ID (NCBI):

328365

Transcriptional co-activator; interacts with Notch and androgen receptor

Model for transcriptional co-regulation and immunity

Fads6

|

Fatty acid desaturase 6

Synonyms:

C14orf124 (human)

Gene ID (NCBI):

328035

Putative enzyme involved in fatty acid modification

Used in studies of fatty acid metabolism and regulation

Frs2

|

Fibroblast growth factor receptor substrate 2

Synonyms:

Frs2a

Gene ID (NCBI):

327826

Adapter protein in FGFR signaling pathways

Model for FGFR signaling and developmental biology

Ppfia2

|

PTPRF interacting protein alpha 2

Synonyms:

Liprin-α2

Gene ID (NCBI):

327814

Scaffolding protein involved in synapse formation and axonal transport

Used in neuronal scaffolding and synaptogenesis research

Chd7

|

Chromodomain helicase DNA binding protein 7

Synonyms:

Kismet-like protein

Gene ID (NCBI):

320790

Chromatin remodeler regulating gene expression during development

Model for CHARGE syndrome, developmental disorders

Usp44

|

Ubiquitin specific peptidase 44

Synonyms:

—

Gene ID (NCBI):

327799

Deubiquitinase regulating mitotic spindle checkpoint

Used in cell cycle, mitosis, and cancer research

Cyb5r2

|

Cytochrome b5 reductase 2

Synonyms:

Cytb5r2

Gene ID (NCBI):

320635

Enzyme involved in fatty acid desaturation and drug metabolism

Used in studies of redox reactions and metabolic pathways

Vps13c

|

Vacuolar protein sorting 13 homolog C

Synonyms:

—

Gene ID (NCBI):

320528

Involved in lipid transport at organelle contact sites

Model for Parkinson’s and lysosomal storage disorders

Dlec1

|

Deleted in lung and esophageal cancer 1

Synonyms:

HSPC122

Gene ID (NCBI):

320256

Putative tumor suppressor; may regulate cell cycle and differentiation

Model for tumor suppression and epigenetic silencing

Exph5

|

Exophilin 5

Synonyms:

Slac2-b

Gene ID (NCBI):

320051

Rab27 effector involved in vesicle transport and exocytosis

Model for vesicle dynamics and immunological skin disorders

Smyd4

|

SET and MYND domain containing 4

Synonyms:

SET and MYND domain containing 4

Gene ID (NCBI):

319822

Putative histone methyltransferase involved in transcriptional repression

Investigated in cardiac development and epigenetics

Tigar

|

TP53-induced glycolysis regulatory phosphatase

Synonyms:

C12orf5

Gene ID (NCBI):

319801

Regulates glycolysis and oxidative stress in a p53-dependent manner

Model for cancer metabolism, p53 signaling, redox control

Rfx7

|

Regulatory factor X, 7

Synonyms:

Regulatory factor X 7

Gene ID (NCBI):

319758

Transcription factor regulating immune and neuronal genes

Used in transcriptional regulation and immunity studies

Idi1

|

Isopentenyl-diphosphate delta isomerase 1

Synonyms:

Idi, Idi-1

Gene ID (NCBI):

319554

Catalyzes isomerization in cholesterol biosynthesis

Model for lipid metabolism and cholesterol biosynthesis

Dusp4

|

Dual specificity phosphatase 4

Synonyms:

MKP-2, PAC-1

Gene ID (NCBI):

319520

Deactivates MAPKs (ERK, JNK); regulates cell proliferation and immune responses

Used in MAPK pathway and immune modulation studies

Wdr59

|

WD repeat domain 59

Synonyms:

GATOR2 component WDR59

Gene ID (NCBI):

319481

GATOR2 complex member; positive regulator of mTORC1

Studied in mTORC1 pathway and nutrient response

Lix1l

|

Limb and CNS expressed 1-like

Synonyms:

Lix1-like, Lix1

Gene ID (NCBI):

280411

Expressed during limb and neural development; function not fully defined

Model for brain and limb development research

Depdc5

|

DEP domain containing 5

Synonyms:

DEPDC5

Gene ID (NCBI):

277854

Component of GATOR1 complex; negative regulator of mTORC1 pathway

Model for epilepsy, mTOR regulation, neurodevelopment

Esyt3

|

Extended synaptotagmin-like 3

Synonyms:

Extended synaptotagmin-like protein 3

Gene ID (NCBI):

272636

Involved in ER-plasma membrane tethering; lipid transport

Studied in ER-membrane contact and lipid regulation

Tmem255b

|

Transmembrane protein 255B

Synonyms:

—

Gene ID (NCBI):

272465

Predicted membrane protein; function largely uncharacterized

Used in expression studies and biomarker screening

Vps13a

|

Vacuolar protein sorting 13 homolog A

Synonyms:

Chac, chorein

Gene ID (NCBI):

271564

Involved in vesicle trafficking, lipid transport; large cytoplasmic protein

Model for neurodegeneration and lipid trafficking

Mthfd1l

|

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Synonyms:

MTHFD1-like

Gene ID (NCBI):

270685

Key enzyme in mitochondrial folate cycle and one-carbon metabolism

Model for folate metabolism and developmental biology

Elmod1

|

ELMO domain containing 1

Synonyms:

—

Gene ID (NCBI):

270162

GTPase-activating protein (GAP) for ARF family; involved in actin cytoskeleton remodeling

Model for auditory function and hair cell biology

Map3k10

|

Mitogen-activated protein kinase kinase kinase 10

Synonyms:

MLK2

Gene ID (NCBI):

269881

Activates JNK pathway; involved in neuronal apoptosis and stress signaling

Studied in JNK signaling, neurodegeneration, and apoptosis

Myo9a

|

Myosin IXA

Synonyms:

Myr7

Gene ID (NCBI):

270163

Actin-based motor with RhoGAP domain; regulates Rho GTPase signaling

Studied in cytoskeletal regulation and neural growth

Golga3

|

Golgi autoantigen, golgin subfamily a, 3

Synonyms:

Golgin-160

Gene ID (NCBI):

269682

Structural protein of the Golgi; involved in vesicle tethering and transport

Model for Golgi function and reproductive biology

Nbeal1

|

Neurobeachin-like 1

Synonyms:

Nbla10502

Gene ID (NCBI):

269198

Scaffold protein possibly involved in vesicle trafficking and secretion

Investigated for neurodevelopment and vesicle regulation

Gpr152

|

G protein-coupled receptor 152

Synonyms:

Pgr10

Gene ID (NCBI):

269053

Orphan GPCR; involved in GPCR signaling, mainly in brain

Used in neurobehavioral and pain modulation studies

Ltbp1

|

Latent transforming growth factor beta binding protein 1

Synonyms:

Ltbp-1

Gene ID (NCBI):

268977

Associates with TGF-β for extracellular matrix storage and release

Model for ECM regulation and TGF-β signaling studies

Stk32a

|

Serine/threonine kinase 32A

Synonyms:

YANK1

Gene ID (NCBI):

269019

Putative kinase involved in signal transduction; function largely unknown

Candidate in neurobiology and kinase signaling research

Capn11

|

Calpain 11

Synonyms:

—

Gene ID (NCBI):

268958

Calcium-dependent cysteine protease, testis-specific

Studied in testis biology and protease function

Brpf3

|

Bromodomain and PHD finger containing 3

Synonyms:

Br140, MYST histone acetyltransferase binding protein

Gene ID (NCBI):

268936

Scaffold for histone acetyltransferase complexes, epigenetic regulation

Studied in transcriptional control and histone modification

Xxylt1

|

Xyloside xylosyltransferase 1

Synonyms:

Xyxlt, XylT-Like

Gene ID (NCBI):

268880

Involved in glycosylation of Notch EGF repeats

Model for Notch pathway and glycosylation defects

Zkscan17

|

Zinc finger with KRAB and SCAN domains 17

Synonyms:

Zfp37l

Gene ID (NCBI):

268417

Transcription factor; contains KRAB and SCAN domains

Candidate for transcription and gene regulation studies

Zbtb24

|

Zinc finger and BTB domain containing 24

Synonyms:

Cxxc13

Gene ID (NCBI):

268294

Transcriptional regulator involved in epigenetic control and DNA methylation

Model for immunodeficiency and epigenetic regulation

Acmsd

|

Aminocarboxymuconate semialdehyde decarboxylase

Synonyms:

ACMS decarboxylase

Gene ID (NCBI):

266645

Enzyme in tryptophan-kynurenine pathway; diverts NAD+ biosynthesis

Model for NAD+ metabolism and neurobiology

Ropn1l

|

Rhophilin associated tail protein 1-like

Synonyms:

Ropporin-1-like

Gene ID (NCBI):

252967

Sperm tail-associated protein; implicated in motility and structural integrity

Studied in sperm motility and reproductive biology

Il27

|

Interleukin 27

Synonyms:

IL-27, IL27p28

Gene ID (NCBI):

246779

Cytokine involved in regulation of T-helper cell responses

Model for immune regulation and cytokine therapy

Rhbdl3

|

Rhomboid-like 3 (inactive)

Synonyms:

Rhbdd2

Gene ID (NCBI):

246104

Inactive rhomboid protease homolog; function not well defined

Investigated in intramembrane signaling and cancer

Mpst

|

Mercaptopyruvate sulfurtransferase

Synonyms:

Tst2, Mst

Gene ID (NCBI):

246221

Catalyzes sulfur transfer; involved in cysteine metabolism and H₂S biosynthesis

Studied in oxidative stress, H₂S signaling, and sulfur metabolism

Kcne2

|

Potassium voltage-gated channel subfamily E member 2

Synonyms:

MinK-related peptide 1 (MiRP1)

Gene ID (NCBI):

246133

Modulates various potassium channels including KCNQ1

Model for cardiac electrophysiology and gastric secretion

Rbm47

|

RNA binding motif protein 47

Synonyms:

—

Gene ID (NCBI):

245945

Involved in RNA editing and post-transcriptional regulation

Studied in RNA regulation and tumor biology

Mrap2

|

Melanocortin 2 receptor accessory protein 2

Synonyms:

—

Gene ID (NCBI):

244958

Regulates melanocortin receptor trafficking and signaling

Studied in energy balance, obesity, and neuroendocrine signaling

Npat

|

Nuclear protein, ataxia-telangiectasia locus

Synonyms:

—

Gene ID (NCBI):

244879

Involved in cell cycle regulation; phosphorylated by ATM kinase

Studied in DNA damage response and cell cycle control

Kdm4d

|

Lysine demethylase 4D

Synonyms:

Jmjd2d

Gene ID (NCBI):

244694

Demethylates H3K9me2/3; involved in chromatin remodeling and transcription

Studied in epigenetics, inflammation, and cancer biology

Rpgrip1l

|

RPGRIP1-like

Synonyms:

Ftm, NPHP8

Gene ID (NCBI):

244585

Ciliary protein involved in basal body and transition zone structure

Model for ciliopathies and brain development

Elmod2

|

ELMO domain containing 2

Synonyms:

—

Gene ID (NCBI):

244548

Acts as GTPase-activating protein (GAP) for ARF family GTPases

Studied in mitochondrial dynamics and innate immunity

Erlin2

|

ER lipid raft associated 2

Synonyms:

SPFH2

Gene ID (NCBI):

244373

Part of ER membrane complex; involved in ERAD and lipid homeostasis

Used in neurodegeneration and ER stress studies

Mcph1

|

Microcephalin 1

Synonyms:

BRIT1

Gene ID (NCBI):

244329

Involved in DNA damage response and chromosome condensation

Model for microcephaly and DNA repair defects

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(Anaveon) ANV600 is a potent, cis-signaling, IL-2Rβ/γ directed IL-2 which efficiently expands intratumoral stem-like CD8 T cells

PD-1 & strong tumor growth inhibition

(Maxivax) Sustained delivery of low-dose anti-CTLA-4 by genetically engineered encapsulated cells drives tumor response and prolongs survival in a colorectal cancer model

CTLA-4 & survival in a colorectal cancer model

(Arcus) AB598, a Therapeutic Anti-Human CD39 Antibody, Binds and Inhibits CD39 Enzymatic Activity In Vivo to Promote Anti-Tumor Immunity

Anti hCD39 to promote anti-tumor immunity

CD3 humanized mouse models as validated tools to assess immune-related adverse events of T-cell engagers

CD3 and BRGSF-HIS to assess IrAEs

Anti-VISTA agents profiling: complementarity of BRGSF-HIS and hVISTA Knock-in as preclinical models for immunotherapies

BRGSF-HIS & hVISTA for immunotherapies

(Sensei) SNS-101, a monoclonal antibody that is highly selective for VISTA in the tumor microenvironment, demonstrates favorable pharmacokinetic and cytokine release characteristics and potentiates anti-PD-1 responsiveness

VISTA in the tumor microenvironment

Apr 2022

(Curadev) Intravenous administration of the small molecule STING agonist CRD5500 elicits potent anti-tumor immune responses in cold tumors

hSTING & anti-tumor response in cold tumors

Apr 2022

Translatable preclinical mouse models for assessment of T-cell engager-induced CRS

BRGSF-HIS & CD3ε in CRS

Apr 2022

(Kineta) A Fully Human anti-VISTA Antibody as a Promising Therapy Against Poorly Immunogenic Tumors

anti-hVISTA against poorly immunogenic tumors

(Charles River) Enhanced anti-tumor lymphocyte function and frequencies measured by multichromatic flow cytometry in human CTLA-4 knock-in mice in a colorectal carcinoma model after treatment with ipilimumab

hCTLA-4 mice as a colorectal carcinoma model

Apr 2020

(Charles River) Validation of humanized PD-1 knock-in mice as an emerging model to evaluate human specific PD-1 therapeutics

hPD-1 mice as a model to evaluate human specific PD-1 therapeutics

Mar 2019

No results

 Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid‑Driven T‑Cell Activation

Cancer Immunol Res

Sep 2025

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

J Immunother Cancer

Aug 2025

Advancing In Vivo Detection of T‑Cell Function: Development and Preclinical Evaluation of ⁸⁹Zr‑Ivuxolimab, a Human OX40 PET Tracer

J Nucl Med

Jul 2025

Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies

Microbiol Spectr

Jul 2025

ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy

J Immunother Cancer

Jul 2025

PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

Sci Adv

Jun 2025

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Cancer Immunol Res

May 2025

A Novel B7-H4xCD3 Bispecific T Cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune-Checkpoint Therapies

Mol Cancer Ther

May 2025

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Nat Commun

May 2025

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model

J Clin Invest

Mar 2025

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice

Alzheimers Res Ther

Jan 2025

NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control

Cancer Immunol Res

Jan 2025

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Theranostics

Aug 2024

Highlighted article

Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993

Eur J Nucl Med Mol Imaging

Jul 2024

Highlighted article

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

JCI Insight

May 2024

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight

May 2024

HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors

Mol Cancer Ther

Highlighted article

CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Clin Cancer Res

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

Highlighted article

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas

Hum Mol Genet

Mar 2024

Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Front Immunol

Feb 2024

Highlighted article

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

Feb 2024

Highlighted article

Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9

Hear Res

Dec 2023

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Front Immunol

Dec 2023

Highlighted article

Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

Cell Mol Life Sci

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Front Immunol

Oct 2023

Highlighted article

Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

Sep 2023

Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment

Proc Natl Acad Sci U S A

Jun 2023

SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties

Immunohorizons

Jun 2023

CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

PLoS One

Highlighted article

A gain-of-function filamin A mutation in mouse platelets induces thrombus instability

J Thromb Haemost

Feb 2023

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Pancreatology

Oct 2022

An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Acta Biomater

Oct 2022

Highlighted article

Hyaluronan Synthase 3 is Protective After Cardiac Ischemia-Reperfusion by preserving the T cell Response

Matrix Biol

Sep 2022

Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells

Front Immunol

Sep 2022

IgG against the membrane-proximal portion of the desmoglein 3 ectodomain induces loss of keratinocyte adhesion, a hallmark in pemphigus vulgaris

J Invest Dermatol

Aug 2022

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells

J Allergy Clin Immunol

Enhanced half-life and antitumor activity of Interleukin-15 through genetic fusion of a serum albumin-specific protein binder

Int J Pharmac

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

J Immunother Cancer

Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Prog Neurobiol

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Nat Commun

An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Nat Cancer

Highlighted article

A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

Cell Rep

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Sci Rep

Feb 2022

Highlighted article

Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia

Mol Cancer

Jan 2022

TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy

Neurobiol Dis

Dec 2021

G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes

ACS Pharmacol Transl Sci

Dec 2021

Novel humanized mesothelin-expressing genetically engineered mouse models underscore challenges in delivery of complex therapeutics to pancreatic cancers

Mol Cancer Ther

Oct 2021

Cardiac investigations in sudden unexpected death in DEPDC5-related epilepsy

Ann Neurol

Oct 2021

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Cell Death Dis

Jul 2021

Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

Nat Med

Jul 2021

Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.

Matrix Biol

May 2021

Albumin protects the liver from tumor necrosis factor α-induced immunopathology

FASEB J

May 2021

In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders

Bioconjug Chem

Mar 2021

Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Proc Natl Acad Sci U S A

Mar 2021

Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells

Cancer Discov

Dec 2020

Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo

J Bone Miner Res

Apr 2020

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Nat Chem Biol

Mar 2020

VISTA is an acidic pH-selective ligand for PSGL-1

Nature

Mar 2020

Highlighted article

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

Science

Dec 2019

Highlighted article

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Cell

Jul 2019

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Nat Chem Biol

Apr 2019

The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

J Immunother Cancer

Mar 2019

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

Sci Adv

Feb 2019

Molybdenum cofactor deficiency type B knock-in mouse models carrying patient-identical mutations and their rescue by singular AAV injections

Hum Genet

Jan 2019

Humanization of the Blood–Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus — Lessons from Three Unsuccessful Approaches

Eur J Microbiol Immunol

Oct 2018

Histological and behavioural phenotypes of a novel mutated APP knock-in mouse

J Alzheimers Dis

Jul 2018

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Cell Physiol Biochem

Jul 2018

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

Invest Ophthalmol Vis Sci

Dec 2017

An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes

JCI Insight

Nov 2017

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.

PLoS One

Oct 2017

Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression

Matrix Biol

Sep 2017

Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen.

EMBO J

May 2017

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop.

Circ Res

Oct 2016

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

Brain

Jun 2016

C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.

PLoS One

Apr 2016

An antibody biosensor establishes the activation of the M1 muscarinic acetylcholine receptor during learning and memory

J Biol Chem

Mar 2016

Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.

J Am Heart Assoc

Dec 2015

Generation of a double transgenic humanised neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs

J Control Release

Dec 2015

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Arterioscler Thromb Vasc Biol

Nov 2015

In vivo structure‐function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL‐deficient (hl−/−) mice

Physiol Rep

Apr 2015

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

Blood

Feb 2015

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

J Bone Miner Res

Jan 2015

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

J Neurosci

Nov 2014

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

Cell Death Differ

Feb 2014

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

Cell Mol Life Sci

Jul 2013

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model

Blood

Apr 2013

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Diabetes

Sep 2012

Abnormal Cognition Sleep EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse PLB1.

PLoS One

Nov 2011

Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

J Pharmacol Exp Ther

Oct 2011

A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies

Humanized ICP in immuno-oncology

Part 1: Toward a better effective preclinical model in immuno-oncology

Oct 2019

Immuno-oncolology models

A VISTA on naive T cell fate

Jan 2020

Humanized ICP mouse

Part 4: Humanized immune checkpoint mouse models for immuno-oncology studies

Feb 2020

Immuno-oncolology models

15 min read

May 2020

HSA/hFcRn, a powerful model for your PK/PD studies

Immuno-oncolology models

6 min read

Jul 2020

Define “humanized”: two mouse models helping produce cancer immunotherapies

Humanized mouse models

4 min read

Nov 2020

A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers

T-cell engager

Uncoupling toxicity from therapeutic efficacy: the new challenge of immunotherapies

Feb 2021

Assess toxicity with ICP

Uncoupling toxicity from therapeutic efficacy: a case study on ATOR-1015

Bispecific antibodies

Uncoupling efficacy from toxicity: a case study on MEDI5752

Bispecific antibodies

The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R

Physiological relevancy in preclinical models

4 min read

Sep 2021

Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies

Therapeutic efficacy and pharmacokinetics

Relevant preclinical models to test T-cell engagers: The case of CD28

Jan 2022

T-cell engager

An alternative approach to immunotherapy: A bispecific agonist

Humanized PD-1 & GITR mouse

4 min read

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

T-cell engager CD3

Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help

Assess T-cell engager in BRGSF-HIS

6 min read

Jun 2022

A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway

Humanized PD-1/PD-L1 mouse and cell line

An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Humanized HSA/hFcRn mouse

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Humanized ICP mouse and cell lines

9 min read

Jun 2023

Assessing T-cell engagers efficacy in vivo: Versatility of BRGSF-HIS mice

Assess T-cell engager in BRGSF-HIS

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Oct 2023

Humanized VISTA mouse & Pharmacokinetics

An engineered humanized common light chain mouse model to develop bispecific antibodies

Dec 2023

Humanized cLC model - Bispecific antibody development

Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized genO-hCD47/hSIRPα mouse and genO-MC38-hPD-L1-hCD47-LZ cell line

Feb 2024

Targeting the human CD47/SIRPα axis

BRGSF-HIS: genOway’s mouse model to evaluate the pathogenesis of Staphylococcus aureus Panton-Valentine leukocidin in acute implant-associated osteomyelitis

Mar 2024

BRGSF-HIS as model for acute implant-associated osteomyelitis

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

VISTA - safety and PK profiling

HPN328, a new T cell–activating construct for treating solid tumors

CD3ε - T-cell engager assessment

7 min read

Jul 2024

Development of a new antibody-drug conjugate against CD71, INA03, for the treatment of leukemia

TFRC for anti-cancer therapies

New CD4-specific minibodies to predict cancer treatment outcomes

Jul 2024

CD4 for cancer treatment outcomes

A radiolabeled VISTA antibody for imaging VISTA expression

Oct 2024

hVISTA - antibodies & PET imaging

7 min read

Oct 2024

Targeted immunotherapy against autoreactive B cells in autoimmune diseases

T-cell engagers in immunotherapies